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Effects of repeated weight loss and regain on body composition in obese rats.
Am J Clin Nutr. 1988 Mar; 47(3):393-9.AJ

Abstract

To test the hypothesis that repeated loss and gain of weight through dieting will result in increasing fatness, 200-g female Sprague-Dawley rats were castrated and allowed to become obese on a high-fat diet for 6 wk. Two successive periods of severe food restriction (50% maintenance for 28 d and 25% maintenance for 21 d) were each followed by ad libitum refeeding on the high-fat diet until control body weights were attained. Percent body fat was determined indirectly from body density and total-body water at the end of each cycle. Restricted rats gained weight and attained control body weights on ad libitum feeding without overshooting these weights, and percentage body fat was not different from that of controls at the end of either cycle (cycle 1 22.3 +/- 1.7 vs 23.8 +/- 1.7%; cycle 2 19.0 +/- 1.1 vs 21.6 +/- 0.8%). Repeated cycles of weight loss and regain do not produce increased body fatness or decreased rate of weight loss in ovariectomized rats.

Authors+Show Affiliations

Department of Medicine, University of Southern California, Los Angeles.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3348151

Citation

Gray, D S., et al. "Effects of Repeated Weight Loss and Regain On Body Composition in Obese Rats." The American Journal of Clinical Nutrition, vol. 47, no. 3, 1988, pp. 393-9.
Gray DS, Fisler JS, Bray GA. Effects of repeated weight loss and regain on body composition in obese rats. Am J Clin Nutr. 1988;47(3):393-9.
Gray, D. S., Fisler, J. S., & Bray, G. A. (1988). Effects of repeated weight loss and regain on body composition in obese rats. The American Journal of Clinical Nutrition, 47(3), 393-9.
Gray DS, Fisler JS, Bray GA. Effects of Repeated Weight Loss and Regain On Body Composition in Obese Rats. Am J Clin Nutr. 1988;47(3):393-9. PubMed PMID: 3348151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of repeated weight loss and regain on body composition in obese rats. AU - Gray,D S, AU - Fisler,J S, AU - Bray,G A, PY - 1988/3/1/pubmed PY - 1988/3/1/medline PY - 1988/3/1/entrez SP - 393 EP - 9 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 47 IS - 3 N2 - To test the hypothesis that repeated loss and gain of weight through dieting will result in increasing fatness, 200-g female Sprague-Dawley rats were castrated and allowed to become obese on a high-fat diet for 6 wk. Two successive periods of severe food restriction (50% maintenance for 28 d and 25% maintenance for 21 d) were each followed by ad libitum refeeding on the high-fat diet until control body weights were attained. Percent body fat was determined indirectly from body density and total-body water at the end of each cycle. Restricted rats gained weight and attained control body weights on ad libitum feeding without overshooting these weights, and percentage body fat was not different from that of controls at the end of either cycle (cycle 1 22.3 +/- 1.7 vs 23.8 +/- 1.7%; cycle 2 19.0 +/- 1.1 vs 21.6 +/- 0.8%). Repeated cycles of weight loss and regain do not produce increased body fatness or decreased rate of weight loss in ovariectomized rats. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/3348151/Effects_of_repeated_weight_loss_and_regain_on_body_composition_in_obese_rats_ DB - PRIME DP - Unbound Medicine ER -