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Neurodegenerative Diseases and Flavonoids: Special Reference to Kaempferol.
CNS Neurol Disord Drug Targets. 2021; 20(4):327-342.CN

Abstract

Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, Huntington's disease, Multiple Sclerosis and Ischemic stroke have become a major health problem worldwide. Pre-clinical studies have demonstrated the beneficial effects of flavonoids on neurodegenerative diseases and suggest them to be used as therapeutic agents. Kaempferol is found in many plants such as tea, beans, broccoli, strawberries, and neuroprotective effects against the development of many neurodegenerative diseases such as Parkinson, Alzheimer's disease and Huntington's disease. The present study summarizes the neuroprotective effects of kaempferol in various models of neurodegenerative diseases. Kaempferol delays the initiation as well as the progression of neurodegenerative disorders by acting as a scavenger of free radicals and preserving the activity of various antioxidant enzymes. Kaempferol can cross the Blood-Brain Barrier (BBB), and therefore results in an enhanced protective effect. The multi-target property of kaempferol makes it a potential dietary supplement in preventing and treating neurodegenerative diseases.

Authors+Show Affiliations

Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India.Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33511932

Citation

Rahul, , and Yasir H. Siddique. "Neurodegenerative Diseases and Flavonoids: Special Reference to Kaempferol." CNS & Neurological Disorders Drug Targets, vol. 20, no. 4, 2021, pp. 327-342.
Rahul , Siddique YH. Neurodegenerative Diseases and Flavonoids: Special Reference to Kaempferol. CNS Neurol Disord Drug Targets. 2021;20(4):327-342.
Rahul, ., & Siddique, Y. H. (2021). Neurodegenerative Diseases and Flavonoids: Special Reference to Kaempferol. CNS & Neurological Disorders Drug Targets, 20(4), 327-342. https://doi.org/10.2174/1871527320666210129122033
Rahul , Siddique YH. Neurodegenerative Diseases and Flavonoids: Special Reference to Kaempferol. CNS Neurol Disord Drug Targets. 2021;20(4):327-342. PubMed PMID: 33511932.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurodegenerative Diseases and Flavonoids: Special Reference to Kaempferol. AU - Rahul,, AU - Siddique,Yasir H, PY - 2020/05/19/received PY - 2020/08/21/revised PY - 2020/09/13/accepted PY - 2021/1/30/pubmed PY - 2022/1/12/medline PY - 2021/1/29/entrez KW - Alzheimer's disease. KW - Neurodegenerative diseases KW - Parkinson's disease KW - blood-brain barrier KW - flavonoid KW - kaempferol SP - 327 EP - 342 JF - CNS & neurological disorders drug targets JO - CNS Neurol Disord Drug Targets VL - 20 IS - 4 N2 - Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, Huntington's disease, Multiple Sclerosis and Ischemic stroke have become a major health problem worldwide. Pre-clinical studies have demonstrated the beneficial effects of flavonoids on neurodegenerative diseases and suggest them to be used as therapeutic agents. Kaempferol is found in many plants such as tea, beans, broccoli, strawberries, and neuroprotective effects against the development of many neurodegenerative diseases such as Parkinson, Alzheimer's disease and Huntington's disease. The present study summarizes the neuroprotective effects of kaempferol in various models of neurodegenerative diseases. Kaempferol delays the initiation as well as the progression of neurodegenerative disorders by acting as a scavenger of free radicals and preserving the activity of various antioxidant enzymes. Kaempferol can cross the Blood-Brain Barrier (BBB), and therefore results in an enhanced protective effect. The multi-target property of kaempferol makes it a potential dietary supplement in preventing and treating neurodegenerative diseases. SN - 1996-3181 UR - https://www.unboundmedicine.com/medline/citation/33511932/Neurodegenerative_Diseases_and_Flavonoids:_Special_Reference_to_Kaempferol_ L2 - https://www.eurekaselect.com/190895/article DB - PRIME DP - Unbound Medicine ER -