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Past, present and future role of retinal imaging in neurodegenerative disease.
Prog Retin Eye Res. 2021 Jul; 83:100938.PR

Abstract

Retinal imaging technology is rapidly advancing and can provide ever-increasing amounts of information about the structure, function and molecular composition of retinal tissue in humans in vivo. Most importantly, this information can be obtained rapidly, non-invasively and in many cases using Food and Drug Administration-approved devices that are commercially available. Technologies such as optical coherence tomography have dramatically changed our understanding of retinal disease and in many cases have significantly improved their clinical management. Since the retina is an extension of the brain and shares a common embryological origin with the central nervous system, there has also been intense interest in leveraging the expanding armamentarium of retinal imaging technology to understand, diagnose and monitor neurological diseases. This is particularly appealing because of the high spatial resolution, relatively low-cost and wide availability of retinal imaging modalities such as fundus photography or OCT compared to brain imaging modalities such as magnetic resonance imaging or positron emission tomography. The purpose of this article is to review and synthesize current research about retinal imaging in neurodegenerative disease by providing examples from the literature and elaborating on limitations, challenges and future directions. We begin by providing a general background of the most relevant retinal imaging modalities to ensure that the reader has a foundation on which to understand the clinical studies that are subsequently discussed. We then review the application and results of retinal imaging methodologies to several prevalent neurodegenerative diseases where extensive work has been done including sporadic late onset Alzheimer's Disease, Parkinson's Disease and Huntington's Disease. We also discuss Autosomal Dominant Alzheimer's Disease and cerebrovascular small vessel disease, where the application of retinal imaging holds promise but data is currently scarce. Although cerebrovascular disease is not generally considered a neurodegenerative process, it is both a confounder and contributor to neurodegenerative disease processes that requires more attention. Finally, we discuss ongoing efforts to overcome the limitations in the field and unmet clinical and scientific needs.

Authors+Show Affiliations

USC Roski Eye Institute and Department of Ophthalmology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA; USC Ginsburg Institute for Biomedical Therapeutics, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA. Electronic address: akashan1@jhmi.edu.Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.Doheny Eye Institute, University of California, Los Angeles, Los Angeles, CA, USA.USC Roski Eye Institute and Department of Ophthalmology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.USC Roski Eye Institute and Department of Ophthalmology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.Department of Neurology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.Department of Neurology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33460813

Citation

Kashani, Amir H., et al. "Past, Present and Future Role of Retinal Imaging in Neurodegenerative Disease." Progress in Retinal and Eye Research, vol. 83, 2021, p. 100938.
Kashani AH, Asanad S, Chan JW, et al. Past, present and future role of retinal imaging in neurodegenerative disease. Prog Retin Eye Res. 2021;83:100938.
Kashani, A. H., Asanad, S., Chan, J. W., Singer, M. B., Zhang, J., Sharifi, M., Khansari, M. M., Abdolahi, F., Shi, Y., Biffi, A., Chui, H., & Ringman, J. M. (2021). Past, present and future role of retinal imaging in neurodegenerative disease. Progress in Retinal and Eye Research, 83, 100938. https://doi.org/10.1016/j.preteyeres.2020.100938
Kashani AH, et al. Past, Present and Future Role of Retinal Imaging in Neurodegenerative Disease. Prog Retin Eye Res. 2021;83:100938. PubMed PMID: 33460813.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Past, present and future role of retinal imaging in neurodegenerative disease. AU - Kashani,Amir H, AU - Asanad,Samuel, AU - Chan,Jane W, AU - Singer,Maxwell B, AU - Zhang,Jiong, AU - Sharifi,Mona, AU - Khansari,Maziyar M, AU - Abdolahi,Farzan, AU - Shi,Yonggang, AU - Biffi,Alessandro, AU - Chui,Helena, AU - Ringman,John M, Y1 - 2021/01/15/ PY - 2020/08/21/received PY - 2020/12/11/revised PY - 2020/12/17/accepted PY - 2022/07/01/pmc-release PY - 2021/1/19/pubmed PY - 2021/1/19/medline PY - 2021/1/18/entrez KW - Alzheimer's disease KW - Cerebral small vessel disease KW - Huntington's disease KW - Imaging KW - Parkinson's disease KW - Retina SP - 100938 EP - 100938 JF - Progress in retinal and eye research JO - Prog Retin Eye Res VL - 83 N2 - Retinal imaging technology is rapidly advancing and can provide ever-increasing amounts of information about the structure, function and molecular composition of retinal tissue in humans in vivo. Most importantly, this information can be obtained rapidly, non-invasively and in many cases using Food and Drug Administration-approved devices that are commercially available. Technologies such as optical coherence tomography have dramatically changed our understanding of retinal disease and in many cases have significantly improved their clinical management. Since the retina is an extension of the brain and shares a common embryological origin with the central nervous system, there has also been intense interest in leveraging the expanding armamentarium of retinal imaging technology to understand, diagnose and monitor neurological diseases. This is particularly appealing because of the high spatial resolution, relatively low-cost and wide availability of retinal imaging modalities such as fundus photography or OCT compared to brain imaging modalities such as magnetic resonance imaging or positron emission tomography. The purpose of this article is to review and synthesize current research about retinal imaging in neurodegenerative disease by providing examples from the literature and elaborating on limitations, challenges and future directions. We begin by providing a general background of the most relevant retinal imaging modalities to ensure that the reader has a foundation on which to understand the clinical studies that are subsequently discussed. We then review the application and results of retinal imaging methodologies to several prevalent neurodegenerative diseases where extensive work has been done including sporadic late onset Alzheimer's Disease, Parkinson's Disease and Huntington's Disease. We also discuss Autosomal Dominant Alzheimer's Disease and cerebrovascular small vessel disease, where the application of retinal imaging holds promise but data is currently scarce. Although cerebrovascular disease is not generally considered a neurodegenerative process, it is both a confounder and contributor to neurodegenerative disease processes that requires more attention. Finally, we discuss ongoing efforts to overcome the limitations in the field and unmet clinical and scientific needs. SN - 1873-1635 UR - https://www.unboundmedicine.com/medline/citation/33460813/Past,_present_and_future_role_of_retinal_imaging_in_neurodegenerative_disease. L2 - https://linkinghub.elsevier.com/retrieve/pii/S1350-9462(20)30110-5 DB - PRIME DP - Unbound Medicine ER -
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