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Voltage-Switchable Biosensor with Gold Nanoparticles on TiO2 Nanotubes Decorated with CdS Quantum Dots for the Detection of Cholesterol and H2O2.
ACS Appl Mater Interfaces. 2021 Jan 27; 13(3):3653-3668.AA

Abstract

A thin layer of gold nanoparticles (Au NPs) sputtered on cadmium sulfide quantum dots (CdS QDs) decorated anodic titanium dioxide nanotubes (TNTs) (Au/CdS QDs/TNTs) was fabricated and explored for the nonenzymatic detection of cholesterol and hydrogen peroxide (H2O2). Morphological studies of the sensor revealed the formation of uniform nanotubes decorated with a homogeneously dispersed CdS QDs and Au NPs layer. The electrochemical measurements showed an enhanced electrocatalytic performance with a fast electron transfer (∼2 s) between the redox centers of each analyte and electrode surface. The hybrid nanostructure (Au/CdS QDs/TNTs) electrode exhibited about a 6-fold increase in sensitivity for both cholesterol (10,790 μA mM-1 cm-2) and H2O2 (78,833 μA mM-1 cm-2) in analyses compared to the pristine samples. The hybrid electrode utilized different operational potentials for both analytes, which may lead to a voltage-switchable dual-analyte biosensor with a higher selectivity. The biosensor also demonstrated a good reproducibility, thermal stability, and increased shelf life. In addition, the clinical significance of the biosensor was tested for cholesterol and H2O2 in real blood samples, which showed maximum relative standard deviations of 1.8 and 2.3%, respectively. These results indicate that a Au/CdS QDs/TNTs-based hybrid nanostructure is a promising choice for an enzyme-free biosensor due to its suitable band gap alignment and higher electrocatalytic activities.

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Authors+Show Affiliations

Department of Physics and Applied Mathematics, Pakistan Institute of Engineering and Applied Sciences (PIEAS), Islamabad 45650, Pakistan.

Department of Physics and Applied Mathematics, Pakistan Institute of Engineering and Applied Sciences (PIEAS), Islamabad 45650, Pakistan.

Nanomaterials Research Group (NRG), Physics Division, PINSTECH, Islamabad 44000, Pakistan.

Department of Clinical & Diagnostic Sciences, the University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.

Nanomaterials Research Group (NRG), Physics Division, PINSTECH, Islamabad 44000, Pakistan.

Nanomaterials Research Group (NRG), Physics Division, PINSTECH, Islamabad 44000, Pakistan.

Nanomaterials Research Group (NRG), Physics Division, PINSTECH, Islamabad 44000, Pakistan.

Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Martensstrasse 7, D-91058 Erlangen, Germany. Department of Chemistry, King Abdulaziz University, Jeddah 21413, Saudi Arabia.

Department of Nuclear and Quantum Engineering (NQe), KAIST, Daejeon 34141, South Korea.

Nanomaterials Research Group (NRG), Physics Division, PINSTECH, Islamabad 44000, Pakistan.

MeSH

Biosensing TechniquesCadmium CompoundsCholesterolElectrochemical TechniquesGoldHumansHydrogen PeroxideLimit of DetectionMetal NanoparticlesNanotubesQuantum DotsSulfidesTitanium

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33439005

Citation

Khaliq, Nilem, et al. "Voltage-Switchable Biosensor With Gold Nanoparticles On TiO2 Nanotubes Decorated With CdS Quantum Dots for the Detection of Cholesterol and H2O2." ACS Applied Materials & Interfaces, vol. 13, no. 3, 2021, pp. 3653-3668.

Khaliq N, Rasheed MA, Khan M, et al. Voltage-Switchable Biosensor with Gold Nanoparticles on TiO2 Nanotubes Decorated with CdS Quantum Dots for the Detection of Cholesterol and H2O2. ACS Appl Mater Interfaces. 2021;13(3):3653-3668.

Khaliq, N., Rasheed, M. A., Khan, M., Maqbool, M., Ahmad, M., Karim, S., Nisar, A., Schmuki, P., Cho, S. O., & Ali, G. (2021). Voltage-Switchable Biosensor with Gold Nanoparticles on TiO2 Nanotubes Decorated with CdS Quantum Dots for the Detection of Cholesterol and H2O2. ACS Applied Materials & Interfaces, 13(3), 3653-3668. https://doi.org/10.1021/acsami.0c19979

Khaliq N, et al. Voltage-Switchable Biosensor With Gold Nanoparticles On TiO2 Nanotubes Decorated With CdS Quantum Dots for the Detection of Cholesterol and H2O2. ACS Appl Mater Interfaces. 2021 Jan 27;13(3):3653-3668. PubMed PMID: 33439005.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Voltage-Switchable Biosensor with Gold Nanoparticles on TiO2 Nanotubes Decorated with CdS Quantum Dots for the Detection of Cholesterol and H2O2. AU - Khaliq,Nilem, AU - Rasheed,Muhammad Asim, AU - Khan,Maaz, AU - Maqbool,Muhammad, AU - Ahmad,Mashkoor, AU - Karim,Shafqat, AU - Nisar,Amjad, AU - Schmuki,Patrik, AU - Cho,Sung Oh, AU - Ali,Ghafar, Y1 - 2021/01/13/ PY - 2021/1/14/pubmed PY - 2021/3/3/medline PY - 2021/1/13/entrez KW - amperometry KW - anodization KW - biosensor KW - cadmium sulfide quantum dots KW - gold nanoparticles KW - titanium oxide nanotubes SP - 3653 EP - 3668 JF - ACS applied materials & interfaces JO - ACS Appl Mater Interfaces VL - 13 IS - 3 N2 - A thin layer of gold nanoparticles (Au NPs) sputtered on cadmium sulfide quantum dots (CdS QDs) decorated anodic titanium dioxide nanotubes (TNTs) (Au/CdS QDs/TNTs) was fabricated and explored for the nonenzymatic detection of cholesterol and hydrogen peroxide (H2O2). Morphological studies of the sensor revealed the formation of uniform nanotubes decorated with a homogeneously dispersed CdS QDs and Au NPs layer. The electrochemical measurements showed an enhanced electrocatalytic performance with a fast electron transfer (∼2 s) between the redox centers of each analyte and electrode surface. The hybrid nanostructure (Au/CdS QDs/TNTs) electrode exhibited about a 6-fold increase in sensitivity for both cholesterol (10,790 μA mM-1 cm-2) and H2O2 (78,833 μA mM-1 cm-2) in analyses compared to the pristine samples. The hybrid electrode utilized different operational potentials for both analytes, which may lead to a voltage-switchable dual-analyte biosensor with a higher selectivity. The biosensor also demonstrated a good reproducibility, thermal stability, and increased shelf life. In addition, the clinical significance of the biosensor was tested for cholesterol and H2O2 in real blood samples, which showed maximum relative standard deviations of 1.8 and 2.3%, respectively. These results indicate that a Au/CdS QDs/TNTs-based hybrid nanostructure is a promising choice for an enzyme-free biosensor due to its suitable band gap alignment and higher electrocatalytic activities. SN - 1944-8252 UR - https://www.unboundmedicine.com/medline/citation/33439005/Voltage_Switchable_Biosensor_with_Gold_Nanoparticles_on_TiO2_Nanotubes_Decorated_with_CdS_Quantum_Dots_for_the_Detection_of_Cholesterol_and_H2O2_ DB - PRIME DP - Unbound Medicine ER -