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Can curcumin supplementation reduce plasma levels of gut-derived uremic toxins in hemodialysis patients? A pilot randomized, double-blind, controlled study.
Int Urol Nephrol. 2021 Jun; 53(6):1231-1238.IU

Abstract

BACKGROUND

Gut dysbiosis is common in patients with chronic kidney disease (CKD) and is closely related to inflammatory processes. Some nutritional strategies, such as bioactive compounds present in curcumin, have been proposed as an option to modulate the gut microbiota and decrease the production of uremic toxins such as indoxyl sulfate (IS), p-cresyl sulfate (pCS) and indole-3 acetic acid (IAA).

OBJECTIVE

To evaluate the effects of curcumin supplementation on uremic toxins plasma levels produced by gut microbiota in patients with CKD on hemodialysis (HD).

METHODS

Randomized, double-blind trial in 28 patients [53.6 ± 13.4 years, fourteen men, BMI 26.7 ± 3.7 kg/m2, dialysis vintage 37.5 (12-193) months]. Fourteen patients were randomly allocated to the curcumin group and received 100 mL of orange juice with 12 g carrot and 2.5 g of turmeric and 14 patients to the control group who received the same juice but without turmeric three times per week after HD sessions for three months. IS, pCS, IAA plasma levels were measured by reverse-phase high-performance liquid chromatography RESULTS: After three months of supplementation, the curcumin group showed a significant decrease in pCS plasma levels [from 32.4 (22.1-45.9) to 25.2 (17.9-37.9) mg/L, p = 0.009], which did not occur in the control group. No statistical difference was observed in IS and IAA levels in both groups.

CONCLUSION

The oral supplementation of curcumin for three months seems to reduce p-CS plasma levels in HD patients, suggesting a gut microbiota modulation.

Authors+Show Affiliations

Graduate Program in Nutrition Sciences, Federal Fluminense University (UFF), Niterói, RJ, Brazil.Graduate Program in Medical Sciences, Federal Fluminense University (UFF), Niterói, RJ, Brazil.Graduate Program in Cardiovascular Sciences, Federal Fluminense University (UFF), Niterói, RJ, Brazil.Graduate Program in Medical Sciences, Federal Fluminense University (UFF), Niterói, RJ, Brazil.Graduate Program in Medical Sciences, Federal Fluminense University (UFF), Niterói, RJ, Brazil.Department of Basic Pathology, Federal University of Parana (UFPR), Curitiba, Brazil.Department of Basic Pathology, Federal University of Parana (UFPR), Curitiba, Brazil.Department of Basic Pathology, Federal University of Parana (UFPR), Curitiba, Brazil.Department of Nephrology, Hospital Lyon Sud, INSERM 1060, Université Claude Bernard, 69495, Lyon, France.Graduate Program in Nutrition Sciences, Federal Fluminense University (UFF), Niterói, RJ, Brazil. dmafra30@gmail.com. Graduate Program in Medical Sciences, Federal Fluminense University (UFF), Niterói, RJ, Brazil. dmafra30@gmail.com. Graduate Program in Cardiovascular Sciences, Federal Fluminense University (UFF), Niterói, RJ, Brazil. dmafra30@gmail.com. Unidade de Pesquisa Clínica, Rua Marques do Paraná, 303, Niterói, RJ, 24033-900, Brazil. dmafra30@gmail.com.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

33438085

Citation

Salarolli, Roberta T., et al. "Can Curcumin Supplementation Reduce Plasma Levels of Gut-derived Uremic Toxins in Hemodialysis Patients? a Pilot Randomized, Double-blind, Controlled Study." International Urology and Nephrology, vol. 53, no. 6, 2021, pp. 1231-1238.
Salarolli RT, Alvarenga L, Cardozo LFMF, et al. Can curcumin supplementation reduce plasma levels of gut-derived uremic toxins in hemodialysis patients? A pilot randomized, double-blind, controlled study. Int Urol Nephrol. 2021;53(6):1231-1238.
Salarolli, R. T., Alvarenga, L., Cardozo, L. F. M. F., Teixeira, K. T. R., de S G Moreira, L., Lima, J. D., Rodrigues, S. D., Nakao, L. S., Fouque, D., & Mafra, D. (2021). Can curcumin supplementation reduce plasma levels of gut-derived uremic toxins in hemodialysis patients? A pilot randomized, double-blind, controlled study. International Urology and Nephrology, 53(6), 1231-1238. https://doi.org/10.1007/s11255-020-02760-z
Salarolli RT, et al. Can Curcumin Supplementation Reduce Plasma Levels of Gut-derived Uremic Toxins in Hemodialysis Patients? a Pilot Randomized, Double-blind, Controlled Study. Int Urol Nephrol. 2021;53(6):1231-1238. PubMed PMID: 33438085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can curcumin supplementation reduce plasma levels of gut-derived uremic toxins in hemodialysis patients? A pilot randomized, double-blind, controlled study. AU - Salarolli,Roberta T, AU - Alvarenga,Livia, AU - Cardozo,Ludmila F M F, AU - Teixeira,Karla T R, AU - de S G Moreira,Laís, AU - Lima,Jordana D, AU - Rodrigues,Silvia D, AU - Nakao,Lia S, AU - Fouque,Denis, AU - Mafra,Denise, Y1 - 2021/01/12/ PY - 2020/09/10/received PY - 2020/12/15/accepted PY - 2021/1/14/pubmed PY - 2021/10/7/medline PY - 2021/1/13/entrez KW - Chronic kidney disease KW - Curcumin KW - Gut microbiota KW - Hemodialysis KW - Uremic toxins SP - 1231 EP - 1238 JF - International urology and nephrology JO - Int Urol Nephrol VL - 53 IS - 6 N2 - BACKGROUND: Gut dysbiosis is common in patients with chronic kidney disease (CKD) and is closely related to inflammatory processes. Some nutritional strategies, such as bioactive compounds present in curcumin, have been proposed as an option to modulate the gut microbiota and decrease the production of uremic toxins such as indoxyl sulfate (IS), p-cresyl sulfate (pCS) and indole-3 acetic acid (IAA). OBJECTIVE: To evaluate the effects of curcumin supplementation on uremic toxins plasma levels produced by gut microbiota in patients with CKD on hemodialysis (HD). METHODS: Randomized, double-blind trial in 28 patients [53.6 ± 13.4 years, fourteen men, BMI 26.7 ± 3.7 kg/m2, dialysis vintage 37.5 (12-193) months]. Fourteen patients were randomly allocated to the curcumin group and received 100 mL of orange juice with 12 g carrot and 2.5 g of turmeric and 14 patients to the control group who received the same juice but without turmeric three times per week after HD sessions for three months. IS, pCS, IAA plasma levels were measured by reverse-phase high-performance liquid chromatography RESULTS: After three months of supplementation, the curcumin group showed a significant decrease in pCS plasma levels [from 32.4 (22.1-45.9) to 25.2 (17.9-37.9) mg/L, p = 0.009], which did not occur in the control group. No statistical difference was observed in IS and IAA levels in both groups. CONCLUSION: The oral supplementation of curcumin for three months seems to reduce p-CS plasma levels in HD patients, suggesting a gut microbiota modulation. SN - 1573-2584 UR - https://www.unboundmedicine.com/medline/citation/33438085/Can_curcumin_supplementation_reduce_plasma_levels_of_gut_derived_uremic_toxins_in_hemodialysis_patients_A_pilot_randomized_double_blind_controlled_study_ DB - PRIME DP - Unbound Medicine ER -