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The Sustained Therapeutic Effects of Percutaneous Posterior Tibial Nerve Stimulation in the Treatment of Neurogenic Lower Urinary Tract Symptoms in Patients with Parkinson's Disease: 24-months Clinical and Urodynamic Results.
Urology. 2021 07; 153:49-55.U

Abstract

OBJECTIVE

To determine the sustained therapeutic effect of percutaneous posterior tibial nerve stimulation (PTNS) treatment in Parkinson's disease patients with detrusor activity during 24 months.

METHODS

After 12 weeks therapy, PTNS was applied at 14-day intervals for 3 months, 21-day intervals for 3 months and 28-day intervals through 24 months. The patients completed a 3-day voiding diary and ICIQ-SF, OAB-V8, OAB-q SF questionnaires at 3rd, 6th, 9th,12th and 24th month.

RESULTS

A total of 76 patients were enrolled in the study. Of these 44 (57.9%) were men and 32 (42.1%) women. The differences of compared parameters at baseline and at the end of 24 months were as follows; daytime frequency decreased by 4.6 voids daily, urge incontinence decreased by 4.2 episodes daily, urgency episodes decreased by 6.2 episodes daily, nocturia decreased by 2.4 voids (P <.001) and voided volume improved by a mean of 71.4 cc (P <.05). When compared with baseline significant improvements were seen in the volume at the first involuntary detrusor contraction (1st IDCV), maximum cystometric capacity (MCC), maximal detrusor pressure at first involuntary detrusor contraction (1st IDC Pdetmax), maximal detrusor pressure at MCC (MCC Pdetmax), detrusor pressure at maximal flow (PdetQmax) and post-void residual volume (PVR) after PTNS treatment at 3, 12, 24 months (P <.001 for each) except maximal flow rate (Qmax) value (P ˃.05).

CONCLUSIONS

These results have demonstrated the significant improvements both on voiding and urodynamic parameters under PTNS treatment with a tapering protocol for during 24-months in Parkinson's disease with detrusor activity.

Authors+Show Affiliations

Altinbas University Faculty of Medicine, Department of Urology Istanbul, Turkey. Electronic address: skabay@yahoo.com.Kutahya Health Sciences University, Faculty of Medicine, Department of Neurology Kutahya, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33561470

Citation

Kabay, Sahin, and Sibel Canbaz Kabay. "The Sustained Therapeutic Effects of Percutaneous Posterior Tibial Nerve Stimulation in the Treatment of Neurogenic Lower Urinary Tract Symptoms in Patients With Parkinson's Disease: 24-months Clinical and Urodynamic Results." Urology, vol. 153, 2021, pp. 49-55.
Kabay S, Kabay SC. The Sustained Therapeutic Effects of Percutaneous Posterior Tibial Nerve Stimulation in the Treatment of Neurogenic Lower Urinary Tract Symptoms in Patients with Parkinson's Disease: 24-months Clinical and Urodynamic Results. Urology. 2021;153:49-55.
Kabay, S., & Kabay, S. C. (2021). The Sustained Therapeutic Effects of Percutaneous Posterior Tibial Nerve Stimulation in the Treatment of Neurogenic Lower Urinary Tract Symptoms in Patients with Parkinson's Disease: 24-months Clinical and Urodynamic Results. Urology, 153, 49-55. https://doi.org/10.1016/j.urology.2021.01.044
Kabay S, Kabay SC. The Sustained Therapeutic Effects of Percutaneous Posterior Tibial Nerve Stimulation in the Treatment of Neurogenic Lower Urinary Tract Symptoms in Patients With Parkinson's Disease: 24-months Clinical and Urodynamic Results. Urology. 2021;153:49-55. PubMed PMID: 33561470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Sustained Therapeutic Effects of Percutaneous Posterior Tibial Nerve Stimulation in the Treatment of Neurogenic Lower Urinary Tract Symptoms in Patients with Parkinson's Disease: 24-months Clinical and Urodynamic Results. AU - Kabay,Sahin, AU - Kabay,Sibel Canbaz, Y1 - 2021/02/06/ PY - 2020/12/07/received PY - 2021/01/24/revised PY - 2021/01/26/accepted PY - 2021/2/10/pubmed PY - 2022/2/10/medline PY - 2021/2/9/entrez SP - 49 EP - 55 JF - Urology JO - Urology VL - 153 N2 - OBJECTIVE: To determine the sustained therapeutic effect of percutaneous posterior tibial nerve stimulation (PTNS) treatment in Parkinson's disease patients with detrusor activity during 24 months. METHODS: After 12 weeks therapy, PTNS was applied at 14-day intervals for 3 months, 21-day intervals for 3 months and 28-day intervals through 24 months. The patients completed a 3-day voiding diary and ICIQ-SF, OAB-V8, OAB-q SF questionnaires at 3rd, 6th, 9th,12th and 24th month. RESULTS: A total of 76 patients were enrolled in the study. Of these 44 (57.9%) were men and 32 (42.1%) women. The differences of compared parameters at baseline and at the end of 24 months were as follows; daytime frequency decreased by 4.6 voids daily, urge incontinence decreased by 4.2 episodes daily, urgency episodes decreased by 6.2 episodes daily, nocturia decreased by 2.4 voids (P <.001) and voided volume improved by a mean of 71.4 cc (P <.05). When compared with baseline significant improvements were seen in the volume at the first involuntary detrusor contraction (1st IDCV), maximum cystometric capacity (MCC), maximal detrusor pressure at first involuntary detrusor contraction (1st IDC Pdetmax), maximal detrusor pressure at MCC (MCC Pdetmax), detrusor pressure at maximal flow (PdetQmax) and post-void residual volume (PVR) after PTNS treatment at 3, 12, 24 months (P <.001 for each) except maximal flow rate (Qmax) value (P ˃.05). CONCLUSIONS: These results have demonstrated the significant improvements both on voiding and urodynamic parameters under PTNS treatment with a tapering protocol for during 24-months in Parkinson's disease with detrusor activity. SN - 1527-9995 UR - https://www.unboundmedicine.com/medline/citation/33561470/The_Sustained_Therapeutic_Effects_of_Percutaneous_Posterior_Tibial_Nerve_Stimulation_in_the_Treatment_of_Neurogenic_Lower_Urinary_Tract_Symptoms_in_Patients_with_Parkinson's_Disease:_24_months_Clinical_and_Urodynamic_Results_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-4295(21)00151-5 DB - PRIME DP - Unbound Medicine ER -