Tags

Type your tag names separated by a space and hit enter

The use of mesenchymal stem cells in the process of treatment and tissue regeneration after recovery in patients with Covid-19.
Gene. 2021 Apr 20; 777:145471.GENE

Abstract

In addition to causing health concerns, the new coronavirus has been considered in the world with its unknown mechanism of physiopathogenesis and long-term effects after patient recovery. Pulmonary, renal, hepatic and cardiac complications have been reported so far. Beside the researchers' focus on finding vaccines and using conventional therapies, cell-based therapy might be an effective therapeutic strategy. The use of mesenchymal stem cells (MSCs) is one of the options due to their immunomodulatory properties and their proven effects in the treatment of many diseases. As MSCs are not infected with covid-19, there is evidence that it modulates the immune system and prevents the virus from clotting. Despite the beginning of numerous clinical trials in the use of mesenchymal stem cells, it is necessary to set a practical guideline that specifies items such as cell origin, number of cells, frequency of injection, injection site, etc.

Authors+Show Affiliations

Medical Genetics and Molecular Medicine Department, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran.Immunogenetics Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Amol Faculty of Paramedical Sciences, Mazandaran University of Medical Sciences, Sari, Iran.Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.Department of Medical Biotechnology, Faculty of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran.Immunogenetics Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran; Department of Medical Biotechnology, Faculty of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address: ehsan.enderami@strc.ac.ir.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33549712

Citation

Saburi, Ehsan, et al. "The Use of Mesenchymal Stem Cells in the Process of Treatment and Tissue Regeneration After Recovery in Patients With Covid-19." Gene, vol. 777, 2021, p. 145471.
Saburi E, Abazari MF, Hassannia H, et al. The use of mesenchymal stem cells in the process of treatment and tissue regeneration after recovery in patients with Covid-19. Gene. 2021;777:145471.
Saburi, E., Abazari, M. F., Hassannia, H., Mansour, R. N., Eshaghi-Gorji, R., Gheibi, M., Rahmati, M., & Enderami, S. E. (2021). The use of mesenchymal stem cells in the process of treatment and tissue regeneration after recovery in patients with Covid-19. Gene, 777, 145471. https://doi.org/10.1016/j.gene.2021.145471
Saburi E, et al. The Use of Mesenchymal Stem Cells in the Process of Treatment and Tissue Regeneration After Recovery in Patients With Covid-19. Gene. 2021 Apr 20;777:145471. PubMed PMID: 33549712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The use of mesenchymal stem cells in the process of treatment and tissue regeneration after recovery in patients with Covid-19. AU - Saburi,Ehsan, AU - Abazari,Mohammad Foad, AU - Hassannia,Hadi, AU - Mansour,Reyhaneh Nassiri, AU - Eshaghi-Gorji,Reza, AU - Gheibi,Mobina, AU - Rahmati,Mohammad, AU - Enderami,Seyed Ehsan, Y1 - 2021/02/04/ PY - 2020/10/08/received PY - 2020/12/24/revised PY - 2021/01/28/accepted PY - 2021/2/8/pubmed PY - 2021/3/9/medline PY - 2021/2/7/entrez KW - Covid 19 KW - Mesenchymal stem cells KW - Tissue regeneration KW - Treatment SP - 145471 EP - 145471 JF - Gene JO - Gene VL - 777 N2 - In addition to causing health concerns, the new coronavirus has been considered in the world with its unknown mechanism of physiopathogenesis and long-term effects after patient recovery. Pulmonary, renal, hepatic and cardiac complications have been reported so far. Beside the researchers' focus on finding vaccines and using conventional therapies, cell-based therapy might be an effective therapeutic strategy. The use of mesenchymal stem cells (MSCs) is one of the options due to their immunomodulatory properties and their proven effects in the treatment of many diseases. As MSCs are not infected with covid-19, there is evidence that it modulates the immune system and prevents the virus from clotting. Despite the beginning of numerous clinical trials in the use of mesenchymal stem cells, it is necessary to set a practical guideline that specifies items such as cell origin, number of cells, frequency of injection, injection site, etc. SN - 1879-0038 UR - https://www.unboundmedicine.com/medline/citation/33549712/The_use_of_mesenchymal_stem_cells_in_the_process_of_treatment_and_tissue_regeneration_after_recovery_in_patients_with_Covid_19_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-1119(21)00065-2 DB - PRIME DP - Unbound Medicine ER -