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Assessment of Cota altissima (L.) J. Gay for phytochemical composition and antioxidant, anti-inflammatory, antidiabetic and antimicrobial activities.
Z Naturforsch C J Biosci. 2021 Jul 27; 76(7-8):317-327.ZN

Abstract

Phytochemical profiles of essential oil (EO), fatty acids, and n-hexane (CAH), diethyl ether (CAD), ethyl acetate (CAE) and methanol extracts (CAM) of Cota altissima L. J. Gay (syn. Anthemis altissima L.) were investigated as well as their antioxidant, anti-inflammatory, antidiabetic and antimicrobial activites. The essential oil was characterized by the content of acetophenone (35.8%) and β-caryophyllene (10.3%) by GC-MS/FID. Linoleic and oleic acid were found as main fatty acids. The major constituents of the extracts were found to be 5-caffeoylquinic acid, 3,5-dicaffeoylquinic acid, isorhamnetin glucoside, quercetin and quercetin glucoside by LC-MS/MS. Antioxidant activities of the extracts were determined by scavenging of DPPH and ABTS free radicals. Also, the inhibitory effects on lipoxygenase and α-glucosidase enzymes were determined. Antimicrobial activity was evaluated against Gram positive, Gram negative bacteria and yeast pathogens. CAM showed the highest antioxidant activity against DPPH and ABTS radicals with IC50 values of 126.60 and 144.40 μg/mL, respectively. In the anti-inflammatory activity, CAE demonstrated the highest antilipoxygenase activity with an IC50 value of 105.40 μg/mL, whereas, CAD showed the best inhibition of α-glucosidase with an IC50 value of 396.40 μg/mL in the antidiabetic activity. CAH was effective against Staphylococcus aureus at MIC = 312.5 µg/mL. This is the first report on antidiabetic, anti-inflammatory and antimicrobial activities of different extracts of C. altissima.

Authors+Show Affiliations

Department of Pharmacognosy, Faculty of Pharmacy, Trakya University, Edirne, Turkey.Faculty of Pharmacy, Trakya University, Edirne, Turkey.Deparment of Pharmacognosy, Faculty of Pharmacy, Marmara University, Istanbul, Turkey.Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskişehir, 26470, Turkey.Department of Pharmaceutical Botany, Faculty of Pharmacy, Trakya University, Edirne, Turkey.Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskişehir, 26470, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33559461

Citation

Göger, Gamze, et al. "Assessment of Cota Altissima (L.) J. Gay for Phytochemical Composition and Antioxidant, Anti-inflammatory, Antidiabetic and Antimicrobial Activities." Zeitschrift Fur Naturforschung. C, Journal of Biosciences, vol. 76, no. 7-8, 2021, pp. 317-327.
Göger G, Allak M, Şen A, et al. Assessment of Cota altissima (L.) J. Gay for phytochemical composition and antioxidant, anti-inflammatory, antidiabetic and antimicrobial activities. Z Naturforsch C J Biosci. 2021;76(7-8):317-327.
Göger, G., Allak, M., Şen, A., Göger, F., Tekin, M., & Özek, G. (2021). Assessment of Cota altissima (L.) J. Gay for phytochemical composition and antioxidant, anti-inflammatory, antidiabetic and antimicrobial activities. Zeitschrift Fur Naturforschung. C, Journal of Biosciences, 76(7-8), 317-327. https://doi.org/10.1515/znc-2020-0257
Göger G, et al. Assessment of Cota Altissima (L.) J. Gay for Phytochemical Composition and Antioxidant, Anti-inflammatory, Antidiabetic and Antimicrobial Activities. Z Naturforsch C J Biosci. 2021 Jul 27;76(7-8):317-327. PubMed PMID: 33559461.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of Cota altissima (L.) J. Gay for phytochemical composition and antioxidant, anti-inflammatory, antidiabetic and antimicrobial activities. AU - Göger,Gamze, AU - Allak,Muhammed, AU - Şen,Ali, AU - Göger,Fatih, AU - Tekin,Mehmet, AU - Özek,Gülmira, Y1 - 2021/02/09/ PY - 2020/10/22/received PY - 2021/01/14/accepted PY - 2021/2/10/pubmed PY - 2021/12/28/medline PY - 2021/2/9/entrez KW - Cota altissima KW - GC-MS/FID KW - LC-MS/MS KW - activity KW - essential oil KW - extract SP - 317 EP - 327 JF - Zeitschrift fur Naturforschung. C, Journal of biosciences JO - Z Naturforsch C J Biosci VL - 76 IS - 7-8 N2 - Phytochemical profiles of essential oil (EO), fatty acids, and n-hexane (CAH), diethyl ether (CAD), ethyl acetate (CAE) and methanol extracts (CAM) of Cota altissima L. J. Gay (syn. Anthemis altissima L.) were investigated as well as their antioxidant, anti-inflammatory, antidiabetic and antimicrobial activites. The essential oil was characterized by the content of acetophenone (35.8%) and β-caryophyllene (10.3%) by GC-MS/FID. Linoleic and oleic acid were found as main fatty acids. The major constituents of the extracts were found to be 5-caffeoylquinic acid, 3,5-dicaffeoylquinic acid, isorhamnetin glucoside, quercetin and quercetin glucoside by LC-MS/MS. Antioxidant activities of the extracts were determined by scavenging of DPPH and ABTS free radicals. Also, the inhibitory effects on lipoxygenase and α-glucosidase enzymes were determined. Antimicrobial activity was evaluated against Gram positive, Gram negative bacteria and yeast pathogens. CAM showed the highest antioxidant activity against DPPH and ABTS radicals with IC50 values of 126.60 and 144.40 μg/mL, respectively. In the anti-inflammatory activity, CAE demonstrated the highest antilipoxygenase activity with an IC50 value of 105.40 μg/mL, whereas, CAD showed the best inhibition of α-glucosidase with an IC50 value of 396.40 μg/mL in the antidiabetic activity. CAH was effective against Staphylococcus aureus at MIC = 312.5 µg/mL. This is the first report on antidiabetic, anti-inflammatory and antimicrobial activities of different extracts of C. altissima. SN - 1865-7125 UR - https://www.unboundmedicine.com/medline/citation/33559461/Assessment_of_Cota_altissima__L___J__Gay_for_phytochemical_composition_and_antioxidant_anti_inflammatory_antidiabetic_and_antimicrobial_activities_ L2 - https://www.degruyter.com/document/doi/10.1515/znc-2020-0257 DB - PRIME DP - Unbound Medicine ER -