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Optimal Allocation of the Limited COVID-19 Vaccine Supply in South Korea.
J Clin Med. 2021 Feb 04; 10(4)JC

Abstract

Initial supply of the coronavirus disease (COVID-19) vaccine may be limited, necessitating its effective use. Herein, an age-structured model of COVID-19 spread in South Korea is parameterized to understand the epidemiological characteristics of COVID-19. The model determines optimal vaccine allocation for minimizing infections, deaths, and years of life lost while accounting for population factors, such as country-specific age distribution and contact structure, and various levels of vaccine efficacy. A transmission-blocking vaccine should be prioritized in adults aged 20-49 years and those older than 50 years to minimize the cumulative incidence and mortality, respectively. A strategy to minimize years of life lost involves the vaccination of adults aged 40-69 years, reflecting the relatively high case-fatality rates and years of life lost in this age group. An incidence-minimizing vaccination strategy is highly sensitive to vaccine efficacy, and vaccines with lower efficacy should be administered to teenagers and adults aged 50-59 years. Consideration of age-specific contact rates and vaccine efficacy is critical to optimize vaccine allocation. New recommendations for COVID-19 vaccines under consideration by the Korean Centers for Disease Control and Prevention are mainly based on a mortality-minimizing allocation strategy.

Authors+Show Affiliations

Department of Mathematics, Soongsil University, Seoul 06978, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33557344

Citation

Shim, Eunha. "Optimal Allocation of the Limited COVID-19 Vaccine Supply in South Korea." Journal of Clinical Medicine, vol. 10, no. 4, 2021.
Shim E. Optimal Allocation of the Limited COVID-19 Vaccine Supply in South Korea. J Clin Med. 2021;10(4).
Shim, E. (2021). Optimal Allocation of the Limited COVID-19 Vaccine Supply in South Korea. Journal of Clinical Medicine, 10(4). https://doi.org/10.3390/jcm10040591
Shim E. Optimal Allocation of the Limited COVID-19 Vaccine Supply in South Korea. J Clin Med. 2021 Feb 4;10(4) PubMed PMID: 33557344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Optimal Allocation of the Limited COVID-19 Vaccine Supply in South Korea. A1 - Shim,Eunha, Y1 - 2021/02/04/ PY - 2020/12/09/received PY - 2021/01/29/revised PY - 2021/02/01/accepted PY - 2021/2/9/entrez PY - 2021/2/10/pubmed PY - 2021/2/10/medline KW - COVID-19 KW - Korea KW - SARS-CoV-2 KW - mathematical model KW - optimal strategy KW - vaccine KW - vaccine allocation strategy JF - Journal of clinical medicine JO - J Clin Med VL - 10 IS - 4 N2 - Initial supply of the coronavirus disease (COVID-19) vaccine may be limited, necessitating its effective use. Herein, an age-structured model of COVID-19 spread in South Korea is parameterized to understand the epidemiological characteristics of COVID-19. The model determines optimal vaccine allocation for minimizing infections, deaths, and years of life lost while accounting for population factors, such as country-specific age distribution and contact structure, and various levels of vaccine efficacy. A transmission-blocking vaccine should be prioritized in adults aged 20-49 years and those older than 50 years to minimize the cumulative incidence and mortality, respectively. A strategy to minimize years of life lost involves the vaccination of adults aged 40-69 years, reflecting the relatively high case-fatality rates and years of life lost in this age group. An incidence-minimizing vaccination strategy is highly sensitive to vaccine efficacy, and vaccines with lower efficacy should be administered to teenagers and adults aged 50-59 years. Consideration of age-specific contact rates and vaccine efficacy is critical to optimize vaccine allocation. New recommendations for COVID-19 vaccines under consideration by the Korean Centers for Disease Control and Prevention are mainly based on a mortality-minimizing allocation strategy. SN - 2077-0383 UR - https://www.unboundmedicine.com/medline/citation/33557344/Optimal_Allocation_of_the_Limited_COVID_19_Vaccine_Supply_in_South_Korea_ L2 - https://www.mdpi.com/resolver?pii=jcm10040591 DB - PRIME DP - Unbound Medicine ER -
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