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Potential of Caffeine in Alzheimer's Disease-A Review of Experimental Studies.
Nutrients. 2021 Feb 06; 13(2)N

Abstract

Alzheimer's disease (AD) is the most common type of dementia leading to progressive memory loss and cognitive impairment. Considering that pharmacological treatment options for AD are few and not satisfactory, increasing attention is being paid to dietary components that may affect the development of the disease. Such a dietary component may be caffeine contained in coffee, tea or energy drinks. Although epidemiological data suggest that caffeine intake may counteract the development of cognitive impairment, results of those studies are not conclusive. The aim of the present study is to review the existing experimental studies on the efficacy of caffeine against AD and AD-related cognitive impairment, focusing on the proposed protective mechanisms of action. In conclusion, the reports of studies on experimental AD models generally supported the notion that caffeine may exert some beneficial effects in AD. However, further studies are necessary to elucidate the role of caffeine in the effects of its sources on cognition and possibly AD risk.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Katowice, Jagiellońska 4, 41-200 Sosnowiec, Poland.Department of Pharmacology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Katowice, Jagiellońska 4, 41-200 Sosnowiec, Poland.Department of Pharmacology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Katowice, Jagiellońska 4, 41-200 Sosnowiec, Poland.Department of Pharmacology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Katowice, Jagiellońska 4, 41-200 Sosnowiec, Poland.Department of Pharmacology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Katowice, Jagiellońska 4, 41-200 Sosnowiec, Poland.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33562156

Citation

Londzin, Piotr, et al. "Potential of Caffeine in Alzheimer's Disease-A Review of Experimental Studies." Nutrients, vol. 13, no. 2, 2021.
Londzin P, Zamora M, Kąkol B, et al. Potential of Caffeine in Alzheimer's Disease-A Review of Experimental Studies. Nutrients. 2021;13(2).
Londzin, P., Zamora, M., Kąkol, B., Taborek, A., & Folwarczna, J. (2021). Potential of Caffeine in Alzheimer's Disease-A Review of Experimental Studies. Nutrients, 13(2). https://doi.org/10.3390/nu13020537
Londzin P, et al. Potential of Caffeine in Alzheimer's Disease-A Review of Experimental Studies. Nutrients. 2021 Feb 6;13(2) PubMed PMID: 33562156.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential of Caffeine in Alzheimer's Disease-A Review of Experimental Studies. AU - Londzin,Piotr, AU - Zamora,Milena, AU - Kąkol,Beata, AU - Taborek,Aleksandra, AU - Folwarczna,Joanna, Y1 - 2021/02/06/ PY - 2020/12/31/received PY - 2021/01/29/revised PY - 2021/02/02/accepted PY - 2021/2/10/entrez PY - 2021/2/11/pubmed PY - 2021/5/7/medline KW - Alzheimer’s disease KW - caffeine KW - coffee KW - experimental Alzheimer’s disease models JF - Nutrients JO - Nutrients VL - 13 IS - 2 N2 - Alzheimer's disease (AD) is the most common type of dementia leading to progressive memory loss and cognitive impairment. Considering that pharmacological treatment options for AD are few and not satisfactory, increasing attention is being paid to dietary components that may affect the development of the disease. Such a dietary component may be caffeine contained in coffee, tea or energy drinks. Although epidemiological data suggest that caffeine intake may counteract the development of cognitive impairment, results of those studies are not conclusive. The aim of the present study is to review the existing experimental studies on the efficacy of caffeine against AD and AD-related cognitive impairment, focusing on the proposed protective mechanisms of action. In conclusion, the reports of studies on experimental AD models generally supported the notion that caffeine may exert some beneficial effects in AD. However, further studies are necessary to elucidate the role of caffeine in the effects of its sources on cognition and possibly AD risk. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/33562156/Potential_of_Caffeine_in_Alzheimer's_Disease_A_Review_of_Experimental_Studies_ DB - PRIME DP - Unbound Medicine ER -