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Zeranol and estradiol induce similar lesions in the testes and epididymides of the prepubertal beef bull.
Fundam Appl Toxicol 1988; 10(1):73-81FA

Abstract

Testes and epididymides of three groups (N = 4) of 6-month-old crossbred beef bulls implanted with a placebo or 150, 300, and 600 mg of estradiol-17 beta at birth, 2, and 4 months of age, respectively, or 36 mg of zeranol at birth only were examined for histologic changes and development. There was a reduction (p less than 0.01) in paired testicular weight and seminiferous tubular diameter (mean +/- SE) of zeranol- and estradiol-implanted bulls compared with control bulls, 29.0 +/- 1.3, 20.6 +/- 1.8 vs 48.1 +/- 5.9 g and 70.9 +/- 0.6, 73.7 +/- 1.2 vs 125.9 +/- 2.0 microns, respectively. The basement membranes of seminiferous tubules (mean +/- SE) were thicker in zeranol-implanted bulls (3.34 +/- 0.07 microns) than those in estradiol-implanted bulls (2.74 +/- 0.06 microns), both of which were thicker than those of control bulls (1.05 +/- 0.03 micron) (p less than 0.01). Supporting cells lining the basement membranes in zeranol- and estradiol-implanted bulls were predominantly undifferentiated whereas most supporting cells had differentiated into Sertoli cells in control bulls. Interstitial cells typical of adult Leydig cells and germinal cells in advanced stages of differentiation were abundant in control bulls, but scarce in both zeranol- and estradiol-implanted bulls. The epididymal epithelium was poorly differentiated, lacked microvilli, and was dysplastic, especially in the cauda epididymidis, in both zeranol- and estradiol-implanted bulls. The epithelium was lower in height (p less than 0.01) in both the caput and cauda epididymidis of treated animals than in that of controls.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

University of Illinois College of Veterinary Medicine, Urbana 61801.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3350231

Citation

Veeramachaneni, D N., et al. "Zeranol and Estradiol Induce Similar Lesions in the Testes and Epididymides of the Prepubertal Beef Bull." Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology, vol. 10, no. 1, 1988, pp. 73-81.
Veeramachaneni DN, Sherman GB, Floyd JG, et al. Zeranol and estradiol induce similar lesions in the testes and epididymides of the prepubertal beef bull. Fundam Appl Toxicol. 1988;10(1):73-81.
Veeramachaneni, D. N., Sherman, G. B., Floyd, J. G., Ott, R. S., & Hixon, J. E. (1988). Zeranol and estradiol induce similar lesions in the testes and epididymides of the prepubertal beef bull. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology, 10(1), pp. 73-81.
Veeramachaneni DN, et al. Zeranol and Estradiol Induce Similar Lesions in the Testes and Epididymides of the Prepubertal Beef Bull. Fundam Appl Toxicol. 1988;10(1):73-81. PubMed PMID: 3350231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Zeranol and estradiol induce similar lesions in the testes and epididymides of the prepubertal beef bull. AU - Veeramachaneni,D N, AU - Sherman,G B, AU - Floyd,J G, AU - Ott,R S, AU - Hixon,J E, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 73 EP - 81 JF - Fundamental and applied toxicology : official journal of the Society of Toxicology JO - Fundam Appl Toxicol VL - 10 IS - 1 N2 - Testes and epididymides of three groups (N = 4) of 6-month-old crossbred beef bulls implanted with a placebo or 150, 300, and 600 mg of estradiol-17 beta at birth, 2, and 4 months of age, respectively, or 36 mg of zeranol at birth only were examined for histologic changes and development. There was a reduction (p less than 0.01) in paired testicular weight and seminiferous tubular diameter (mean +/- SE) of zeranol- and estradiol-implanted bulls compared with control bulls, 29.0 +/- 1.3, 20.6 +/- 1.8 vs 48.1 +/- 5.9 g and 70.9 +/- 0.6, 73.7 +/- 1.2 vs 125.9 +/- 2.0 microns, respectively. The basement membranes of seminiferous tubules (mean +/- SE) were thicker in zeranol-implanted bulls (3.34 +/- 0.07 microns) than those in estradiol-implanted bulls (2.74 +/- 0.06 microns), both of which were thicker than those of control bulls (1.05 +/- 0.03 micron) (p less than 0.01). Supporting cells lining the basement membranes in zeranol- and estradiol-implanted bulls were predominantly undifferentiated whereas most supporting cells had differentiated into Sertoli cells in control bulls. Interstitial cells typical of adult Leydig cells and germinal cells in advanced stages of differentiation were abundant in control bulls, but scarce in both zeranol- and estradiol-implanted bulls. The epididymal epithelium was poorly differentiated, lacked microvilli, and was dysplastic, especially in the cauda epididymidis, in both zeranol- and estradiol-implanted bulls. The epithelium was lower in height (p less than 0.01) in both the caput and cauda epididymidis of treated animals than in that of controls.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0272-0590 UR - https://www.unboundmedicine.com/medline/citation/3350231/Zeranol_and_estradiol_induce_similar_lesions_in_the_testes_and_epididymides_of_the_prepubertal_beef_bull_ L2 - https://medlineplus.gov/testiculardisorders.html DB - PRIME DP - Unbound Medicine ER -