Publisher Full Text
Introduction into the Marseille geographical area of a mild SARS-CoV-2 variant originating from sub-Saharan Africa: An investigational study.Travel Med Infect Dis. 2021 Mar-Apr; 40:101980.TM
Abstract
BACKGROUND
In Marseille, France, the COVID-19 incidence evolved unusually with several successive epidemic phases. The second outbreak started in July, was associated with North Africa, and involved travelers and an outbreak on passenger ships. This suggested the involvement of a new viral variant.
METHODS
We sequenced the genomes from 916 SARS-CoV-2 strains from COVID-19 patients in our institute. The patients' demographic and clinical features were compared according to the infecting viral variant.
RESULTS
From June 26th to August 14th, we identified a new viral variant (Marseille-1). Based on genome sequences (n = 89) or specific qPCR (n = 53), 142 patients infected with this variant were detected. It is characterized by a combination of 10 mutations located in the nsp2, nsp3, nsp12, S, ORF3a, ORF8 and N/ORF14 genes. We identified Senegal and Gambia, where the virus had been transferred from China and Europe in February-April as the sources of the Marseille-1 variant, which then most likely reached Marseille through Maghreb when French borders reopened. In France, this variant apparently remained almost limited to Marseille. In addition, it was significantly associated with a milder disease compared to clade 20A ancestor strains, in univariate analysis.
CONCLUSION
Our results demonstrate that SARS-CoV-2 can genetically diversify rapidly, its variants can diffuse internationally and cause successive outbreaks.
Links
MeSH
Pub Type(s)
Journal Article
Language
eng
PubMed ID
33535105
Citation
Colson, Philippe, et al. "Introduction Into the Marseille Geographical Area of a Mild SARS-CoV-2 Variant Originating From sub-Saharan Africa: an Investigational Study." Travel Medicine and Infectious Disease, vol. 40, 2021, p. 101980.
Colson P, Levasseur A, Gautret P, et al. Introduction into the Marseille geographical area of a mild SARS-CoV-2 variant originating from sub-Saharan Africa: An investigational study. Travel Med Infect Dis. 2021;40:101980.
Colson, P., Levasseur, A., Gautret, P., Fenollar, F., Thuan Hoang, V., Delerce, J., Bitam, I., Saile, R., Maaloum, M., Padane, A., Bedotto, M., Brechard, L., Bossi, V., Ben Khedher, M., Chaudet, H., Million, M., Tissot-Dupont, H., Lagier, J. C., Mboup, S., ... Raoult, D. (2021). Introduction into the Marseille geographical area of a mild SARS-CoV-2 variant originating from sub-Saharan Africa: An investigational study. Travel Medicine and Infectious Disease, 40, 101980. https://doi.org/10.1016/j.tmaid.2021.101980
Colson P, et al. Introduction Into the Marseille Geographical Area of a Mild SARS-CoV-2 Variant Originating From sub-Saharan Africa: an Investigational Study. Travel Med Infect Dis. 2021 Mar-Apr;40:101980. PubMed PMID: 33535105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Introduction into the Marseille geographical area of a mild SARS-CoV-2 variant originating from sub-Saharan Africa: An investigational study.
AU - Colson,Philippe,
AU - Levasseur,Anthony,
AU - Gautret,Philippe,
AU - Fenollar,Florence,
AU - Thuan Hoang,Van,
AU - Delerce,Jeremy,
AU - Bitam,Idir,
AU - Saile,Rachid,
AU - Maaloum,Mossaab,
AU - Padane,Abdou,
AU - Bedotto,Marielle,
AU - Brechard,Ludivine,
AU - Bossi,Vincent,
AU - Ben Khedher,Mariem,
AU - Chaudet,Hervé,
AU - Million,Matthieu,
AU - Tissot-Dupont,Hervé,
AU - Lagier,Jean-Christophe,
AU - Mboup,Souleymane,
AU - Fournier,Pierre-Edouard,
AU - Raoult,Didier,
Y1 - 2021/01/31/
PY - 2020/12/22/received
PY - 2021/01/20/revised
PY - 2021/01/21/accepted
PY - 2021/2/4/pubmed
PY - 2021/4/28/medline
PY - 2021/2/3/entrez
KW - Covid-19
KW - Genome
KW - Marseille-1
KW - SARS-CoV-2
KW - Travel
KW - Variant
SP - 101980
EP - 101980
JF - Travel medicine and infectious disease
JO - Travel Med Infect Dis
VL - 40
N2 - BACKGROUND: In Marseille, France, the COVID-19 incidence evolved unusually with several successive epidemic phases. The second outbreak started in July, was associated with North Africa, and involved travelers and an outbreak on passenger ships. This suggested the involvement of a new viral variant. METHODS: We sequenced the genomes from 916 SARS-CoV-2 strains from COVID-19 patients in our institute. The patients' demographic and clinical features were compared according to the infecting viral variant. RESULTS: From June 26th to August 14th, we identified a new viral variant (Marseille-1). Based on genome sequences (n = 89) or specific qPCR (n = 53), 142 patients infected with this variant were detected. It is characterized by a combination of 10 mutations located in the nsp2, nsp3, nsp12, S, ORF3a, ORF8 and N/ORF14 genes. We identified Senegal and Gambia, where the virus had been transferred from China and Europe in February-April as the sources of the Marseille-1 variant, which then most likely reached Marseille through Maghreb when French borders reopened. In France, this variant apparently remained almost limited to Marseille. In addition, it was significantly associated with a milder disease compared to clade 20A ancestor strains, in univariate analysis. CONCLUSION: Our results demonstrate that SARS-CoV-2 can genetically diversify rapidly, its variants can diffuse internationally and cause successive outbreaks.
SN - 1873-0442
UR - https://www.unboundmedicine.com/medline/citation/33535105/Introduction_into_the_Marseille_geographical_area_of_a_mild_SARS_CoV_2_variant_originating_from_sub_Saharan_Africa:_An_investigational_study_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S1477-8939(21)00021-1
DB - PRIME
DP - Unbound Medicine
ER -
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