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The association of photo-induced collagen degeneration and the development of telangiectasias in rosacea.
J Anat. 2021 06; 238(6):1355-1358.JA

Abstract

Rosacea is a chronic, often progressive disorder characterized by facial erythema, telangiectasias, papules, pustules, and/or rhinophyma. In this study, we investigated the tissue structure in rosacea compared to controls. We performed a case-control study between five patients with mild-to-moderate erythematotelangiectatic rosacea (ETR) and five matched controls. Facial biopsy samples from rosacea patients and controls were stained with picrosirius red for collagen and CD31 for microvessel identification. Mean collagen content was significantly greater in control samples (19.603% ±8.821%) compared to rosacea samples (16.812% ± 7.787%, p = 0.030). In contrast, mean microvessel density was significantly higher in rosacea patients (4.775 E-5 ± 1.493 E-5 µm-3) compared to controls (2.559 E-5 ± 8.732 E-6 µm-3 , p = 0.004). Mean microvessel lumen area was also significantly higher in rosacea patients (491.710 ± 610.188 µm2) compared to controls (347.879 ± 539.624 µm2 , p = 0.003). We identified a correlation between decreased collagen content and increased microvessel size and density in rosacea patients that was not observed in controls. These structural changes to the dermal matrix may contribute to the characteristic vessel growth and dilation in rosacea.

Authors+Show Affiliations

Department of Dermatology, Johns Hopkins University, Baltimore, MD, USA.Department of Dermatology, Johns Hopkins University, Baltimore, MD, USA. Department of Dermatology, Medical University of Graz, Graz, Austria.Department of Dermatology, Johns Hopkins University, Baltimore, MD, USA.Department of Dermatology, Johns Hopkins University, Baltimore, MD, USA.Department of Dermatology, Johns Hopkins University, Baltimore, MD, USA.Department of Dermatology, Johns Hopkins University, Baltimore, MD, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33432575

Citation

Thompson, Katherine G., et al. "The Association of Photo-induced Collagen Degeneration and the Development of Telangiectasias in Rosacea." Journal of Anatomy, vol. 238, no. 6, 2021, pp. 1355-1358.
Thompson KG, Rainer BM, Leung S, et al. The association of photo-induced collagen degeneration and the development of telangiectasias in rosacea. J Anat. 2021;238(6):1355-1358.
Thompson, K. G., Rainer, B. M., Leung, S., Qi, J., Kang, S., & Chien, A. L. (2021). The association of photo-induced collagen degeneration and the development of telangiectasias in rosacea. Journal of Anatomy, 238(6), 1355-1358. https://doi.org/10.1111/joa.13394
Thompson KG, et al. The Association of Photo-induced Collagen Degeneration and the Development of Telangiectasias in Rosacea. J Anat. 2021;238(6):1355-1358. PubMed PMID: 33432575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association of photo-induced collagen degeneration and the development of telangiectasias in rosacea. AU - Thompson,Katherine G, AU - Rainer,Barbara M, AU - Leung,Sherry, AU - Qi,Ji, AU - Kang,Sewon, AU - Chien,Anna L, Y1 - 2021/01/11/ PY - 2020/12/05/revised PY - 2020/09/18/received PY - 2020/12/17/accepted PY - 2023/06/01/pmc-release PY - 2021/1/13/pubmed PY - 2021/9/10/medline PY - 2021/1/12/entrez KW - collagen KW - photoaging KW - rosacea KW - telangiectasia KW - telangiectatic photoaging SP - 1355 EP - 1358 JF - Journal of anatomy JO - J Anat VL - 238 IS - 6 N2 - Rosacea is a chronic, often progressive disorder characterized by facial erythema, telangiectasias, papules, pustules, and/or rhinophyma. In this study, we investigated the tissue structure in rosacea compared to controls. We performed a case-control study between five patients with mild-to-moderate erythematotelangiectatic rosacea (ETR) and five matched controls. Facial biopsy samples from rosacea patients and controls were stained with picrosirius red for collagen and CD31 for microvessel identification. Mean collagen content was significantly greater in control samples (19.603% ±8.821%) compared to rosacea samples (16.812% ± 7.787%, p = 0.030). In contrast, mean microvessel density was significantly higher in rosacea patients (4.775 E-5 ± 1.493 E-5 µm-3) compared to controls (2.559 E-5 ± 8.732 E-6 µm-3 , p = 0.004). Mean microvessel lumen area was also significantly higher in rosacea patients (491.710 ± 610.188 µm2) compared to controls (347.879 ± 539.624 µm2 , p = 0.003). We identified a correlation between decreased collagen content and increased microvessel size and density in rosacea patients that was not observed in controls. These structural changes to the dermal matrix may contribute to the characteristic vessel growth and dilation in rosacea. SN - 1469-7580 UR - https://www.unboundmedicine.com/medline/citation/33432575/The_association_of_photo_induced_collagen_degeneration_and_the_development_of_telangiectasias_in_rosacea_ DB - PRIME DP - Unbound Medicine ER -