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Isolated splenic abscess due to melioidosis in type 1 diabetes mellitus: laboratory diagnosis of Burkholderia pseudomallei in resource-restricted setting.
BMJ Case Rep. 2021 Feb 04; 14(2)BC

Abstract

Diabetes mellitus, type 1 in particular, is a well-recognised risk factor for melioidosis, a disease caused by Burkholderia pseudomallei Melioidosis is endemic in Southeast Asia and in northern Australia and has a variety of clinical presentation, isolated splenic abscess being one of them. B. pseudomallei, however, is an uncommon aetiology of splenic abscess. The diagnosis of melioidosis is often overlooked unless the clinician and the microbiologist are suspicious of the condition. Multiple splenic abscesses and perisplenic collection were noted in CT scan of the abdomen in a patient of type 1 diabetes, presenting with fever for preceding 4 weeks. B. pseudomallei was isolated from the splenic aspirate and the diagnosis was made based on gram stain and routine biochemical tests. He was successfully treated with antibiotics. We postulate that the likely route of infection was inoculation through skin, the integrity of which was compromised by multiple subcutaneous insulin injections.

Authors+Show Affiliations

Medicine, Midnapore Medical College and Hospital, Midnapore, West Bengal, India.Medicine, Midnapore Medical College and Hospital, Midnapore, West Bengal, India.Microbiology, Medical College and Hospital Kolkata, Kolkata, West Bengal, India.Endocrinology and Metabolism, Medical College and Hospital Kolkata, Kolkata, West Bengal, India docparthapc@yahoo.co.in.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

33541991

Citation

Gupta, Abhishek Prakash, et al. "Isolated Splenic Abscess Due to Melioidosis in Type 1 Diabetes Mellitus: Laboratory Diagnosis of Burkholderia Pseudomallei in Resource-restricted Setting." BMJ Case Reports, vol. 14, no. 2, 2021.
Gupta AP, Halder R, Chakraborty M, et al. Isolated splenic abscess due to melioidosis in type 1 diabetes mellitus: laboratory diagnosis of Burkholderia pseudomallei in resource-restricted setting. BMJ Case Rep. 2021;14(2).
Gupta, A. P., Halder, R., Chakraborty, M., & Chakraborty, P. P. (2021). Isolated splenic abscess due to melioidosis in type 1 diabetes mellitus: laboratory diagnosis of Burkholderia pseudomallei in resource-restricted setting. BMJ Case Reports, 14(2). https://doi.org/10.1136/bcr-2020-238985
Gupta AP, et al. Isolated Splenic Abscess Due to Melioidosis in Type 1 Diabetes Mellitus: Laboratory Diagnosis of Burkholderia Pseudomallei in Resource-restricted Setting. BMJ Case Rep. 2021 Feb 4;14(2) PubMed PMID: 33541991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isolated splenic abscess due to melioidosis in type 1 diabetes mellitus: laboratory diagnosis of Burkholderia pseudomallei in resource-restricted setting. AU - Gupta,Abhishek Prakash, AU - Halder,Ratan, AU - Chakraborty,Mandira, AU - Chakraborty,Partha Pratim, Y1 - 2021/02/04/ PY - 2023/02/04/pmc-release PY - 2021/2/5/entrez PY - 2021/2/6/pubmed PY - 2021/3/6/medline KW - diabetes KW - tropical medicine (infectious disease) JF - BMJ case reports JO - BMJ Case Rep VL - 14 IS - 2 N2 - Diabetes mellitus, type 1 in particular, is a well-recognised risk factor for melioidosis, a disease caused by Burkholderia pseudomallei Melioidosis is endemic in Southeast Asia and in northern Australia and has a variety of clinical presentation, isolated splenic abscess being one of them. B. pseudomallei, however, is an uncommon aetiology of splenic abscess. The diagnosis of melioidosis is often overlooked unless the clinician and the microbiologist are suspicious of the condition. Multiple splenic abscesses and perisplenic collection were noted in CT scan of the abdomen in a patient of type 1 diabetes, presenting with fever for preceding 4 weeks. B. pseudomallei was isolated from the splenic aspirate and the diagnosis was made based on gram stain and routine biochemical tests. He was successfully treated with antibiotics. We postulate that the likely route of infection was inoculation through skin, the integrity of which was compromised by multiple subcutaneous insulin injections. SN - 1757-790X UR - https://www.unboundmedicine.com/medline/citation/33541991/Isolated_splenic_abscess_due_to_melioidosis_in_type_1_diabetes_mellitus:_laboratory_diagnosis_of_Burkholderia_pseudomallei_in_resource_restricted_setting_ L2 - https://casereports.bmj.com/lookup/pmidlookup?view=long&pmid=33541991 DB - PRIME DP - Unbound Medicine ER -