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The Cytokine Profiles and Immune Response Are Increased in COVID-19 Patients with Type 2 Diabetes Mellitus.
J Diabetes Res. 2021; 2021:9526701.JD

Abstract

The induction of inflammation and cytokine storm was proposed to play a critical role in COVID-19. This study is aimed at investigating the relationship between glucose metabolism and the inflammatory state of inpatients with COVID-19. 71 inpatients with COVID-19 were classified into nondiabetes mellitus (NDM) group, impaired fasting glucose (IFG) group, and diabetes mellitus (DM) group. The average hospitalization days were significantly shorter in DM patients when compared with patients in the IFG group and NDM group. CD4+ T cell percentage was higher while CD8+ T cells percentage was lower in the DM group than those in the NDM group. The serum levels of IL-6, IL-2, IL-10, and INF-γ in the DM group were upregulated when compared with those in the NDM group. The serum levels of TNF-α, IL-4, IL-2, IL-10, and INF-γ were significantly higher in the DM group than those in the IFG group. A significant difference was observed in CD4+ T cell, CD4+/CD8+ ratio percentage, IL-6, and IL-10 between the NDM group and DM group with adjusted BMI. In conclusion, COVID-19 patients with elevated glucose levels have promoted cytokine profiles and immune response.

Authors+Show Affiliations

The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230031, China.Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, China.Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.Department of Pathophysiology, Anhui Medical University, Hefei, Anhui 230032, China.The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.Department of Pathophysiology, Anhui Medical University, Hefei, Anhui 230032, China.The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

33490288

Citation

Zheng, Mao, et al. "The Cytokine Profiles and Immune Response Are Increased in COVID-19 Patients With Type 2 Diabetes Mellitus." Journal of Diabetes Research, vol. 2021, 2021, p. 9526701.
Zheng M, Wang X, Guo H, et al. The Cytokine Profiles and Immune Response Are Increased in COVID-19 Patients with Type 2 Diabetes Mellitus. J Diabetes Res. 2021;2021:9526701.
Zheng, M., Wang, X., Guo, H., Fan, Y., Song, Z., Lu, Z., Wang, J., Zheng, C., Dong, L., Ma, Y., Zhu, Y., Fang, H., & Ye, S. (2021). The Cytokine Profiles and Immune Response Are Increased in COVID-19 Patients with Type 2 Diabetes Mellitus. Journal of Diabetes Research, 2021, 9526701. https://doi.org/10.1155/2021/9526701
Zheng M, et al. The Cytokine Profiles and Immune Response Are Increased in COVID-19 Patients With Type 2 Diabetes Mellitus. J Diabetes Res. 2021;2021:9526701. PubMed PMID: 33490288.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Cytokine Profiles and Immune Response Are Increased in COVID-19 Patients with Type 2 Diabetes Mellitus. AU - Zheng,Mao, AU - Wang,Xiaobing, AU - Guo,Hui, AU - Fan,Yinguang, AU - Song,Zichen, AU - Lu,Zhaohui, AU - Wang,Jinquan, AU - Zheng,Changcheng, AU - Dong,Lin, AU - Ma,Yan, AU - Zhu,Yuyou, AU - Fang,Haoshu, AU - Ye,Shandong, Y1 - 2021/01/02/ PY - 2020/06/29/received PY - 2020/09/24/revised PY - 2020/10/14/accepted PY - 2021/1/25/entrez PY - 2021/1/26/pubmed PY - 2021/1/28/medline SP - 9526701 EP - 9526701 JF - Journal of diabetes research JO - J Diabetes Res VL - 2021 N2 - The induction of inflammation and cytokine storm was proposed to play a critical role in COVID-19. This study is aimed at investigating the relationship between glucose metabolism and the inflammatory state of inpatients with COVID-19. 71 inpatients with COVID-19 were classified into nondiabetes mellitus (NDM) group, impaired fasting glucose (IFG) group, and diabetes mellitus (DM) group. The average hospitalization days were significantly shorter in DM patients when compared with patients in the IFG group and NDM group. CD4+ T cell percentage was higher while CD8+ T cells percentage was lower in the DM group than those in the NDM group. The serum levels of IL-6, IL-2, IL-10, and INF-γ in the DM group were upregulated when compared with those in the NDM group. The serum levels of TNF-α, IL-4, IL-2, IL-10, and INF-γ were significantly higher in the DM group than those in the IFG group. A significant difference was observed in CD4+ T cell, CD4+/CD8+ ratio percentage, IL-6, and IL-10 between the NDM group and DM group with adjusted BMI. In conclusion, COVID-19 patients with elevated glucose levels have promoted cytokine profiles and immune response. SN - 2314-6753 UR - https://www.unboundmedicine.com/medline/citation/33490288/The_Cytokine_Profiles_and_Immune_Response_Are_Increased_in_COVID_19_Patients_with_Type_2_Diabetes_Mellitus_ L2 - https://doi.org/10.1155/2021/9526701 DB - PRIME DP - Unbound Medicine ER -