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Effect of intermittent irradiation and fluence-response of 222 nm ultraviolet light on SARS-CoV-2 contamination.
Photodiagnosis Photodyn Ther. 2021 Mar; 33:102184.PP

Abstract

BACKGROUND

The effectiveness of 222 nm ultraviolet (UV) C light for disinfecting surfaces contaminated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported. The aim of this study was to evaluate the effect of the intermittent irradiation of 222 nm UVC on SARS-CoV-2 and the fluence-dependent effect of 222 nm UVC irradiation on SARS-CoV-2 inactivation.

METHODS

We experimented with 5 min continuous and intermittent irradiation for 0.1, 0.05, 0.013, and 0.003 mW/cm2 of 222 nm UVC to evaluate the differences in the effect of the continuous and intermittent irradiation of 222 nm UVC on SARS-CoV-2 inactivation. For intermittent irradiation, we followed the on-off irradiation cycles with every 10-s irradiation followed by a 380-s interval. Thereafter, we evaluated the effects of 0.1, 0.013, and 0.003 mW/cm2 222 nm UVC irradiation on SARS-CoV-2 contamination at UV fluences of 1, 2, and 3 mJ/cm2 at each irradiance.

RESULTS

At each irradiance, no significant difference was observed in the log reduction of SARS-CoV-2 between continuous and intermittent irradiation. At each UV fluence, no significant difference was observed in the log reduction of SARS-CoV-2 among the three different irradiance levels.

CONCLUSION

There was no significant difference between continuous and intermittent irradiation with 222 nm UVC with regards to SARS-CoV-2 inactivation. Moreover, 222 nm UVC inactivates SARS-CoV-2 in a fluence-dependent manner. The efficacy of 222-nm UVC irradiation in reducing the contamination of SARS-CoV-2 needs to be further evaluated in a real-world setting.

Authors+Show Affiliations

Department of Infectious Diseases, Hiroshima University Hospital, Hiroshima, Japan; Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima, Japan; Department of Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.Department of Infectious Diseases, Hiroshima University Hospital, Hiroshima, Japan; Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.Clinical Research Center in Hiroshima, Hiroshima University Hospital, Hiroshima, Japan.Department of Infectious Diseases, Hiroshima University Hospital, Hiroshima, Japan.Department of Infectious Diseases, Hiroshima University Hospital, Hiroshima, Japan; Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima, Japan; Department of Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan; Translational Research Center, Hiroshima University, Hiroshima, Japan.Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.Department of Infectious Diseases, Hiroshima University Hospital, Hiroshima, Japan; Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33484873

Citation

Kitagawa, Hiroki, et al. "Effect of Intermittent Irradiation and Fluence-response of 222 Nm Ultraviolet Light On SARS-CoV-2 Contamination." Photodiagnosis and Photodynamic Therapy, vol. 33, 2021, p. 102184.
Kitagawa H, Nomura T, Nazmul T, et al. Effect of intermittent irradiation and fluence-response of 222 nm ultraviolet light on SARS-CoV-2 contamination. Photodiagnosis Photodyn Ther. 2021;33:102184.
Kitagawa, H., Nomura, T., Nazmul, T., Kawano, R., Omori, K., Shigemoto, N., Sakaguchi, T., & Ohge, H. (2021). Effect of intermittent irradiation and fluence-response of 222 nm ultraviolet light on SARS-CoV-2 contamination. Photodiagnosis and Photodynamic Therapy, 33, 102184. https://doi.org/10.1016/j.pdpdt.2021.102184
Kitagawa H, et al. Effect of Intermittent Irradiation and Fluence-response of 222 Nm Ultraviolet Light On SARS-CoV-2 Contamination. Photodiagnosis Photodyn Ther. 2021;33:102184. PubMed PMID: 33484873.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of intermittent irradiation and fluence-response of 222 nm ultraviolet light on SARS-CoV-2 contamination. AU - Kitagawa,Hiroki, AU - Nomura,Toshihito, AU - Nazmul,Tanuza, AU - Kawano,Reo, AU - Omori,Keitaro, AU - Shigemoto,Norifumi, AU - Sakaguchi,Takemasa, AU - Ohge,Hiroki, Y1 - 2021/01/20/ PY - 2020/11/26/received PY - 2021/01/01/revised PY - 2021/01/08/accepted PY - 2021/1/24/pubmed PY - 2021/1/24/medline PY - 2021/1/23/entrez KW - Decontamination KW - Disinfection KW - Far-UVC KW - SARS-CoV-2 KW - Ultraviolet light SP - 102184 EP - 102184 JF - Photodiagnosis and photodynamic therapy JO - Photodiagnosis Photodyn Ther VL - 33 N2 - BACKGROUND: The effectiveness of 222 nm ultraviolet (UV) C light for disinfecting surfaces contaminated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported. The aim of this study was to evaluate the effect of the intermittent irradiation of 222 nm UVC on SARS-CoV-2 and the fluence-dependent effect of 222 nm UVC irradiation on SARS-CoV-2 inactivation. METHODS: We experimented with 5 min continuous and intermittent irradiation for 0.1, 0.05, 0.013, and 0.003 mW/cm2 of 222 nm UVC to evaluate the differences in the effect of the continuous and intermittent irradiation of 222 nm UVC on SARS-CoV-2 inactivation. For intermittent irradiation, we followed the on-off irradiation cycles with every 10-s irradiation followed by a 380-s interval. Thereafter, we evaluated the effects of 0.1, 0.013, and 0.003 mW/cm2 222 nm UVC irradiation on SARS-CoV-2 contamination at UV fluences of 1, 2, and 3 mJ/cm2 at each irradiance. RESULTS: At each irradiance, no significant difference was observed in the log reduction of SARS-CoV-2 between continuous and intermittent irradiation. At each UV fluence, no significant difference was observed in the log reduction of SARS-CoV-2 among the three different irradiance levels. CONCLUSION: There was no significant difference between continuous and intermittent irradiation with 222 nm UVC with regards to SARS-CoV-2 inactivation. Moreover, 222 nm UVC inactivates SARS-CoV-2 in a fluence-dependent manner. The efficacy of 222-nm UVC irradiation in reducing the contamination of SARS-CoV-2 needs to be further evaluated in a real-world setting. SN - 1873-1597 UR - https://www.unboundmedicine.com/medline/citation/33484873/Effect_of_intermittent_irradiation_and_fluence_response_of_222_nm_ultraviolet_light_on_SARS_CoV_2_contamination_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1572-1000(21)00010-7 DB - PRIME DP - Unbound Medicine ER -