Tags

Type your tag names separated by a space and hit enter

Mechanistic new insights of flavonols on neurodegenerative diseases.
Biomed Pharmacother. 2021 May; 137:111253.BP

Abstract

With a large and increasing elderly population, neurodegenerative diseases such as Parkinson's disease (PD), Huntington disease (HD), Alzheimer's disease (AD), Amyotrophic lateral sclerosis (ALS) and Multiple sclerosis (MS) have become a major and growing health problem. During the past few decades, the elderly population has grown 2.5 % every year. Unfortunately, there are no specific therapeutic remedies available to slow the onset or development of these diseases. An aging brain causes many pathophysiological changes and is the major risk factor for most of the neurodegenerative disorders. Polyphenolic compounds such as flavonols have shown therapeutic potential and can contribute to the treatment of these diseases. In this review, evidence for the beneficial neuroprotective effect of multiple flavonols is discussed and their multifactorial cellular pathways for the progressions of age-associated brain changes are identified. Moreover, the animal models of these diseases support the neuroprotective effect and target the potential of flavonols in the treatment of neurodegenerative diseases.

Authors+Show Affiliations

The Key Laboratory of High-Altitude Medical Application of Qinghai Province, Qinghai, Xining, 810001, China; Department of Basic Medicine, Medical College of Qinghai University, Qinghai, Xining, 810001, China.The Key Laboratory of High-Altitude Medical Application of Qinghai Province, Qinghai, Xining, 810001, China; Department of Basic Medicine, Medical College of Qinghai University, Qinghai, Xining, 810001, China.Department of Basic Medicine, Medical College of Qinghai University, Qinghai, Xining, 810001, China.Department of Pharmacology, Fatima Memorial College of Medicine and Dentistry, Punjab Lahore, 54000, Pakistan.Department of Emergency Medicine, Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes, MK6 5BY, United Kingdom.Department of Basic Medicine, Medical College of Qinghai University, Qinghai, Xining, 810001, China.The Key Laboratory of High-Altitude Medical Application of Qinghai Province, Qinghai, Xining, 810001, China.The Key Laboratory of High-Altitude Medical Application of Qinghai Province, Qinghai, Xining, 810001, China.Department of Basic Medicine, Medical College of Qinghai University, Qinghai, Xining, 810001, China.Department of Basic Medicine, Medical College of Qinghai University, Qinghai, Xining, 810001, China.Department of Hepatobiliary Surgery, Qinghai University Affiliated Hospital, Qinghai, Xining, 810001, China.Department of Crop Genetics and Breeding, Qinghai Academy of Agricultural and Forestry Sciences, Qinghai University, Xining, 810016, China.Department of Hepatobiliary Surgery, Qinghai University Affiliated Hospital, Qinghai, Xining, 810001, China.The Key Laboratory of High-Altitude Medical Application of Qinghai Province, Qinghai, Xining, 810001, China; Department of Basic Medicine, Medical College of Qinghai University, Qinghai, Xining, 810001, China. Electronic address: zw0228@qhu.edu.cn.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33545661

Citation

Tahir, Muhammad Shoaib, et al. "Mechanistic New Insights of Flavonols On Neurodegenerative Diseases." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 137, 2021, p. 111253.
Tahir MS, Almezgagi M, Zhang Y, et al. Mechanistic new insights of flavonols on neurodegenerative diseases. Biomed Pharmacother. 2021;137:111253.
Tahir, M. S., Almezgagi, M., Zhang, Y., Bashir, A., Abdullah, H. M., Gamah, M., Wang, X., Zhu, Q., Shen, X., Ma, Q., Ali, M., Solangi, Z. A., Malik, W. S., & Zhang, W. (2021). Mechanistic new insights of flavonols on neurodegenerative diseases. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 137, 111253. https://doi.org/10.1016/j.biopha.2021.111253
Tahir MS, et al. Mechanistic New Insights of Flavonols On Neurodegenerative Diseases. Biomed Pharmacother. 2021;137:111253. PubMed PMID: 33545661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanistic new insights of flavonols on neurodegenerative diseases. AU - Tahir,Muhammad Shoaib, AU - Almezgagi,Maged, AU - Zhang,Yu, AU - Bashir,Adnan, AU - Abdullah,Hasnat Mazhar, AU - Gamah,Mohammed, AU - Wang,Xiaozhou, AU - Zhu,Qinfang, AU - Shen,Xiangqun, AU - Ma,Qianqian, AU - Ali,Muhammad, AU - Solangi,Zeeshan Ahmed, AU - Malik,Waseem Sami, AU - Zhang,Wei, Y1 - 2021/02/02/ PY - 2020/09/28/received PY - 2020/12/22/revised PY - 2021/01/03/accepted PY - 2021/2/6/pubmed PY - 2021/7/20/medline PY - 2021/2/5/entrez KW - Flavonols KW - Neurodegenerative disease KW - Neuroinflammation KW - Neuroprotective SP - 111253 EP - 111253 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 137 N2 - With a large and increasing elderly population, neurodegenerative diseases such as Parkinson's disease (PD), Huntington disease (HD), Alzheimer's disease (AD), Amyotrophic lateral sclerosis (ALS) and Multiple sclerosis (MS) have become a major and growing health problem. During the past few decades, the elderly population has grown 2.5 % every year. Unfortunately, there are no specific therapeutic remedies available to slow the onset or development of these diseases. An aging brain causes many pathophysiological changes and is the major risk factor for most of the neurodegenerative disorders. Polyphenolic compounds such as flavonols have shown therapeutic potential and can contribute to the treatment of these diseases. In this review, evidence for the beneficial neuroprotective effect of multiple flavonols is discussed and their multifactorial cellular pathways for the progressions of age-associated brain changes are identified. Moreover, the animal models of these diseases support the neuroprotective effect and target the potential of flavonols in the treatment of neurodegenerative diseases. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/33545661/Mechanistic_new_insights_of_flavonols_on_neurodegenerative_diseases_ DB - PRIME DP - Unbound Medicine ER -