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Vasectomy, cigarette smoking, and age at first sexual intercourse as risk factors for prostate cancer in middle-aged men.
Br J Cancer 1988; 57(3):326-31BJ

Abstract

A population-based case-control study was conducted in men aged 60 or less to assess the risk of prostate cancer associated with vasectomy and other factors. Data were obtained from 216 case-control pairs by telephone interviews; this number represented 55% of all eligible cases. The matched pairs relative risk (RR) for vasectomy in ever married men was 1.4 with a 95% confidence interval (CI) of 0.9-2.3. There was a positive association between the number of years since vasectomy and prostate cancer risk (1-sided P = 0.01). Early age at first sexual intercourse was associated with increased prostate cancer risk (age less than 17 vs. 21+, RR = 2.3, 95% CI = 1.3, 4.0) but there were no consistent associations with number of sexual partners or frequency of sexual intercourse. Cigarette smoking was also associated with increased risk of prostate cancer (RR = 1.9, 95% CI = 1.2, 3.0) and there was a positive dose-response relationship with years of smoking (1-sided P = 0.001). We discuss the possible implication of the low response rate on each of these findings. To determine whether the association with vasectomy might have a hormonal basis, we compared levels of testosterone (T) and testosterone binding globulin-binding capacity (TeBG-bc) in 33 of the vasectomized control men with levels in 33 non-vasectomized controls of the same age, weight and height. T levels were higher in vasectomized than in non-vasectomized controls (1-sided P = 0.06). The ratio of T to TeBG-bc (an index of bioavailable T) was 13.5% higher in vasectomized men (1-sided P = 0.03).

Authors+Show Affiliations

Tulane University, School of Medicine, New Orleans, Louisiana.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3355774

Citation

Honda, G D., et al. "Vasectomy, Cigarette Smoking, and Age at First Sexual Intercourse as Risk Factors for Prostate Cancer in Middle-aged Men." British Journal of Cancer, vol. 57, no. 3, 1988, pp. 326-31.
Honda GD, Bernstein L, Ross RK, et al. Vasectomy, cigarette smoking, and age at first sexual intercourse as risk factors for prostate cancer in middle-aged men. Br J Cancer. 1988;57(3):326-31.
Honda, G. D., Bernstein, L., Ross, R. K., Greenland, S., Gerkins, V., & Henderson, B. E. (1988). Vasectomy, cigarette smoking, and age at first sexual intercourse as risk factors for prostate cancer in middle-aged men. British Journal of Cancer, 57(3), pp. 326-31.
Honda GD, et al. Vasectomy, Cigarette Smoking, and Age at First Sexual Intercourse as Risk Factors for Prostate Cancer in Middle-aged Men. Br J Cancer. 1988;57(3):326-31. PubMed PMID: 3355774.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vasectomy, cigarette smoking, and age at first sexual intercourse as risk factors for prostate cancer in middle-aged men. AU - Honda,G D, AU - Bernstein,L, AU - Ross,R K, AU - Greenland,S, AU - Gerkins,V, AU - Henderson,B E, PY - 1988/3/1/pubmed PY - 1988/3/1/medline PY - 1988/3/1/entrez KW - Age Factors KW - Alcohol Drinking KW - Americas KW - Androgens KW - Behavior KW - Biology KW - California KW - Control Groups KW - Data Analysis KW - Data Collection KW - Demographic Factors KW - Developed Countries KW - Developing Countries KW - Family Planning KW - Genitalia KW - Genitalia, Male KW - Hormones KW - Male Sterilization KW - Marital Status KW - Marriage KW - Marriage Age KW - Marriage Patterns KW - North America KW - Northern America KW - Nuptiality KW - Physiology KW - Population KW - Population Characteristics KW - Prostate KW - Research Methodology KW - Risk Factors KW - Sex Behavior KW - Smoking KW - Social Behavior KW - Sterilization, Sexual KW - Testosterone KW - United States KW - Urogenital System KW - Vas Occlusion KW - Vasectomy SP - 326 EP - 31 JF - British journal of cancer JO - Br. J. Cancer VL - 57 IS - 3 N2 - A population-based case-control study was conducted in men aged 60 or less to assess the risk of prostate cancer associated with vasectomy and other factors. Data were obtained from 216 case-control pairs by telephone interviews; this number represented 55% of all eligible cases. The matched pairs relative risk (RR) for vasectomy in ever married men was 1.4 with a 95% confidence interval (CI) of 0.9-2.3. There was a positive association between the number of years since vasectomy and prostate cancer risk (1-sided P = 0.01). Early age at first sexual intercourse was associated with increased prostate cancer risk (age less than 17 vs. 21+, RR = 2.3, 95% CI = 1.3, 4.0) but there were no consistent associations with number of sexual partners or frequency of sexual intercourse. Cigarette smoking was also associated with increased risk of prostate cancer (RR = 1.9, 95% CI = 1.2, 3.0) and there was a positive dose-response relationship with years of smoking (1-sided P = 0.001). We discuss the possible implication of the low response rate on each of these findings. To determine whether the association with vasectomy might have a hormonal basis, we compared levels of testosterone (T) and testosterone binding globulin-binding capacity (TeBG-bc) in 33 of the vasectomized control men with levels in 33 non-vasectomized controls of the same age, weight and height. T levels were higher in vasectomized than in non-vasectomized controls (1-sided P = 0.06). The ratio of T to TeBG-bc (an index of bioavailable T) was 13.5% higher in vasectomized men (1-sided P = 0.03). SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/3355774/Vasectomy_cigarette_smoking_and_age_at_first_sexual_intercourse_as_risk_factors_for_prostate_cancer_in_middle_aged_men_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/3355774/ DB - PRIME DP - Unbound Medicine ER -