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Can antibiotic treatment failure in tubo-ovarian abscess be predictable?
Eur J Obstet Gynecol Reprod Biol. 2021 Mar; 258:253-257.EJ

Abstract

INTRODUCTION

We aimed to identify factors that would predict the success of antibiotic treatment and the need for surgical treatment in tubo-ovarian abscess (TOA) patients.

MATERIALS AND METHODS

The data of 146 patients with a diagnosis of TOA were analyzed retrospectively. Patients were separated into two groups; successfully treated with antibiotics and going under surgery after antibiotic treatment failure. Demographic, clinical and laboratory data of patients were examined between both groups that could determine the success of treatment.

RESULTS

In the surgical treatment group, age, body mass index (BMI), and C-reactive protein (CRP) values ​​were higher than the antibiotic treatment group (p = 0.017, p = 0.026, and p < 0.001 respectively). Patients who underwent surgery had a significantly larger abscess than those who received antibiotic therapy (79.4 ± 21.1 mm vs. 50.9 ± 13.2 mm, p < 0.001). Cut-off values of the findings, which were identified as risk factors in predicting the failure of antibiotic treatment, were found with ROC analyses. This cut-off was 41.5 years for age (sensitivity 71.3 %, specificity 60 %), 26.72 kg/m2 for BMI (sensitivity 51.5 %, specificity 71.1 %), and 143.5 mg/L for CRP value on admission (sensitivity 68.3 %, specificity 71.1 %). The cut-off for abscess diameter was 62.5 mm (sensitivity 88.1 %, specificity 82.2 %).

CONCLUSION

Especially in large tubo-ovarian abscesses, early surgical intervention should be preferred considering the age, BMI, and CRP values.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey. Electronic address: burakakselim@hotmail.com.Department of Obstetrics and Gynecology, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey.Department of Obstetrics and Gynecology, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey.Department of Obstetrics and Gynecology, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33482459

Citation

Akselim, Burak, et al. "Can Antibiotic Treatment Failure in Tubo-ovarian Abscess Be Predictable?" European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 258, 2021, pp. 253-257.
Akselim B, Karaşin SS, Demirci A, et al. Can antibiotic treatment failure in tubo-ovarian abscess be predictable? Eur J Obstet Gynecol Reprod Biol. 2021;258:253-257.
Akselim, B., Karaşin, S. S., Demirci, A., & Üstünyurt, E. (2021). Can antibiotic treatment failure in tubo-ovarian abscess be predictable? European Journal of Obstetrics, Gynecology, and Reproductive Biology, 258, 253-257. https://doi.org/10.1016/j.ejogrb.2021.01.011
Akselim B, et al. Can Antibiotic Treatment Failure in Tubo-ovarian Abscess Be Predictable. Eur J Obstet Gynecol Reprod Biol. 2021;258:253-257. PubMed PMID: 33482459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can antibiotic treatment failure in tubo-ovarian abscess be predictable? AU - Akselim,Burak, AU - Karaşin,Süleyman Serkan, AU - Demirci,Ahmet, AU - Üstünyurt,Emin, Y1 - 2021/01/15/ PY - 2020/11/03/received PY - 2020/12/26/revised PY - 2021/01/08/accepted PY - 2021/1/23/pubmed PY - 2021/1/23/medline PY - 2021/1/22/entrez KW - Abscess size KW - Antibiotics KW - Pelvic inflammatory disease KW - Surgery KW - Tubo-ovarian abscess SP - 253 EP - 257 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur J Obstet Gynecol Reprod Biol VL - 258 N2 - INTRODUCTION: We aimed to identify factors that would predict the success of antibiotic treatment and the need for surgical treatment in tubo-ovarian abscess (TOA) patients. MATERIALS AND METHODS: The data of 146 patients with a diagnosis of TOA were analyzed retrospectively. Patients were separated into two groups; successfully treated with antibiotics and going under surgery after antibiotic treatment failure. Demographic, clinical and laboratory data of patients were examined between both groups that could determine the success of treatment. RESULTS: In the surgical treatment group, age, body mass index (BMI), and C-reactive protein (CRP) values ​​were higher than the antibiotic treatment group (p = 0.017, p = 0.026, and p < 0.001 respectively). Patients who underwent surgery had a significantly larger abscess than those who received antibiotic therapy (79.4 ± 21.1 mm vs. 50.9 ± 13.2 mm, p < 0.001). Cut-off values of the findings, which were identified as risk factors in predicting the failure of antibiotic treatment, were found with ROC analyses. This cut-off was 41.5 years for age (sensitivity 71.3 %, specificity 60 %), 26.72 kg/m2 for BMI (sensitivity 51.5 %, specificity 71.1 %), and 143.5 mg/L for CRP value on admission (sensitivity 68.3 %, specificity 71.1 %). The cut-off for abscess diameter was 62.5 mm (sensitivity 88.1 %, specificity 82.2 %). CONCLUSION: Especially in large tubo-ovarian abscesses, early surgical intervention should be preferred considering the age, BMI, and CRP values. SN - 1872-7654 UR - https://www.unboundmedicine.com/medline/citation/33482459/Can_antibiotic_treatment_failure_in_tubo-ovarian_abscess_be_predictable L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-2115(21)00023-3 DB - PRIME DP - Unbound Medicine ER -
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