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Necrobiosis lipoidica diabeticorum with cholesterol clefts in the differential diagnosis of necrobiotic xanthogranuloma.
J Cutan Pathol. 1988 Feb; 15(1):18-21.JC

Abstract

The histopathologic findings in 331 cases of necrobiosis lipoidica diabeticorum seen during a 50-year period were reviewed. Three cases showing cholesterol cleft formation were found. All 3 cases were associated with severe diabetes mellitus. The differential diagnosis of importance is necrobiotic xanthogranuloma. Common features included extensive hyaline necrobiosis and foreign-body giant cells. Atypical and Touton-type giant cells are more common in necrobiotic xanthogranuloma. Vascular changes in necrobiotic xanthogranuloma may include granulomatous involvement of muscular walls with thrombosis. Explanations for cholesterol cleft formation are offered. When cholesterol clefts are seen in biopsy specimens of necrobiosis, necrobiotic xanthogranuloma must be ruled out. In addition, when found in necrobiosis lipoidica diabeticorum, these clefts may imply diabetes mellitus with complications.

Authors+Show Affiliations

Department of Dermatology, Mayo Clinic, Rochester, MN 55905.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

3351060

Citation

Gibson, L E., et al. "Necrobiosis Lipoidica Diabeticorum With Cholesterol Clefts in the Differential Diagnosis of Necrobiotic Xanthogranuloma." Journal of Cutaneous Pathology, vol. 15, no. 1, 1988, pp. 18-21.
Gibson LE, Reizner GT, Winkelmann RK. Necrobiosis lipoidica diabeticorum with cholesterol clefts in the differential diagnosis of necrobiotic xanthogranuloma. J Cutan Pathol. 1988;15(1):18-21.
Gibson, L. E., Reizner, G. T., & Winkelmann, R. K. (1988). Necrobiosis lipoidica diabeticorum with cholesterol clefts in the differential diagnosis of necrobiotic xanthogranuloma. Journal of Cutaneous Pathology, 15(1), 18-21.
Gibson LE, Reizner GT, Winkelmann RK. Necrobiosis Lipoidica Diabeticorum With Cholesterol Clefts in the Differential Diagnosis of Necrobiotic Xanthogranuloma. J Cutan Pathol. 1988;15(1):18-21. PubMed PMID: 3351060.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Necrobiosis lipoidica diabeticorum with cholesterol clefts in the differential diagnosis of necrobiotic xanthogranuloma. AU - Gibson,L E, AU - Reizner,G T, AU - Winkelmann,R K, PY - 1988/2/1/pubmed PY - 1988/2/1/medline PY - 1988/2/1/entrez SP - 18 EP - 21 JF - Journal of cutaneous pathology JO - J. Cutan. Pathol. VL - 15 IS - 1 N2 - The histopathologic findings in 331 cases of necrobiosis lipoidica diabeticorum seen during a 50-year period were reviewed. Three cases showing cholesterol cleft formation were found. All 3 cases were associated with severe diabetes mellitus. The differential diagnosis of importance is necrobiotic xanthogranuloma. Common features included extensive hyaline necrobiosis and foreign-body giant cells. Atypical and Touton-type giant cells are more common in necrobiotic xanthogranuloma. Vascular changes in necrobiotic xanthogranuloma may include granulomatous involvement of muscular walls with thrombosis. Explanations for cholesterol cleft formation are offered. When cholesterol clefts are seen in biopsy specimens of necrobiosis, necrobiotic xanthogranuloma must be ruled out. In addition, when found in necrobiosis lipoidica diabeticorum, these clefts may imply diabetes mellitus with complications. SN - 0303-6987 UR - https://www.unboundmedicine.com/medline/citation/3351060/Necrobiosis_lipoidica_diabeticorum_with_cholesterol_clefts_in_the_differential_diagnosis_of_necrobiotic_xanthogranuloma_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0303-6987&date=1988&volume=15&issue=1&spage=18 DB - PRIME DP - Unbound Medicine ER -