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Vitamin D improves levels of hormonal, oxidative stress and inflammatory parameters in polycystic ovary syndrome: a meta-analysis study.
Ann Palliat Med. 2021 Jan; 10(1):169-183.AP

Abstract

BACKGROUND

Hyperandrogenism (HA), inflammation, and oxidative damage play key roles in the pathophysiology of polycystic ovary syndrome (PCOS). Whether vitamin D adjuvant therapy improves hormonal, inflammation, and oxidative damage in PCOS patients has aroused widespread interest, but the results are controversial. To evaluate the effect of vitamin D supplementation on hormonal, oxidative stress, and inflammatory parameters in patients with PCOS.

METHODS

A literature search was conducted in Medline, the Cochrane Library, EMBASE, and Web of Science for studies related to PCOS and vitamin D supplementation. All reports of randomized controlled trials (RCTs) published before December 2019 were identified. The fixed-effects model or random-effects model was used to calculate pooled estimates of standardized differences in means (SMD) with 95% confidence intervals (CI).

RESULTS

A total of 956 identified studies were retrieved, and eighteen RCTs involving 1,060 participants were ultimately included in the current meta-analysis. The pooled results demonstrated that vitamin D supplementation in patients with PCOS resulted in a significant improvement in serum total testosterone (TT), high sensitivity C-reactive protein (hs-CRP), total antioxidant capacity (TAC), and malondialdehyde (MDA). No significant effect on free testosterone (FT), dehydroepiandrosterone sulfate (DHEA-S), sex hormone-binding globulin (SHBG), free androgen index (FAI), nitric oxide (NO), and total glutathione (GSH) levels was found. Subgroup analysis showed that vitamin D supplementation reduced hs-CRP and MDA irrespective of the treatment course, type of vitamin D intervention, supplementation frequency, and dosage. Twelve weeks of vitamin D supplementation improved TT and TAC while low-dose vitamin D supplementation (≤1,000 IU/day) improved TT and DHEA-S. Vitamin D co-supplementation reduced TT, FT, and DHEA-S, while a daily supplementation regime improved TT, DHEA-S, and TAC in patients with PCOS.

CONCLUSIONS

The current meta-analysis demonstrates that vitamin D supplementation in patients with PCOS resulted in an improvement in the levels of TT, hs-CRP, TAC, and MDA, but did not affect FT, DHEA-S, SHBG, FAI, NO, and GSH levels. Vitamin D co-supplementation, low-dose vitamin D supplementation (≤1,000 IU/day), and daily supplementation frequency appeared to be more conducive to improving hormones, inflammation, and oxidative stress in PCOS patients.

Authors+Show Affiliations

Basic Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.Basic Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.Basic Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, China. Email: zhangqi@cdutcm.edu.cn.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

33545754

Citation

Zhao, Jun-Feng, et al. "Vitamin D Improves Levels of Hormonal, Oxidative Stress and Inflammatory Parameters in Polycystic Ovary Syndrome: a Meta-analysis Study." Annals of Palliative Medicine, vol. 10, no. 1, 2021, pp. 169-183.
Zhao JF, Li BX, Zhang Q. Vitamin D improves levels of hormonal, oxidative stress and inflammatory parameters in polycystic ovary syndrome: a meta-analysis study. Ann Palliat Med. 2021;10(1):169-183.
Zhao, J. F., Li, B. X., & Zhang, Q. (2021). Vitamin D improves levels of hormonal, oxidative stress and inflammatory parameters in polycystic ovary syndrome: a meta-analysis study. Annals of Palliative Medicine, 10(1), 169-183. https://doi.org/10.21037/apm-20-2201
Zhao JF, Li BX, Zhang Q. Vitamin D Improves Levels of Hormonal, Oxidative Stress and Inflammatory Parameters in Polycystic Ovary Syndrome: a Meta-analysis Study. Ann Palliat Med. 2021;10(1):169-183. PubMed PMID: 33545754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D improves levels of hormonal, oxidative stress and inflammatory parameters in polycystic ovary syndrome: a meta-analysis study. AU - Zhao,Jun-Feng, AU - Li,Bai-Xue, AU - Zhang,Qi, PY - 2020/9/20/received PY - 2021/1/11/accepted PY - 2021/2/6/entrez PY - 2021/2/7/pubmed PY - 2021/5/12/medline KW - Vitamin D KW - hormonal KW - inflammation KW - meta-analysis KW - oxidative stress KW - polycystic ovary syndrome (PCOS) SP - 169 EP - 183 JF - Annals of palliative medicine JO - Ann Palliat Med VL - 10 IS - 1 N2 - BACKGROUND: Hyperandrogenism (HA), inflammation, and oxidative damage play key roles in the pathophysiology of polycystic ovary syndrome (PCOS). Whether vitamin D adjuvant therapy improves hormonal, inflammation, and oxidative damage in PCOS patients has aroused widespread interest, but the results are controversial. To evaluate the effect of vitamin D supplementation on hormonal, oxidative stress, and inflammatory parameters in patients with PCOS. METHODS: A literature search was conducted in Medline, the Cochrane Library, EMBASE, and Web of Science for studies related to PCOS and vitamin D supplementation. All reports of randomized controlled trials (RCTs) published before December 2019 were identified. The fixed-effects model or random-effects model was used to calculate pooled estimates of standardized differences in means (SMD) with 95% confidence intervals (CI). RESULTS: A total of 956 identified studies were retrieved, and eighteen RCTs involving 1,060 participants were ultimately included in the current meta-analysis. The pooled results demonstrated that vitamin D supplementation in patients with PCOS resulted in a significant improvement in serum total testosterone (TT), high sensitivity C-reactive protein (hs-CRP), total antioxidant capacity (TAC), and malondialdehyde (MDA). No significant effect on free testosterone (FT), dehydroepiandrosterone sulfate (DHEA-S), sex hormone-binding globulin (SHBG), free androgen index (FAI), nitric oxide (NO), and total glutathione (GSH) levels was found. Subgroup analysis showed that vitamin D supplementation reduced hs-CRP and MDA irrespective of the treatment course, type of vitamin D intervention, supplementation frequency, and dosage. Twelve weeks of vitamin D supplementation improved TT and TAC while low-dose vitamin D supplementation (≤1,000 IU/day) improved TT and DHEA-S. Vitamin D co-supplementation reduced TT, FT, and DHEA-S, while a daily supplementation regime improved TT, DHEA-S, and TAC in patients with PCOS. CONCLUSIONS: The current meta-analysis demonstrates that vitamin D supplementation in patients with PCOS resulted in an improvement in the levels of TT, hs-CRP, TAC, and MDA, but did not affect FT, DHEA-S, SHBG, FAI, NO, and GSH levels. Vitamin D co-supplementation, low-dose vitamin D supplementation (≤1,000 IU/day), and daily supplementation frequency appeared to be more conducive to improving hormones, inflammation, and oxidative stress in PCOS patients. SN - 2224-5839 UR - https://www.unboundmedicine.com/medline/citation/33545754/Vitamin_D_improves_levels_of_hormonal_oxidative_stress_and_inflammatory_parameters_in_polycystic_ovary_syndrome:_a_meta_analysis_study_ DB - PRIME DP - Unbound Medicine ER -