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Sensitive and reliable identification of fentanyl citrate in urine and serum using chloride ion-treated paper-based SERS substrate.
Spectrochim Acta A Mol Biomol Spectrosc. 2021 Apr 15; 251:119463.SA

Abstract

Recently, the phenomenon of fentanyls overdose leading to death is emerging in an endless stream. There is an urgent requirement to quickly identify fentanyl content in body fluids for medical and judicial purposes. With this in mind, we present a paper-based SERS substrate decorated with uniform gold nanospheres treated by chloride ion for the detection of fentanyl citrate in urine and serum. In particular, the paper-based SERS sensor was prepared by liquid/liquid self-assembly technique and chloride ion was introduced to clean and modify the substrate surface, which improved the sensitivity of the solid substrate with an enhancement factor (EF) as high as 1.64 × 105. Moreover, the uniformity of each paper-based substrate and the repeatability on different batches of substrate were excellent, and there was no obvious change in the intensity response of Raman spectra within a month. As a result, the quantitative analysis of fentanyl citrate in artificial urine and rat serum were performed based on the modified paper-based substrate with the limit of detection as low as 0.59 μg/mL and 2.78 μg/mL, respectively. Both the concentrations of the two biological samples with the Raman signal intensity were linearly plotted and the recovery of the spiked samples with different concentrations was collected to verify the accuracy of the quantitative curves. All the results suggest that this work makes SERS method available for the rapid identification and quantitative analysis of illicit drug in the real biological samples.

Authors+Show Affiliations

National Key Laboratory of Science and Technology on Tunable Laser, Harbin Institute of Technology, Harbin 150080, PR China; Affiliated Hospital of Inner Mongolia University for the Nationalities, Inner Mongolia, Tongliao 028007, PR China.National Key Laboratory of Science and Technology on Tunable Laser, Harbin Institute of Technology, Harbin 150080, PR China.National Key Laboratory of Science and Technology on Tunable Laser, Harbin Institute of Technology, Harbin 150080, PR China; School of Physics and Materials Engineering, Dalian Minzu University, Dalian 116600, PR China. Electronic address: lin808208@163.com.National Key Laboratory of Science and Technology on Tunable Laser, Harbin Institute of Technology, Harbin 150080, PR China.National Key Laboratory of Science and Technology on Tunable Laser, Harbin Institute of Technology, Harbin 150080, PR China. Electronic address: hasiwuliji@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33493937

Citation

Han, Siqingaowa, et al. "Sensitive and Reliable Identification of Fentanyl Citrate in Urine and Serum Using Chloride Ion-treated Paper-based SERS Substrate." Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, vol. 251, 2021, p. 119463.
Han S, Zhang C, Lin S, et al. Sensitive and reliable identification of fentanyl citrate in urine and serum using chloride ion-treated paper-based SERS substrate. Spectrochim Acta A Mol Biomol Spectrosc. 2021;251:119463.
Han, S., Zhang, C., Lin, S., Sha, X., & Hasi, W. (2021). Sensitive and reliable identification of fentanyl citrate in urine and serum using chloride ion-treated paper-based SERS substrate. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 251, 119463. https://doi.org/10.1016/j.saa.2021.119463
Han S, et al. Sensitive and Reliable Identification of Fentanyl Citrate in Urine and Serum Using Chloride Ion-treated Paper-based SERS Substrate. Spectrochim Acta A Mol Biomol Spectrosc. 2021 Apr 15;251:119463. PubMed PMID: 33493937.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sensitive and reliable identification of fentanyl citrate in urine and serum using chloride ion-treated paper-based SERS substrate. AU - Han,Siqingaowa, AU - Zhang,Chen, AU - Lin,Shuang, AU - Sha,Xuanyu, AU - Hasi,Wuliji, Y1 - 2021/01/13/ PY - 2020/11/03/received PY - 2020/12/29/revised PY - 2021/01/07/accepted PY - 2021/1/26/pubmed PY - 2021/5/15/medline PY - 2021/1/25/entrez KW - Chloride ion KW - Fentanyl citrate KW - Paper-based substrate KW - Serum KW - Surface enhanced Raman scattering KW - Urine SP - 119463 EP - 119463 JF - Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy JO - Spectrochim Acta A Mol Biomol Spectrosc VL - 251 N2 - Recently, the phenomenon of fentanyls overdose leading to death is emerging in an endless stream. There is an urgent requirement to quickly identify fentanyl content in body fluids for medical and judicial purposes. With this in mind, we present a paper-based SERS substrate decorated with uniform gold nanospheres treated by chloride ion for the detection of fentanyl citrate in urine and serum. In particular, the paper-based SERS sensor was prepared by liquid/liquid self-assembly technique and chloride ion was introduced to clean and modify the substrate surface, which improved the sensitivity of the solid substrate with an enhancement factor (EF) as high as 1.64 × 105. Moreover, the uniformity of each paper-based substrate and the repeatability on different batches of substrate were excellent, and there was no obvious change in the intensity response of Raman spectra within a month. As a result, the quantitative analysis of fentanyl citrate in artificial urine and rat serum were performed based on the modified paper-based substrate with the limit of detection as low as 0.59 μg/mL and 2.78 μg/mL, respectively. Both the concentrations of the two biological samples with the Raman signal intensity were linearly plotted and the recovery of the spiked samples with different concentrations was collected to verify the accuracy of the quantitative curves. All the results suggest that this work makes SERS method available for the rapid identification and quantitative analysis of illicit drug in the real biological samples. SN - 1873-3557 UR - https://www.unboundmedicine.com/medline/citation/33493937/Sensitive_and_reliable_identification_of_fentanyl_citrate_in_urine_and_serum_using_chloride_ion_treated_paper_based_SERS_substrate_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-1425(21)00039-1 DB - PRIME DP - Unbound Medicine ER -