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Infection and disease spectrum in individuals with household exposure to SARS-CoV-2: A family cluster cohort study.
J Med Virol. 2021 May; 93(5):3033-3046.JM

Abstract

We primarily quantified exposure patterns, transmission characteristics, and the clinical spectrum of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among household contacts of individuals with severe coronavirus disease-2019 (COVID-19). We conducted a retrospective cohort study of 20 index patients hospitalized with severe COVID-19 and 79 of their household contacts. We determined the transmission frequency, range of manifestations of SARS-CoV-2 infection, and factors associated with infection in household settings. Of the 79 household contacts, 53 (67%) developed SARS-CoV-2 infection (49 [62%] symptomatic, 4 [5%] asymptomatic). Eight patients (10%) developed severe COVID-19, and one died of COVID-19 pneumonia (case-fatality rate: 1.9%). The probability of SARS-CoV-2 infection was similar in children and adults (55% vs. 72%, p = .14), with children being less likely to develop the symptomatic disease (46% vs. 68%, p = .06). Handwashing ≥ 5 times/day was associated with reduced infection risk (52.8% vs. 76.9%, p = .04). SARS-CoV-2 has a high frequency of transmission among household contacts. Nonhospitalized individuals with SARS-CoV-2 infection should be quarantined in patient care facilities rather than at home to minimize spread, if possible, and frequent handwashing should be practiced to prevent transmission.

Authors+Show Affiliations

Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33538342

Citation

Xie, Wen, et al. "Infection and Disease Spectrum in Individuals With Household Exposure to SARS-CoV-2: a Family Cluster Cohort Study." Journal of Medical Virology, vol. 93, no. 5, 2021, pp. 3033-3046.
Xie W, Chen Z, Wang Q, et al. Infection and disease spectrum in individuals with household exposure to SARS-CoV-2: A family cluster cohort study. J Med Virol. 2021;93(5):3033-3046.
Xie, W., Chen, Z., Wang, Q., Song, M., Cao, Y., Wang, L., & Pan, C. Q. (2021). Infection and disease spectrum in individuals with household exposure to SARS-CoV-2: A family cluster cohort study. Journal of Medical Virology, 93(5), 3033-3046. https://doi.org/10.1002/jmv.26847
Xie W, et al. Infection and Disease Spectrum in Individuals With Household Exposure to SARS-CoV-2: a Family Cluster Cohort Study. J Med Virol. 2021;93(5):3033-3046. PubMed PMID: 33538342.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Infection and disease spectrum in individuals with household exposure to SARS-CoV-2: A family cluster cohort study. AU - Xie,Wen, AU - Chen,Zhihai, AU - Wang,Qi, AU - Song,Meihua, AU - Cao,Ying, AU - Wang,Lin, AU - Pan,Calvin Q, Y1 - 2021/02/12/ PY - 2021/01/27/revised PY - 2020/10/29/received PY - 2021/01/28/accepted PY - 2021/2/5/pubmed PY - 2021/4/22/medline PY - 2021/2/4/entrez KW - COVID-19 KW - SARS-CoV-2 KW - coronavirus disease 2019 KW - handwashing KW - infectious disease transmission KW - quarantine KW - severe acute respiratory syndrome coronavirus 2 SP - 3033 EP - 3046 JF - Journal of medical virology JO - J Med Virol VL - 93 IS - 5 N2 - We primarily quantified exposure patterns, transmission characteristics, and the clinical spectrum of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among household contacts of individuals with severe coronavirus disease-2019 (COVID-19). We conducted a retrospective cohort study of 20 index patients hospitalized with severe COVID-19 and 79 of their household contacts. We determined the transmission frequency, range of manifestations of SARS-CoV-2 infection, and factors associated with infection in household settings. Of the 79 household contacts, 53 (67%) developed SARS-CoV-2 infection (49 [62%] symptomatic, 4 [5%] asymptomatic). Eight patients (10%) developed severe COVID-19, and one died of COVID-19 pneumonia (case-fatality rate: 1.9%). The probability of SARS-CoV-2 infection was similar in children and adults (55% vs. 72%, p = .14), with children being less likely to develop the symptomatic disease (46% vs. 68%, p = .06). Handwashing ≥ 5 times/day was associated with reduced infection risk (52.8% vs. 76.9%, p = .04). SARS-CoV-2 has a high frequency of transmission among household contacts. Nonhospitalized individuals with SARS-CoV-2 infection should be quarantined in patient care facilities rather than at home to minimize spread, if possible, and frequent handwashing should be practiced to prevent transmission. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/33538342/Infection_and_disease_spectrum_in_individuals_with_household_exposure_to_SARS_CoV_2:_A_family_cluster_cohort_study_ L2 - https://doi.org/10.1002/jmv.26847 DB - PRIME DP - Unbound Medicine ER -