Tags

Type your tag names separated by a space and hit enter

A fully screen-printed potentiometric chloride ion sensor employing a hydrogel-based touchpad for simple and non-invasive daily electrolyte analysis.
Anal Bioanal Chem. 2021 Mar; 413(7):1883-1891.AB

Abstract

This is the first report demonstrating proof of concept for the passive, non-invasive extraction and in situ potentiometric detection of human sweat chloride ions (Cl- ions) using a stable printed planar liquid-junction reference electrode-integrated hydrogel-based touch-sensor pad without activities such as exercise to induce perspiration, environmental temperature control, or requiring cholinergic drug administration. The sensor pad was composed entirely of a screen-printed bare Ag/AgCl-based chloride ion-selective electrode and a planar liquid-junction Ag/AgCl reference electrode, which were fully covered by an agarose hydrogel in phosphate-buffered saline (PBS). When human skin contacted the hydrogel pad, sweat Cl- ions were continuously extracted into the gel, followed by in situ potentiometric detection. The planar liquid-junction Ag/AgCl reference electrode had a polymer-based KCl-saturated inner electrolyte layer to stabilize the potential of the Ag/AgCl electrode even with a substantial change in the chloride ion concentration in the hydrogel pad. We expect this fully screen-printed sensor to achieve the low-cost passive and non-invasive daily monitoring of human Cl- ions in sweat in the future.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Ichimura Y
Graduate School of Organic Materials Science, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata, 992-8510, Japan.
Kuritsubo T
Graduate School of Organic Materials Science, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata, 992-8510, Japan.
Nagamine K
Graduate School of Organic Materials Science, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata, 992-8510, Japan. nagamine@yz.yamagata-u.ac.jp. Research Center of Organic Electronics (ROEL), Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata, 992-8510, Japan. nagamine@yz.yamagata-u.ac.jp.
Nomura A
Research Center of Organic Electronics (ROEL), Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata, 992-8510, Japan.
Shitanda I
Research Center of Organic Electronics (ROEL), Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata, 992-8510, Japan. Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba, 278-8510, Japan.
Tokito S
Graduate School of Organic Materials Science, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata, 992-8510, Japan. tokito@yz.yamagata-u.ac.jp. Research Center of Organic Electronics (ROEL), Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata, 992-8510, Japan. tokito@yz.yamagata-u.ac.jp.

MeSH

Biosensing TechniquesChloridesCholinergic AgentsElectrochemistryElectrodesElectrolytesEquipment DesignHumansHydrogelsIon-Selective ElectrodesIonsPolymersPotentiometrySepharoseSkinSweatTemperature

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33479820

Citation

Ichimura, Yusuke, et al. "A Fully Screen-printed Potentiometric Chloride Ion Sensor Employing a Hydrogel-based Touchpad for Simple and Non-invasive Daily Electrolyte Analysis." Analytical and Bioanalytical Chemistry, vol. 413, no. 7, 2021, pp. 1883-1891.
Ichimura Y, Kuritsubo T, Nagamine K, et al. A fully screen-printed potentiometric chloride ion sensor employing a hydrogel-based touchpad for simple and non-invasive daily electrolyte analysis. Anal Bioanal Chem. 2021;413(7):1883-1891.
Ichimura, Y., Kuritsubo, T., Nagamine, K., Nomura, A., Shitanda, I., & Tokito, S. (2021). A fully screen-printed potentiometric chloride ion sensor employing a hydrogel-based touchpad for simple and non-invasive daily electrolyte analysis. Analytical and Bioanalytical Chemistry, 413(7), 1883-1891. https://doi.org/10.1007/s00216-021-03156-3
Ichimura Y, et al. A Fully Screen-printed Potentiometric Chloride Ion Sensor Employing a Hydrogel-based Touchpad for Simple and Non-invasive Daily Electrolyte Analysis. Anal Bioanal Chem. 2021;413(7):1883-1891. PubMed PMID: 33479820.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A fully screen-printed potentiometric chloride ion sensor employing a hydrogel-based touchpad for simple and non-invasive daily electrolyte analysis. AU - Ichimura,Yusuke, AU - Kuritsubo,Takumi, AU - Nagamine,Kuniaki, AU - Nomura,Ayako, AU - Shitanda,Isao, AU - Tokito,Shizuo, Y1 - 2021/01/22/ PY - 2020/03/05/received PY - 2021/01/05/accepted PY - 2020/12/23/revised PY - 2021/1/23/pubmed PY - 2021/8/3/medline PY - 2021/1/22/entrez KW - Biosensor KW - Healthcare KW - Hydrogel KW - Printed electronics KW - Sweat analysis SP - 1883 EP - 1891 JF - Analytical and bioanalytical chemistry JO - Anal Bioanal Chem VL - 413 IS - 7 N2 - This is the first report demonstrating proof of concept for the passive, non-invasive extraction and in situ potentiometric detection of human sweat chloride ions (Cl- ions) using a stable printed planar liquid-junction reference electrode-integrated hydrogel-based touch-sensor pad without activities such as exercise to induce perspiration, environmental temperature control, or requiring cholinergic drug administration. The sensor pad was composed entirely of a screen-printed bare Ag/AgCl-based chloride ion-selective electrode and a planar liquid-junction Ag/AgCl reference electrode, which were fully covered by an agarose hydrogel in phosphate-buffered saline (PBS). When human skin contacted the hydrogel pad, sweat Cl- ions were continuously extracted into the gel, followed by in situ potentiometric detection. The planar liquid-junction Ag/AgCl reference electrode had a polymer-based KCl-saturated inner electrolyte layer to stabilize the potential of the Ag/AgCl electrode even with a substantial change in the chloride ion concentration in the hydrogel pad. We expect this fully screen-printed sensor to achieve the low-cost passive and non-invasive daily monitoring of human Cl- ions in sweat in the future. SN - 1618-2650 UR - https://www.unboundmedicine.com/medline/citation/33479820/A_fully_screen_printed_potentiometric_chloride_ion_sensor_employing_a_hydrogel_based_touchpad_for_simple_and_non_invasive_daily_electrolyte_analysis_ DB - PRIME DP - Unbound Medicine ER -