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Every breath you take: Impacts of environmental dust exposure on intestinal barrier function-from the gut-lung axis to COVID-19.
Am J Physiol Gastrointest Liver Physiol. 2021 04 01; 320(4):G586-G600.AJ

Abstract

As countries continue to industrialize, major cities experience diminished air quality, whereas rural populations also experience poor air quality from sources such as agricultural operations. These exposures to environmental pollution from both rural and populated/industrialized sources have adverse effects on human health. Although respiratory diseases (e.g., asthma and chronic obstructive pulmonary disease) are the most commonly reported following long-term exposure to particulate matter and hazardous chemicals, gastrointestinal complications have also been associated with the increased risk of lung disease from inhalation of polluted air. The interconnectedness of these organ systems has offered valuable insights into the roles of the immune system and the micro/mycobiota as mediators of communication between the lung and the gut during disease states. A topical example of this relationship is provided by reports of multiple gastrointestinal symptoms in patients with coronavirus disease 2019 (COVID-19), whereas the rapid transmission and increased risk of COVID-19 has been linked to poor air quality and high levels of particulate matter. In this review, we focus on the mechanistic effects of environmental pollution on disease progression with special emphasis on the gut-lung axis.

Authors+Show Affiliations

Division of Biomedical Sciences, School of Medicine, University of California, Riverside, California.Division of Biomedical Sciences, School of Medicine, University of California, Riverside, California.Division of Biomedical Sciences, School of Medicine, University of California, Riverside, California.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

33501887

Citation

Crawford, Meli'sa S., et al. "Every Breath You Take: Impacts of Environmental Dust Exposure On Intestinal Barrier Function-from the Gut-lung Axis to COVID-19." American Journal of Physiology. Gastrointestinal and Liver Physiology, vol. 320, no. 4, 2021, pp. G586-G600.
Crawford MS, Nordgren TM, McCole DF. Every breath you take: Impacts of environmental dust exposure on intestinal barrier function-from the gut-lung axis to COVID-19. Am J Physiol Gastrointest Liver Physiol. 2021;320(4):G586-G600.
Crawford, M. S., Nordgren, T. M., & McCole, D. F. (2021). Every breath you take: Impacts of environmental dust exposure on intestinal barrier function-from the gut-lung axis to COVID-19. American Journal of Physiology. Gastrointestinal and Liver Physiology, 320(4), G586-G600. https://doi.org/10.1152/ajpgi.00423.2020
Crawford MS, Nordgren TM, McCole DF. Every Breath You Take: Impacts of Environmental Dust Exposure On Intestinal Barrier Function-from the Gut-lung Axis to COVID-19. Am J Physiol Gastrointest Liver Physiol. 2021 04 1;320(4):G586-G600. PubMed PMID: 33501887.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Every breath you take: Impacts of environmental dust exposure on intestinal barrier function-from the gut-lung axis to COVID-19. AU - Crawford,Meli'sa S, AU - Nordgren,Tara M, AU - McCole,Declan F, Y1 - 2021/01/27/ PY - 2021/1/28/pubmed PY - 2021/4/20/medline PY - 2021/1/27/entrez KW - COVID-19 KW - air pollution KW - gut KW - intestinal barrier KW - lung SP - G586 EP - G600 JF - American journal of physiology. Gastrointestinal and liver physiology JO - Am J Physiol Gastrointest Liver Physiol VL - 320 IS - 4 N2 - As countries continue to industrialize, major cities experience diminished air quality, whereas rural populations also experience poor air quality from sources such as agricultural operations. These exposures to environmental pollution from both rural and populated/industrialized sources have adverse effects on human health. Although respiratory diseases (e.g., asthma and chronic obstructive pulmonary disease) are the most commonly reported following long-term exposure to particulate matter and hazardous chemicals, gastrointestinal complications have also been associated with the increased risk of lung disease from inhalation of polluted air. The interconnectedness of these organ systems has offered valuable insights into the roles of the immune system and the micro/mycobiota as mediators of communication between the lung and the gut during disease states. A topical example of this relationship is provided by reports of multiple gastrointestinal symptoms in patients with coronavirus disease 2019 (COVID-19), whereas the rapid transmission and increased risk of COVID-19 has been linked to poor air quality and high levels of particulate matter. In this review, we focus on the mechanistic effects of environmental pollution on disease progression with special emphasis on the gut-lung axis. SN - 1522-1547 UR - https://www.unboundmedicine.com/medline/citation/33501887/Every_breath_you_take:_Impacts_of_environmental_dust_exposure_on_intestinal_barrier_function_from_the_gut_lung_axis_to_COVID_19_ L2 - https://journals.physiology.org/doi/10.1152/ajpgi.00423.2020?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -