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TEMPS-A (short version) plays a supplementary role in the differential diagnosis between major depressive disorder and bipolar disorder.
Psychiatry Clin Neurosci. 2021 May; 75(5):166-171.PC

Abstract

AIM

Early differential diagnosis between patients with major depressive disorder (MDD) and bipolar disorder (BD), and subsequently providing appropriate treatments are essential. There has been increased interest regarding the association between affective temperaments and mood disorder diagnosis. Our aim was to analyze the diagnostic validity of affective temperaments assessed by the short version of the Temperament Evaluation of Memphis, Pisa, Paris and San Diego-autoquestionnaire version (TEMPS-A), in mood disorder patients.

METHODS

Inpatients with MDD (n = 146) or BD (n = 128) completed the short version of TEMPS-A, and their depressive and manic symptom severities were evaluated. Data of MDD and BD patients were compared by univariable and multivariable analyses.

RESULTS

Of the five affective temperament dimensions, substantially higher hyperthymic, irritable, and cyclothymic temperament scores were found in BD patients than in MDD patients. Using a multivariable logistic regression model built using the severities of depressed and manic conditions, and the five affective temperament subscale scores as independent variables, we identified two factors statistically associated with BD diagnosis (anxious temperament and cyclothymic temperament). The recommended cutoff point for the 12 items evaluating cyclothymic temperament to differentiate BD from MDD was 8 or more 'True' items (sensitivity: 35.9%, specificity: 87.7%).

LIMITATIONS

Our design was cross-sectional, and therefore, there was a possibility of longitudinal diagnostic conversion of patients from MDD to BD.

CONCLUSION

Cyclothymic and anxious temperaments on the short version of TEMPS-A, identified as diagnostic differentiating factors between MDD and BD, may play supplementary roles in the early identification of BD.

Authors+Show Affiliations

Department of Psychiatry, Tokyo Medical University, Tokyo, Japan. Department of Psychiatry, Maezawa Hospital, Ashikaga, Japan.Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Department of Neuropsychiatry, Takikawa Municipal Hospital, Takikawa, Japan.Department of Psychiatry, National Defense Medical College, Tokorozawa, Japan.Department of Psychiatry, Tokyo Medical University, Tokyo, Japan.Department of Psychiatry, Tokyo Medical University, Tokyo, Japan. Department of Psychiatry, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan.Department of Psychiatry, Tokyo Medical University, Tokyo, Japan. Department of Psychiatry, Ibaraki Medical Center, Tokyo Medical University, Ibaraki, Japan.Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.Department of Psychiatry, Tokyo Medical University, Tokyo, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33452845

Citation

Morishita, Chihiro, et al. "TEMPS-A (short Version) Plays a Supplementary Role in the Differential Diagnosis Between Major Depressive Disorder and Bipolar Disorder." Psychiatry and Clinical Neurosciences, vol. 75, no. 5, 2021, pp. 166-171.
Morishita C, Kameyama R, Toda H, et al. TEMPS-A (short version) plays a supplementary role in the differential diagnosis between major depressive disorder and bipolar disorder. Psychiatry Clin Neurosci. 2021;75(5):166-171.
Morishita, C., Kameyama, R., Toda, H., Masuya, J., Fujimura, Y., Higashi, S., Kusumi, I., & Inoue, T. (2021). TEMPS-A (short version) plays a supplementary role in the differential diagnosis between major depressive disorder and bipolar disorder. Psychiatry and Clinical Neurosciences, 75(5), 166-171. https://doi.org/10.1111/pcn.13198
Morishita C, et al. TEMPS-A (short Version) Plays a Supplementary Role in the Differential Diagnosis Between Major Depressive Disorder and Bipolar Disorder. Psychiatry Clin Neurosci. 2021;75(5):166-171. PubMed PMID: 33452845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TEMPS-A (short version) plays a supplementary role in the differential diagnosis between major depressive disorder and bipolar disorder. AU - Morishita,Chihiro, AU - Kameyama,Rie, AU - Toda,Hiroyuki, AU - Masuya,Jiro, AU - Fujimura,Yota, AU - Higashi,Shinji, AU - Kusumi,Ichiro, AU - Inoue,Takeshi, Y1 - 2021/02/05/ PY - 2020/12/12/revised PY - 2020/08/29/received PY - 2021/01/12/accepted PY - 2021/1/17/pubmed PY - 2021/11/9/medline PY - 2021/1/16/entrez KW - TEMPS-A KW - affective disorders KW - affective temperament KW - bipolar disorder KW - major depressive disorder SP - 166 EP - 171 JF - Psychiatry and clinical neurosciences JO - Psychiatry Clin Neurosci VL - 75 IS - 5 N2 - AIM: Early differential diagnosis between patients with major depressive disorder (MDD) and bipolar disorder (BD), and subsequently providing appropriate treatments are essential. There has been increased interest regarding the association between affective temperaments and mood disorder diagnosis. Our aim was to analyze the diagnostic validity of affective temperaments assessed by the short version of the Temperament Evaluation of Memphis, Pisa, Paris and San Diego-autoquestionnaire version (TEMPS-A), in mood disorder patients. METHODS: Inpatients with MDD (n = 146) or BD (n = 128) completed the short version of TEMPS-A, and their depressive and manic symptom severities were evaluated. Data of MDD and BD patients were compared by univariable and multivariable analyses. RESULTS: Of the five affective temperament dimensions, substantially higher hyperthymic, irritable, and cyclothymic temperament scores were found in BD patients than in MDD patients. Using a multivariable logistic regression model built using the severities of depressed and manic conditions, and the five affective temperament subscale scores as independent variables, we identified two factors statistically associated with BD diagnosis (anxious temperament and cyclothymic temperament). The recommended cutoff point for the 12 items evaluating cyclothymic temperament to differentiate BD from MDD was 8 or more 'True' items (sensitivity: 35.9%, specificity: 87.7%). LIMITATIONS: Our design was cross-sectional, and therefore, there was a possibility of longitudinal diagnostic conversion of patients from MDD to BD. CONCLUSION: Cyclothymic and anxious temperaments on the short version of TEMPS-A, identified as diagnostic differentiating factors between MDD and BD, may play supplementary roles in the early identification of BD. SN - 1440-1819 UR - https://www.unboundmedicine.com/medline/citation/33452845/TEMPS_A__short_version__plays_a_supplementary_role_in_the_differential_diagnosis_between_major_depressive_disorder_and_bipolar_disorder_ L2 - https://doi.org/10.1111/pcn.13198 DB - PRIME DP - Unbound Medicine ER -