Tags

Type your tag names separated by a space and hit enter

Electrooxidation and Low-tech Determination of Pantoprazole on a Disposable Pencil Graphite Electrode by the use of Cationic Surfactant.
Acta Chim Slov. 2020 Mar; 67(1):212-220.AC

Abstract

The electrochemical oxidation of pantoprazole, a selective proton pump inhibitor, was studied in aqueous as well as aqueous/surfactant media at a disposable pencil graphite electrode using cyclic and adsorptive stripping voltammetric techniques. The sensitivity of the stripping voltammetric measurements was significantly improved when the cationic surfactant, cetyltrimethylammonium bromide (CTAB) was present in the neutral electrolyte solution. For analytical purposes, well resolved voltammetric peaks at +1.05 V (versus Ag/AgCl) were obtained in Britton-Robinson buffer at pH 7.0 containing 3×10-4 M CTAB using square-wave stripping mode (after 30 s accumulation at open-circuit condition). The process could be used to determine pantoprazole concentrations in the range of 2.4×10-8 - 7.1×10-7 M (9.2 - 272 µg L-1) with a detection limit of 7.0×10-9 M (2.7 µg L-1). The proposed method was applied to the determination of pantoprazole in pharmaceutical formulation and in the spiked human urine samples with acceptable recoveries.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33558930

Citation

Pinar, P Nar Talay. "Electrooxidation and Low-tech Determination of Pantoprazole On a Disposable Pencil Graphite Electrode By the Use of Cationic Surfactant." Acta Chimica Slovenica, vol. 67, no. 1, 2020, pp. 212-220.
Pinar PNT. Electrooxidation and Low-tech Determination of Pantoprazole on a Disposable Pencil Graphite Electrode by the use of Cationic Surfactant. Acta Chim Slov. 2020;67(1):212-220.
Pinar, P. N. T. (2020). Electrooxidation and Low-tech Determination of Pantoprazole on a Disposable Pencil Graphite Electrode by the use of Cationic Surfactant. Acta Chimica Slovenica, 67(1), 212-220.
Pinar PNT. Electrooxidation and Low-tech Determination of Pantoprazole On a Disposable Pencil Graphite Electrode By the Use of Cationic Surfactant. Acta Chim Slov. 2020;67(1):212-220. PubMed PMID: 33558930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrooxidation and Low-tech Determination of Pantoprazole on a Disposable Pencil Graphite Electrode by the use of Cationic Surfactant. A1 - Pinar,P Nar Talay, PY - 2021/2/9/entrez PY - 2021/2/10/pubmed PY - 2021/2/10/medline SP - 212 EP - 220 JF - Acta chimica Slovenica JO - Acta Chim Slov VL - 67 IS - 1 N2 - The electrochemical oxidation of pantoprazole, a selective proton pump inhibitor, was studied in aqueous as well as aqueous/surfactant media at a disposable pencil graphite electrode using cyclic and adsorptive stripping voltammetric techniques. The sensitivity of the stripping voltammetric measurements was significantly improved when the cationic surfactant, cetyltrimethylammonium bromide (CTAB) was present in the neutral electrolyte solution. For analytical purposes, well resolved voltammetric peaks at +1.05 V (versus Ag/AgCl) were obtained in Britton-Robinson buffer at pH 7.0 containing 3×10-4 M CTAB using square-wave stripping mode (after 30 s accumulation at open-circuit condition). The process could be used to determine pantoprazole concentrations in the range of 2.4×10-8 - 7.1×10-7 M (9.2 - 272 µg L-1) with a detection limit of 7.0×10-9 M (2.7 µg L-1). The proposed method was applied to the determination of pantoprazole in pharmaceutical formulation and in the spiked human urine samples with acceptable recoveries. SN - 1580-3155 UR - https://www.unboundmedicine.com/medline/citation/33558930/Electrooxidation_and_Low_tech_Determination_of_Pantoprazole_on_a_Disposable_Pencil_Graphite_Electrode_by_the_use_of_Cationic_Surfactant_ DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.