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The immune response and immune evasion characteristics in SARS-CoV, MERS-CoV, and SARS-CoV-2: Vaccine design strategies.
Int Immunopharmacol. 2021 Mar; 92:107051.II

Abstract

The worldwide outbreak of SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 as a novel human coronavirus, was the worrying news at the beginning of 2020. Since its emergence complicated more than 870,000 individuals and led to more than 43,000 deaths worldwide. Considering to the potential threat of a pandemic and transmission severity of it, there is an urgent need to evaluate and realize this new virus's structure and behavior and the immunopathology of this disease to find potential therapeutic protocols and to design and develop effective vaccines. This disease is able to agitate the response of the immune system in the infected patients, so ARDS, as a common consequence of immunopathological events for infections with Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV, and SARS-CoV-2, could be the main reason for death. Here, we summarized the immune response and immune evasion characteristics in SARS-CoV, MERS-CoV, and SARS-CoV-2 and therapeutic and prophylactic strategies with a focus on vaccine development and its challenges.

Authors+Show Affiliations

Deputy of Research & Technology, Ardabil University of Medical Sciences, Ardabil, Iran; Pharmaceutical Sciences Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.Pharmaceutical Sciences Research Center, Ardabil University of Medical Sciences, Ardabil, Iran; Department of Pharmacology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran.Deputy of Research & Technology, Ardabil University of Medical Sciences, Ardabil, Iran.Department of Microbiology, Parasitology, and Immunology, Ardabil University of Medical Sciences, Ardabil, Iran.Department of Microbiology, Parasitology, and Immunology, Ardabil University of Medical Sciences, Ardabil, Iran. Electronic address: E.safarzadeh@arums.ac.ir.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33429331

Citation

Molaei, Soheila, et al. "The Immune Response and Immune Evasion Characteristics in SARS-CoV, MERS-CoV, and SARS-CoV-2: Vaccine Design Strategies." International Immunopharmacology, vol. 92, 2021, p. 107051.
Molaei S, Dadkhah M, Asghariazar V, et al. The immune response and immune evasion characteristics in SARS-CoV, MERS-CoV, and SARS-CoV-2: Vaccine design strategies. Int Immunopharmacol. 2021;92:107051.
Molaei, S., Dadkhah, M., Asghariazar, V., Karami, C., & Safarzadeh, E. (2021). The immune response and immune evasion characteristics in SARS-CoV, MERS-CoV, and SARS-CoV-2: Vaccine design strategies. International Immunopharmacology, 92, 107051. https://doi.org/10.1016/j.intimp.2020.107051
Molaei S, et al. The Immune Response and Immune Evasion Characteristics in SARS-CoV, MERS-CoV, and SARS-CoV-2: Vaccine Design Strategies. Int Immunopharmacol. 2021;92:107051. PubMed PMID: 33429331.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The immune response and immune evasion characteristics in SARS-CoV, MERS-CoV, and SARS-CoV-2: Vaccine design strategies. AU - Molaei,Soheila, AU - Dadkhah,Masoomeh, AU - Asghariazar,Vahid, AU - Karami,Chiman, AU - Safarzadeh,Elham, Y1 - 2020/09/29/ PY - 2020/07/04/received PY - 2020/09/24/revised PY - 2020/09/24/accepted PY - 2021/1/12/pubmed PY - 2021/2/23/medline PY - 2021/1/11/entrez KW - Immune response KW - SARS-CoV-2 KW - Vaccine SP - 107051 EP - 107051 JF - International immunopharmacology JO - Int Immunopharmacol VL - 92 N2 - The worldwide outbreak of SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 as a novel human coronavirus, was the worrying news at the beginning of 2020. Since its emergence complicated more than 870,000 individuals and led to more than 43,000 deaths worldwide. Considering to the potential threat of a pandemic and transmission severity of it, there is an urgent need to evaluate and realize this new virus's structure and behavior and the immunopathology of this disease to find potential therapeutic protocols and to design and develop effective vaccines. This disease is able to agitate the response of the immune system in the infected patients, so ARDS, as a common consequence of immunopathological events for infections with Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV, and SARS-CoV-2, could be the main reason for death. Here, we summarized the immune response and immune evasion characteristics in SARS-CoV, MERS-CoV, and SARS-CoV-2 and therapeutic and prophylactic strategies with a focus on vaccine development and its challenges. SN - 1878-1705 UR - https://www.unboundmedicine.com/medline/citation/33429331/The_immune_response_and_immune_evasion_characteristics_in_SARS_CoV_MERS_CoV_and_SARS_CoV_2:_Vaccine_design_strategies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5769(20)32205-0 DB - PRIME DP - Unbound Medicine ER -