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Optical coherence tomography angiography in preterm-born children with retinopathy of prematurity.
Graefes Arch Clin Exp Ophthalmol. 2021 Aug; 259(8):2131-2137.GA

Abstract

PURPOSE

To describe the foveal avascular zone (FAZ) and vessel density (VD) in the superficial and deep capillary plexus in children with a history of prematurity on optical coherence tomography angiography (OCTA) and their correlation with gestational age (GA) and birth weight (BW).

METHODS

We enrolled 81 preterm- and eight term-born children in this prospective observational study. The Optovue RTVue AVANTI (Optovue Inc., Fremont, CA) was used to procure the OCTA images. The 3 × 3 mm scan protocol centered on the fovea and the central 1 mm of the grid along with the FAZ of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) was acquired.

RESULTS

The mean SCP-VD was comparable between the preterms and term controls (p = 0.315) in the central fovea (1-mm grid). However, the SCP-VD of the 3-mm grid was lower in the preterms born without ROP, with type 1 ROP, and with type 2 ROP (47.61, 47.90, and 48.82 respectively) compared to that in the term group (51.38; p = 0.031). The FAZ in the SCP (p = 0.003) and DCP (p = 0.003) was significantly smaller in the preterms compared to that in the controls. Based on the GA sub-analysis, the FAZ was significantly smaller in the SCP and DCP of preterms born < 31 weeks and > 31 weeks GA (p < 0.000, p < 0.035, respectively). Based on the BW, the difference between the FAZ in the SCP (p = 0.002) and DCP (p = 0.003) was significant. There was no association between the visual acuity and FAZ.

CONCLUSION

Optical coherence tomography angiography findings in this study show an altered foveal morphology and vascularity in preterms with and without ROP.

Authors+Show Affiliations

Department of Pediatric Retina, Narayana Nethralaya Eye Institute, Bangalore, Karnataka, India. anandvinekar@yahoo.com.Department of Pediatric Retina, Narayana Nethralaya Eye Institute, Bangalore, Karnataka, India. Department of Ophthalmology, Regional Institute of Ophthalmology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.Department of Pediatric Retina, Narayana Nethralaya Eye Institute, Bangalore, Karnataka, India. Department of Ophthalmology, Duke University School of Medicine, Durham, NC, USA.Department of Pediatric Retina, Narayana Nethralaya Eye Institute, Bangalore, Karnataka, India.Department of Pediatric Retina, Narayana Nethralaya Eye Institute, Bangalore, Karnataka, India.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

33547964

Citation

Vinekar, Anand, et al. "Optical Coherence Tomography Angiography in Preterm-born Children With Retinopathy of Prematurity." Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, vol. 259, no. 8, 2021, pp. 2131-2137.
Vinekar A, Sinha S, Mangalesh S, et al. Optical coherence tomography angiography in preterm-born children with retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol. 2021;259(8):2131-2137.
Vinekar, A., Sinha, S., Mangalesh, S., Jayadev, C., & Shetty, B. (2021). Optical coherence tomography angiography in preterm-born children with retinopathy of prematurity. Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 259(8), 2131-2137. https://doi.org/10.1007/s00417-021-05090-7
Vinekar A, et al. Optical Coherence Tomography Angiography in Preterm-born Children With Retinopathy of Prematurity. Graefes Arch Clin Exp Ophthalmol. 2021;259(8):2131-2137. PubMed PMID: 33547964.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optical coherence tomography angiography in preterm-born children with retinopathy of prematurity. AU - Vinekar,Anand, AU - Sinha,Shivani, AU - Mangalesh,Shwetha, AU - Jayadev,Chaitra, AU - Shetty,Bhujang, Y1 - 2021/02/06/ PY - 2020/10/17/received PY - 2021/01/20/accepted PY - 2021/01/18/revised PY - 2021/2/7/pubmed PY - 2021/8/19/medline PY - 2021/2/6/entrez KW - Deep capillary plexus KW - Foveal avascular zone KW - Optical coherence tomography angiography KW - Retinopathy of prematurity KW - Superficial capillary plexus SP - 2131 EP - 2137 JF - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie JO - Graefes Arch Clin Exp Ophthalmol VL - 259 IS - 8 N2 - PURPOSE: To describe the foveal avascular zone (FAZ) and vessel density (VD) in the superficial and deep capillary plexus in children with a history of prematurity on optical coherence tomography angiography (OCTA) and their correlation with gestational age (GA) and birth weight (BW). METHODS: We enrolled 81 preterm- and eight term-born children in this prospective observational study. The Optovue RTVue AVANTI (Optovue Inc., Fremont, CA) was used to procure the OCTA images. The 3 × 3 mm scan protocol centered on the fovea and the central 1 mm of the grid along with the FAZ of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) was acquired. RESULTS: The mean SCP-VD was comparable between the preterms and term controls (p = 0.315) in the central fovea (1-mm grid). However, the SCP-VD of the 3-mm grid was lower in the preterms born without ROP, with type 1 ROP, and with type 2 ROP (47.61, 47.90, and 48.82 respectively) compared to that in the term group (51.38; p = 0.031). The FAZ in the SCP (p = 0.003) and DCP (p = 0.003) was significantly smaller in the preterms compared to that in the controls. Based on the GA sub-analysis, the FAZ was significantly smaller in the SCP and DCP of preterms born < 31 weeks and > 31 weeks GA (p < 0.000, p < 0.035, respectively). Based on the BW, the difference between the FAZ in the SCP (p = 0.002) and DCP (p = 0.003) was significant. There was no association between the visual acuity and FAZ. CONCLUSION: Optical coherence tomography angiography findings in this study show an altered foveal morphology and vascularity in preterms with and without ROP. SN - 1435-702X UR - https://www.unboundmedicine.com/medline/citation/33547964/Optical_coherence_tomography_angiography_in_preterm_born_children_with_retinopathy_of_prematurity_ L2 - https://dx.doi.org/10.1007/s00417-021-05090-7 DB - PRIME DP - Unbound Medicine ER -