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Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K, and N501Y variants by BNT162b2 vaccine-elicited sera.
bioRxiv. 2021 Jan 27B

Abstract

We engineered three SARS-CoV-2 viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion+N501Y+D614G from UK; and E484K+N501Y+D614G from SA. Neutralization geometric mean titers (GMTs) of twenty BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, U.S.A.Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, U.S.A.Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston TX, U.S.A. Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, U.S.A.Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, U.S.A.Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, U.S.A.Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, U.S.A.Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, U.S.A.Pfizer, 401 N Middletown Rd., Pearl River, NY 10960, U.S.A.Pfizer, 401 N Middletown Rd., Pearl River, NY 10960, U.S.A.Pfizer, 401 N Middletown Rd., Pearl River, NY 10960, U.S.A.Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston TX, U.S.A. Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, U.S.A.Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston TX, U.S.A. Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, U.S.A.Pfizer, 401 N Middletown Rd., Pearl River, NY 10960, U.S.A.Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, U.S.A. Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, U.S.A. Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX, U.S.A. Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX, U.S.A. Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch, Galveston, TX, U.S.A.

Pub Type(s)

Preprint

Language

eng

PubMed ID

33532771

Citation

Xie, Xuping, et al. "Neutralization of SARS-CoV-2 Spike 69/70 Deletion, E484K, and N501Y Variants By BNT162b2 Vaccine-elicited Sera." BioRxiv : the Preprint Server for Biology, 2021.
Xie X, Liu Y, Liu J, et al. Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K, and N501Y variants by BNT162b2 vaccine-elicited sera. bioRxiv. 2021.
Xie, X., Liu, Y., Liu, J., Zhang, X., Zou, J., Fontes-Garfias, C. R., Xia, H., Swanson, K. A., Cutler, M., Cooper, D., Menachery, V. D., Weaver, S., Dormitzer, P. R., & Shi, P. Y. (2021). Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K, and N501Y variants by BNT162b2 vaccine-elicited sera. BioRxiv : the Preprint Server for Biology. https://doi.org/10.1101/2021.01.27.427998
Xie X, et al. Neutralization of SARS-CoV-2 Spike 69/70 Deletion, E484K, and N501Y Variants By BNT162b2 Vaccine-elicited Sera. bioRxiv. 2021 Jan 27; PubMed PMID: 33532771.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K, and N501Y variants by BNT162b2 vaccine-elicited sera. AU - Xie,Xuping, AU - Liu,Yang, AU - Liu,Jianying, AU - Zhang,Xianwen, AU - Zou,Jing, AU - Fontes-Garfias,Camila R, AU - Xia,Hongjie, AU - Swanson,Kena A, AU - Cutler,Mark, AU - Cooper,David, AU - Menachery,Vineet D, AU - Weaver,Scott, AU - Dormitzer,Philip R, AU - Shi,Pei-Yong, Y1 - 2021/01/27/ PY - 2021/2/3/entrez PY - 2021/2/4/pubmed PY - 2021/2/4/medline JF - bioRxiv : the preprint server for biology JO - bioRxiv N2 - We engineered three SARS-CoV-2 viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion+N501Y+D614G from UK; and E484K+N501Y+D614G from SA. Neutralization geometric mean titers (GMTs) of twenty BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses. UR - https://www.unboundmedicine.com/medline/citation/33532771/Neutralization_of_SARS_CoV_2_spike_69/70_deletion_E484K_and_N501Y_variants_by_BNT162b2_vaccine_elicited_sera_ L2 - https://doi.org/10.1101/2021.01.27.427998 DB - PRIME DP - Unbound Medicine ER -
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