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Subclinical Auditory Dysfunction: Relationship Between Distortion Product Otoacoustic Emissions and the Audiogram.
Am J Audiol. 2021 Oct 11; 30(3S):854-869.AJ

Abstract

Purpose Distortion product otoacoustic emissions (DPOAEs) and audiometric thresholds have been used to account for the impacts of subclinical outer hair cell (OHC) dysfunction on auditory perception and measures of auditory physiology. However, the relationship between DPOAEs and the audiogram is unclear. This study investigated this relationship by determining how well DPOAE levels can predict the audiogram among individuals with clinically normal hearing. Additionally, the impacts of age, noise exposure, and the perception of tinnitus on the ability of DPOAE levels to predict the audiogram were evaluated. Method Suprathreshold DPOAE levels from 1 to 10 kHz and pure-tone thresholds from 0.25 to 16 kHz were measured in 366 ears from 194 young adults (19-35 years old) with clinically normal audiograms and middle ear function. The measured DPOAE levels at all frequencies were used to predict pure-tone thresholds at each frequency. Participants were grouped by age, self-reported noise exposure/Veteran status, and self-report of tinnitus. Results Including DPOAE levels in the pure-tone threshold prediction model improved threshold predictions at all frequencies from 0.25 to 16 kHz compared with a model based only on sample mean pure-tone thresholds, but these improvements were modest. DPOAE levels for f 2 frequencies of 4 and 5 kHz were particularly influential in predicting pure-tone thresholds above 4 kHz. However, prediction accuracy varied based on participant characteristics. On average, predicted pure-tone thresholds were better than measured thresholds among Veterans, individuals with tinnitus, and the oldest age group. Conclusions These results indicate a complex relationship between DPOAE levels and the audiogram. Underestimation of pure-tone thresholds for some groups suggests that additional factors other than OHC damage may impact thresholds among individuals within these categories. These findings suggest that DPOAE levels and pure-tone thresholds may differ in terms of how well they reflect subclinical OHC dysfunction. Supplemental Material https://doi.org/10.23641/asha.13564745.

Authors+Show Affiliations

VA RR&D National Center for Rehabilitative Auditory Research, VA Portland Health Care System, OR. Department of Otolaryngology-Head & Neck Surgery, Oregon Health and Science University, Portland.VA RR&D National Center for Rehabilitative Auditory Research, VA Portland Health Care System, OR. Department of Otolaryngology-Head & Neck Surgery, Oregon Health and Science University, Portland.VA RR&D National Center for Rehabilitative Auditory Research, VA Portland Health Care System, OR. Department of Audiology and Speech Pathology, University of Tennessee Health Science Center, Knoxville.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33465327

Citation

Bramhall, Naomi F., et al. "Subclinical Auditory Dysfunction: Relationship Between Distortion Product Otoacoustic Emissions and the Audiogram." American Journal of Audiology, vol. 30, no. 3S, 2021, pp. 854-869.
Bramhall NF, McMillan GP, Mashburn AN. Subclinical Auditory Dysfunction: Relationship Between Distortion Product Otoacoustic Emissions and the Audiogram. Am J Audiol. 2021;30(3S):854-869.
Bramhall, N. F., McMillan, G. P., & Mashburn, A. N. (2021). Subclinical Auditory Dysfunction: Relationship Between Distortion Product Otoacoustic Emissions and the Audiogram. American Journal of Audiology, 30(3S), 854-869. https://doi.org/10.1044/2020_AJA-20-00056
Bramhall NF, McMillan GP, Mashburn AN. Subclinical Auditory Dysfunction: Relationship Between Distortion Product Otoacoustic Emissions and the Audiogram. Am J Audiol. 2021 Oct 11;30(3S):854-869. PubMed PMID: 33465327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subclinical Auditory Dysfunction: Relationship Between Distortion Product Otoacoustic Emissions and the Audiogram. AU - Bramhall,Naomi F, AU - McMillan,Garnett P, AU - Mashburn,Amy N, Y1 - 2021/01/19/ PY - 2021/1/20/pubmed PY - 2021/11/25/medline PY - 2021/1/19/entrez SP - 854 EP - 869 JF - American journal of audiology JO - Am J Audiol VL - 30 IS - 3S N2 - Purpose Distortion product otoacoustic emissions (DPOAEs) and audiometric thresholds have been used to account for the impacts of subclinical outer hair cell (OHC) dysfunction on auditory perception and measures of auditory physiology. However, the relationship between DPOAEs and the audiogram is unclear. This study investigated this relationship by determining how well DPOAE levels can predict the audiogram among individuals with clinically normal hearing. Additionally, the impacts of age, noise exposure, and the perception of tinnitus on the ability of DPOAE levels to predict the audiogram were evaluated. Method Suprathreshold DPOAE levels from 1 to 10 kHz and pure-tone thresholds from 0.25 to 16 kHz were measured in 366 ears from 194 young adults (19-35 years old) with clinically normal audiograms and middle ear function. The measured DPOAE levels at all frequencies were used to predict pure-tone thresholds at each frequency. Participants were grouped by age, self-reported noise exposure/Veteran status, and self-report of tinnitus. Results Including DPOAE levels in the pure-tone threshold prediction model improved threshold predictions at all frequencies from 0.25 to 16 kHz compared with a model based only on sample mean pure-tone thresholds, but these improvements were modest. DPOAE levels for f 2 frequencies of 4 and 5 kHz were particularly influential in predicting pure-tone thresholds above 4 kHz. However, prediction accuracy varied based on participant characteristics. On average, predicted pure-tone thresholds were better than measured thresholds among Veterans, individuals with tinnitus, and the oldest age group. Conclusions These results indicate a complex relationship between DPOAE levels and the audiogram. Underestimation of pure-tone thresholds for some groups suggests that additional factors other than OHC damage may impact thresholds among individuals within these categories. These findings suggest that DPOAE levels and pure-tone thresholds may differ in terms of how well they reflect subclinical OHC dysfunction. Supplemental Material https://doi.org/10.23641/asha.13564745. SN - 1558-9137 UR - https://www.unboundmedicine.com/medline/citation/33465327/Subclinical_Auditory_Dysfunction:_Relationship_Between_Distortion_Product_Otoacoustic_Emissions_and_the_Audiogram_ L2 - https://pubs.asha.org/doi/10.1044/2020_AJA-20-00056?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -