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Gestation and COVID-19: clinical and microbiological observational study (Gesta-COVID19).
BMC Pregnancy Childbirth. 2021 Jan 22; 21(1):78.BP

Abstract

BACKGROUND

The Coronavirus Disease 2019 (COVID-19) is a novel disease which has been having a worldwide affect since December 2019. Evidence regarding the effects of SARS-CoV-2 during pregnancy is conflicting. The presence of SARS-CoV-2 has been demonstrated in biological samples during pregnancy (placenta, umbilical cord or amniotic fluid); however, maternal and fetal effects of the virus are not well known.

METHODS

Descriptive, multicentre, longitudinal, observational study in eight tertiary care hospitals throughout Spain, that are referral centres for pregnant women with COVID-19. All pregnant women with positive SARS-CoV-2 real-time reverse transcriptase polymerase chain reaction during their pregnancy or 14 days preconception and newborns born to mothers infected with SARS-CoV-2 will be included. They will continue to be followed up until 4 weeks after delivery. The aim of the study is to investigate both the effect of COVID-19 on the pregnancy, and the effect of the pregnancy status with the evolution of the SARS-CoV-2 disease. Other samples (faeces, urine, serum, amniotic fluid, cord and peripheral blood, placenta and breastmilk) will be collected in order to analyse whether or not there is a risk of vertical transmission and to describe the behaviour of the virus in other fluids. Neonates will be followed until 6 months after delivery to establish the rate of neonatal transmission. We aim to include 150 pregnant women and their babies. Ethics approval will be obtained from all the participating centres.

DISCUSSION

There is little information known about COVID-19 and its unknown effects on pregnancy. This study will collect a large number of samples in pregnant women which will allow us to demonstrate the behaviour of the virus in pregnancy and postpartum in a representative cohort of the Spanish population.

Authors+Show Affiliations

Department of Obstetrics, Hospital Universitari Vall d'Hebron, Barcelona, Spain.Department of Obstetrics, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.Department of Obstetrics, Hospital Universitari Vall d'Hebron, Barcelona, Spain.Department of Obstetrics, Hospital Universitari Vall d'Hebron, Barcelona, Spain.Department of Obstetrics, Hospital Universitari Vall d'Hebron, Barcelona, Spain.Department of Obstetrics, Hospital Universitari Vall d'Hebron, Barcelona, Spain. nmaiz@vhebron.net. Maternal-Fetal Medicine Unit, Department of Obstetrics, Vall d'Hebron University Hospital, Ps Vall d'Hebron 119-129, 08035, Barcelona, Spain. nmaiz@vhebron.net.Department of Microbiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.Department of Microbiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.Department of Microbiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain. Red Española de Investigación en Patología Infecciosa (REIPI), Instituto de Salud Carlos III, Madrid, Spain.Department of Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Barcelona, Spain.Department of Neonatology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.Department of Microbiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.Department of Obstetrics, Hospital Universitari Vall d'Hebron, Barcelona, Spain.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33482757

Citation

Suy, Anna, et al. "Gestation and COVID-19: Clinical and Microbiological Observational Study (Gesta-COVID19)." BMC Pregnancy and Childbirth, vol. 21, no. 1, 2021, p. 78.
Suy A, Garcia-Ruiz I, Carbonell M, et al. Gestation and COVID-19: clinical and microbiological observational study (Gesta-COVID19). BMC Pregnancy Childbirth. 2021;21(1):78.
Suy, A., Garcia-Ruiz, I., Carbonell, M., Garcia-Manau, P., Rodo, C., Maiz, N., Sulleiro, E., Anton, A., Esperalba, J., Fernández-Hidalgo, N., Frick, M. A., Camba, F., Pumarola, T., & Carreras, E. (2021). Gestation and COVID-19: clinical and microbiological observational study (Gesta-COVID19). BMC Pregnancy and Childbirth, 21(1), 78. https://doi.org/10.1186/s12884-021-03572-4
Suy A, et al. Gestation and COVID-19: Clinical and Microbiological Observational Study (Gesta-COVID19). BMC Pregnancy Childbirth. 2021 Jan 22;21(1):78. PubMed PMID: 33482757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gestation and COVID-19: clinical and microbiological observational study (Gesta-COVID19). AU - Suy,Anna, AU - Garcia-Ruiz,Itziar, AU - Carbonell,Melchor, AU - Garcia-Manau,Pablo, AU - Rodo,Carlota, AU - Maiz,Nerea, AU - Sulleiro,Elena, AU - Anton,Andres, AU - Esperalba,Juliana, AU - Fernández-Hidalgo,Nuria, AU - Frick,Marie Antoinette, AU - Camba,Fatima, AU - Pumarola,Tomas, AU - Carreras,Elena, AU - ,, Y1 - 2021/01/22/ PY - 2020/04/27/received PY - 2021/01/19/accepted PY - 2021/1/23/entrez PY - 2021/1/24/pubmed PY - 2021/1/29/medline KW - Amniotic fluid KW - Breastmilk KW - COVID-19 KW - Cord blood KW - Placenta KW - Pregnancy KW - SARS-CoV-2 KW - Vertical transmission SP - 78 EP - 78 JF - BMC pregnancy and childbirth JO - BMC Pregnancy Childbirth VL - 21 IS - 1 N2 - BACKGROUND: The Coronavirus Disease 2019 (COVID-19) is a novel disease which has been having a worldwide affect since December 2019. Evidence regarding the effects of SARS-CoV-2 during pregnancy is conflicting. The presence of SARS-CoV-2 has been demonstrated in biological samples during pregnancy (placenta, umbilical cord or amniotic fluid); however, maternal and fetal effects of the virus are not well known. METHODS: Descriptive, multicentre, longitudinal, observational study in eight tertiary care hospitals throughout Spain, that are referral centres for pregnant women with COVID-19. All pregnant women with positive SARS-CoV-2 real-time reverse transcriptase polymerase chain reaction during their pregnancy or 14 days preconception and newborns born to mothers infected with SARS-CoV-2 will be included. They will continue to be followed up until 4 weeks after delivery. The aim of the study is to investigate both the effect of COVID-19 on the pregnancy, and the effect of the pregnancy status with the evolution of the SARS-CoV-2 disease. Other samples (faeces, urine, serum, amniotic fluid, cord and peripheral blood, placenta and breastmilk) will be collected in order to analyse whether or not there is a risk of vertical transmission and to describe the behaviour of the virus in other fluids. Neonates will be followed until 6 months after delivery to establish the rate of neonatal transmission. We aim to include 150 pregnant women and their babies. Ethics approval will be obtained from all the participating centres. DISCUSSION: There is little information known about COVID-19 and its unknown effects on pregnancy. This study will collect a large number of samples in pregnant women which will allow us to demonstrate the behaviour of the virus in pregnancy and postpartum in a representative cohort of the Spanish population. SN - 1471-2393 UR - https://www.unboundmedicine.com/medline/citation/33482757/Gestation_and_COVID_19:_clinical_and_microbiological_observational_study__Gesta_COVID19__ L2 - https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-021-03572-4 DB - PRIME DP - Unbound Medicine ER -