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Gold digging: Searching for gut microbiota that enhances antitumor immunity.
J Cell Physiol. 2021 08; 236(8):5495-5511.JC

Abstract

Programmed cell death protein-1/programmed cell death-ligand 1 and cytotoxic T-lymphocyte antigen-4 are two immune checkpoint inhibitors (ICIs), exhibiting significant antitumor effects on multiple types of cancers in clinical practice. However, only some patients respond to ICI agents, which limits their widespread application. Recent findings revealed that the gut microbiota is relevant to host health through the modulation of host physical and immune functions. Therefore, the modulation of gut microbiota to achieve the desired taxa may be a potential strategy to improve the efficacy of immunotherapies. In this review, we classified the relative microbes according to their taxonomic information and aimed to clarify their modulatory functions and potent effects on ICI immunotherapy by focusing on recent trials investigating the relationships between the gut microbiota and ICIs.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Hou F
Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Nanfang Hospital, Southern Medical University, Guangzhou, China. State Key Laboratory of Pathogen and Biosecurity, Department of Unknown Microbiology, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Pan Z
State Key Laboratory of Pathogen and Biosecurity, Department of Unknown Microbiology, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Yang R
State Key Laboratory of Pathogen and Biosecurity, Department of Unknown Microbiology, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Zhi F
Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Bi Y
State Key Laboratory of Pathogen and Biosecurity, Department of Unknown Microbiology, Beijing Institute of Microbiology and Epidemiology, Beijing, China.

MeSH

Antineoplastic Agents, ImmunologicalB7-H1 AntigenCTLA-4 AntigenGastrointestinal MicrobiomeHumansImmunotherapyNeoplasms

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

33452716

Citation

Hou, Fengyi, et al. "Gold Digging: Searching for Gut Microbiota That Enhances Antitumor Immunity." Journal of Cellular Physiology, vol. 236, no. 8, 2021, pp. 5495-5511.
Hou F, Pan Z, Yang R, et al. Gold digging: Searching for gut microbiota that enhances antitumor immunity. J Cell Physiol. 2021;236(8):5495-5511.
Hou, F., Pan, Z., Yang, R., Zhi, F., & Bi, Y. (2021). Gold digging: Searching for gut microbiota that enhances antitumor immunity. Journal of Cellular Physiology, 236(8), 5495-5511. https://doi.org/10.1002/jcp.30272
Hou F, et al. Gold Digging: Searching for Gut Microbiota That Enhances Antitumor Immunity. J Cell Physiol. 2021;236(8):5495-5511. PubMed PMID: 33452716.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gold digging: Searching for gut microbiota that enhances antitumor immunity. AU - Hou,Fengyi, AU - Pan,Zhiyuan, AU - Yang,Ruifu, AU - Zhi,Fachao, AU - Bi,Yujing, Y1 - 2021/01/16/ PY - 2020/12/18/revised PY - 2020/09/23/received PY - 2020/12/29/accepted PY - 2021/1/17/pubmed PY - 2021/10/21/medline PY - 2021/1/16/entrez KW - CTLA-4 KW - ICIs KW - PD-1 KW - gut microbiota KW - immunotherapy SP - 5495 EP - 5511 JF - Journal of cellular physiology JO - J Cell Physiol VL - 236 IS - 8 N2 - Programmed cell death protein-1/programmed cell death-ligand 1 and cytotoxic T-lymphocyte antigen-4 are two immune checkpoint inhibitors (ICIs), exhibiting significant antitumor effects on multiple types of cancers in clinical practice. However, only some patients respond to ICI agents, which limits their widespread application. Recent findings revealed that the gut microbiota is relevant to host health through the modulation of host physical and immune functions. Therefore, the modulation of gut microbiota to achieve the desired taxa may be a potential strategy to improve the efficacy of immunotherapies. In this review, we classified the relative microbes according to their taxonomic information and aimed to clarify their modulatory functions and potent effects on ICI immunotherapy by focusing on recent trials investigating the relationships between the gut microbiota and ICIs. SN - 1097-4652 UR - https://www.unboundmedicine.com/medline/citation/33452716/Gold_digging:_Searching_for_gut_microbiota_that_enhances_antitumor_immunity_ DB - PRIME DP - Unbound Medicine ER -