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Rates and risk factors for suicidal ideation, suicide attempts and suicide deaths in persons with HIV: a protocol for a systematic review and meta-analysis.
BMJ Open. 2021 02 05; 11(2):e037154.BO

Abstract

INTRODUCTION

The prevalence of HIV/AIDS is high and is associated with psychiatric morbidity and suicide risk. The objective of this study will be to assess the rates of suicidal ideation, suicide attempts and suicide deaths in people living with HIV/AIDS (PLWHA).

METHODS AND ANALYSIS

We present a study protocol for a systematic review and meta-analysis of studies reporting the suicidality outcomes (suicidal ideation, suicide attempts and suicide deaths) in PLWHA. PubMed (MEDLINE), Scopus, EMBASE, Cochrane Library, OVID (HEALTH STAR), OVID (MEDLINE), Joanna Briggs Institute EBP Database, Web of Science and PsychINFO databases will be searched from their inception until 1 January 2020. The primary outcome of interest will be the incidence of suicidality in PLWHA. In addition, we will delineate risk factors associated with suicidality in PLWHA. Citations, full-text articles and abstracts will be screened by four reviewers independently. Disagreements will be resolved through discussion. The study methodological quality (or bias) will be appraised using an appropriate tool. Random-effects meta-analysis will be conducted if we find that the studies are very heterogenous. For the suicidality outcome, probability of suicide risk will be reported. Relative risk ratios (with 95% CIs) will be reported for the effects of the risk factors. Potential publication bias will be assessed by conducting Egger's test and creating funnel plots. We will conduct additional analyses to explore the potential sources of heterogeneity (eg, age, sex and geographical location).

ETHICS AND DISSEMINATION

No ethics clearance is required as no primary data will be collected. The results of this systematic review and meta-analysis will be presented at scientific conferences and published in a peer-reviewed journal. The results may inform clinical management of PLWHA and may guide future population-specific interventions.We will search PubMed (MEDLINE), Scopus, EMBASE, Cochrane Library, OVID (HEALTH STAR), OVID (MEDLINE), Joanna Briggs Institute EBP Database, Web of Science and PsychINFO from their inception until 1 January 2020.

PROSPERO REGISTRATION NUMBER

CRD42020161501.

Links

PMC Free PDF

Authors+Show Affiliations

Wisnousky H
Penn State College of Medicine, Hershey, Pennsylvania, USA.
Lazzara N
Penn State College of Medicine, Hershey, Pennsylvania, USA.
Ciarletta M
Penn State College of Medicine, Hershey, Pennsylvania, USA.
Pelton M
Penn State College of Medicine, Hershey, Pennsylvania, USA.
Chinchilli VM
Public Health Sciences, Penn State Health Milton S Hershey Medical Center, Hershey, Pennsylvania, USA.
Ssentongo AE
Public Health Sciences, Penn State Health Milton S Hershey Medical Center, Hershey, Pennsylvania, USA.
Ssentongo P
Public Health Sciences, Penn State Health Milton S Hershey Medical Center, Hershey, Pennsylvania, USA pssentongo@pennstatehealth.psu.edu. Center for Neural Engineering, Penn State University, University Park, Pennsylvania, USA.

MeSH

HumansIncidenceMeta-Analysis as TopicPrevalenceRisk FactorsSuicidal IdeationSuicide, AttemptedSystematic Reviews as Topic

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33550223

Citation

Wisnousky, Holly, et al. "Rates and Risk Factors for Suicidal Ideation, Suicide Attempts and Suicide Deaths in Persons With HIV: a Protocol for a Systematic Review and Meta-analysis." BMJ Open, vol. 11, no. 2, 2021, pp. e037154.
Wisnousky H, Lazzara N, Ciarletta M, et al. Rates and risk factors for suicidal ideation, suicide attempts and suicide deaths in persons with HIV: a protocol for a systematic review and meta-analysis. BMJ Open. 2021;11(2):e037154.
Wisnousky, H., Lazzara, N., Ciarletta, M., Pelton, M., Chinchilli, V. M., Ssentongo, A. E., & Ssentongo, P. (2021). Rates and risk factors for suicidal ideation, suicide attempts and suicide deaths in persons with HIV: a protocol for a systematic review and meta-analysis. BMJ Open, 11(2), e037154. https://doi.org/10.1136/bmjopen-2020-037154
Wisnousky H, et al. Rates and Risk Factors for Suicidal Ideation, Suicide Attempts and Suicide Deaths in Persons With HIV: a Protocol for a Systematic Review and Meta-analysis. BMJ Open. 2021 02 5;11(2):e037154. PubMed PMID: 33550223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rates and risk factors for suicidal ideation, suicide attempts and suicide deaths in persons with HIV: a protocol for a systematic review and meta-analysis. AU - Wisnousky,Holly, AU - Lazzara,Nick, AU - Ciarletta,Matt, AU - Pelton,Matt, AU - Chinchilli,Vernon M, AU - Ssentongo,Anna E, AU - Ssentongo,Paddy, Y1 - 2021/02/05/ PY - 2021/2/7/entrez PY - 2021/2/8/pubmed PY - 2021/5/15/medline KW - HIV & AIDS KW - epidemiology KW - public health KW - suicide & self-harm SP - e037154 EP - e037154 JF - BMJ open JO - BMJ Open VL - 11 IS - 2 N2 - INTRODUCTION: The prevalence of HIV/AIDS is high and is associated with psychiatric morbidity and suicide risk. The objective of this study will be to assess the rates of suicidal ideation, suicide attempts and suicide deaths in people living with HIV/AIDS (PLWHA). METHODS AND ANALYSIS: We present a study protocol for a systematic review and meta-analysis of studies reporting the suicidality outcomes (suicidal ideation, suicide attempts and suicide deaths) in PLWHA. PubMed (MEDLINE), Scopus, EMBASE, Cochrane Library, OVID (HEALTH STAR), OVID (MEDLINE), Joanna Briggs Institute EBP Database, Web of Science and PsychINFO databases will be searched from their inception until 1 January 2020. The primary outcome of interest will be the incidence of suicidality in PLWHA. In addition, we will delineate risk factors associated with suicidality in PLWHA. Citations, full-text articles and abstracts will be screened by four reviewers independently. Disagreements will be resolved through discussion. The study methodological quality (or bias) will be appraised using an appropriate tool. Random-effects meta-analysis will be conducted if we find that the studies are very heterogenous. For the suicidality outcome, probability of suicide risk will be reported. Relative risk ratios (with 95% CIs) will be reported for the effects of the risk factors. Potential publication bias will be assessed by conducting Egger's test and creating funnel plots. We will conduct additional analyses to explore the potential sources of heterogeneity (eg, age, sex and geographical location). ETHICS AND DISSEMINATION: No ethics clearance is required as no primary data will be collected. The results of this systematic review and meta-analysis will be presented at scientific conferences and published in a peer-reviewed journal. The results may inform clinical management of PLWHA and may guide future population-specific interventions.We will search PubMed (MEDLINE), Scopus, EMBASE, Cochrane Library, OVID (HEALTH STAR), OVID (MEDLINE), Joanna Briggs Institute EBP Database, Web of Science and PsychINFO from their inception until 1 January 2020. PROSPERO REGISTRATION NUMBER: CRD42020161501. SN - 2044-6055 UR - https://www.unboundmedicine.com/medline/citation/33550223/Rates_and_risk_factors_for_suicidal_ideation_suicide_attempts_and_suicide_deaths_in_persons_with_HIV:_a_protocol_for_a_systematic_review_and_meta_analysis_ DB - PRIME DP - Unbound Medicine ER -