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Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera.
Nat Med. 2021 04; 27(4):620-621.NMed

Abstract

We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion + N501Y + D614G from UK; and E484K + N501Y + D614G from SA. Neutralization geometric mean titers (GMTs) of 20 BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA. Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, USA.Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA.Pfizer, Pearl River, NY, USA.Pfizer, Pearl River, NY, USA.Pfizer, Pearl River, NY, USA.Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA. Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, USA.Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA. Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, USA.Pfizer, Pearl River, NY, USA. philip.dormitzer@pfizer.com.Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA. peshi@utmb.edu. Institute for Human Infection and Immunity, University of Texas Medical Branch, Galveston, TX, USA. peshi@utmb.edu. Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX, USA. peshi@utmb.edu. Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX, USA. peshi@utmb.edu. Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch, Galveston, TX, USA. peshi@utmb.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33558724

Citation

Xie, Xuping, et al. "Neutralization of SARS-CoV-2 Spike 69/70 Deletion, E484K and N501Y Variants By BNT162b2 Vaccine-elicited Sera." Nature Medicine, vol. 27, no. 4, 2021, pp. 620-621.
Xie X, Liu Y, Liu J, et al. Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera. Nat Med. 2021;27(4):620-621.
Xie, X., Liu, Y., Liu, J., Zhang, X., Zou, J., Fontes-Garfias, C. R., Xia, H., Swanson, K. A., Cutler, M., Cooper, D., Menachery, V. D., Weaver, S. C., Dormitzer, P. R., & Shi, P. Y. (2021). Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera. Nature Medicine, 27(4), 620-621. https://doi.org/10.1038/s41591-021-01270-4
Xie X, et al. Neutralization of SARS-CoV-2 Spike 69/70 Deletion, E484K and N501Y Variants By BNT162b2 Vaccine-elicited Sera. Nat Med. 2021;27(4):620-621. PubMed PMID: 33558724.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neutralization of SARS-CoV-2 spike 69/70 deletion, E484K and N501Y variants by BNT162b2 vaccine-elicited sera. AU - Xie,Xuping, AU - Liu,Yang, AU - Liu,Jianying, AU - Zhang,Xianwen, AU - Zou,Jing, AU - Fontes-Garfias,Camila R, AU - Xia,Hongjie, AU - Swanson,Kena A, AU - Cutler,Mark, AU - Cooper,David, AU - Menachery,Vineet D, AU - Weaver,Scott C, AU - Dormitzer,Philip R, AU - Shi,Pei-Yong, Y1 - 2021/02/08/ PY - 2021/01/08/received PY - 2021/01/28/accepted PY - 2021/2/10/pubmed PY - 2021/4/29/medline PY - 2021/2/9/entrez SP - 620 EP - 621 JF - Nature medicine JO - Nat Med VL - 27 IS - 4 N2 - We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion + N501Y + D614G from UK; and E484K + N501Y + D614G from SA. Neutralization geometric mean titers (GMTs) of 20 BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses. SN - 1546-170X UR - https://www.unboundmedicine.com/medline/citation/33558724/Neutralization_of_SARS_CoV_2_spike_69/70_deletion_E484K_and_N501Y_variants_by_BNT162b2_vaccine_elicited_sera_ L2 - https://doi.org/10.1038/s41591-021-01270-4 DB - PRIME DP - Unbound Medicine ER -