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Cannabis: A Toxin-Producing Plant with Potential Therapeutic Uses.
Toxins (Basel). 2021 02 05; 13(2)T

Abstract

For thousands of years, Cannabis sativa has been utilized as a medicine and for recreational and spiritual purposes. Phytocannabinoids are a family of compounds that are found in the cannabis plant, which is known for its psychotogenic and euphoric effects; the main psychotropic constituent of cannabis is Δ9-tetrahydrocannabinol (Δ9-THC). The pharmacological effects of cannabinoids are a result of interactions between those compounds and cannabinoid receptors, CB1 and CB2, located in many parts of the human body. Cannabis is used as a therapeutic agent for treating pain and emesis. Some cannabinoids are clinically applied for treating chronic pain, particularly cancer and multiple sclerosis-associated pain, for appetite stimulation and anti-emesis in HIV/AIDS and cancer patients, and for spasticity treatment in multiple sclerosis and epilepsy patients. Medical cannabis varies from recreational cannabis in the chemical content of THC and cannabidiol (CBD), modes of administration, and safety. Despite the therapeutic effects of cannabis, exposure to high concentrations of THC, the main compound that is responsible for most of the intoxicating effects experienced by users, could lead to psychological events and adverse effects that affect almost all body systems, such as neurological (dizziness, drowsiness, seizures, coma, and others), ophthalmological (mydriasis and conjunctival hyperemia), cardiovascular (tachycardia and arterial hypertension), and gastrointestinal (nausea, vomiting, and thirst), mainly associated with recreational use. Cannabis toxicity in children is more concerning and can cause serious adverse effects such as acute neurological symptoms (stupor), lethargy, seizures, and even coma. More countries are legalizing the commercial production and sale of cannabis for medicinal use, and some for recreational use as well. Liberalization of cannabis laws has led to increased incidence of toxicity, hyperemesis syndrome, lung disease cardiovascular disease, reduced fertility, tolerance, and dependence with chronic prolonged use. This review focuses on the potential therapeutic effects of cannabis and cannabinoids, as well as the acute and chronic toxic effects of cannabis use on various body systems.

Authors+Show Affiliations

Pharmaceutical Sciences Department, Faculty of Pharmacy, Al-Quds University, Jerusalem Abu Dis P144, Palestine.Pharmaceutical Sciences Department, Faculty of Pharmacy, Al-Quds University, Jerusalem Abu Dis P144, Palestine.Department of Sciences, University of Basilicata, 85100 Potenza, Italy. Department of Geography, Environmental Management & Energy Studies, University of Johannesburg, Johannesburg 2092, South Africa.Pharmaceutical Sciences Department, Faculty of Pharmacy, Al-Quds University, Jerusalem Abu Dis P144, Palestine. Department of Sciences, University of Basilicata, 85100 Potenza, Italy.Department of European Cultures (DICEM), University of Basilicata, 75100 Matera, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33562446

Citation

Breijyeh, Zeinab, et al. "Cannabis: a Toxin-Producing Plant With Potential Therapeutic Uses." Toxins, vol. 13, no. 2, 2021.
Breijyeh Z, Jubeh B, Bufo SA, et al. Cannabis: A Toxin-Producing Plant with Potential Therapeutic Uses. Toxins (Basel). 2021;13(2).
Breijyeh, Z., Jubeh, B., Bufo, S. A., Karaman, R., & Scrano, L. (2021). Cannabis: A Toxin-Producing Plant with Potential Therapeutic Uses. Toxins, 13(2). https://doi.org/10.3390/toxins13020117
Breijyeh Z, et al. Cannabis: a Toxin-Producing Plant With Potential Therapeutic Uses. Toxins (Basel). 2021 02 5;13(2) PubMed PMID: 33562446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabis: A Toxin-Producing Plant with Potential Therapeutic Uses. AU - Breijyeh,Zeinab, AU - Jubeh,Buthaina, AU - Bufo,Sabino A, AU - Karaman,Rafik, AU - Scrano,Laura, Y1 - 2021/02/05/ PY - 2020/12/31/received PY - 2021/01/31/revised PY - 2021/02/01/accepted PY - 2021/2/10/entrez PY - 2021/2/11/pubmed PY - 2021/7/1/medline KW - Cannabis sativa KW - abuse KW - cannabinoid receptors KW - cannabinoids KW - endocannabinoids KW - hemp KW - marijuana KW - therapeutics KW - toxicity KW - Δ-9-tetrahydrocannabinol (THC) JF - Toxins JO - Toxins (Basel) VL - 13 IS - 2 N2 - For thousands of years, Cannabis sativa has been utilized as a medicine and for recreational and spiritual purposes. Phytocannabinoids are a family of compounds that are found in the cannabis plant, which is known for its psychotogenic and euphoric effects; the main psychotropic constituent of cannabis is Δ9-tetrahydrocannabinol (Δ9-THC). The pharmacological effects of cannabinoids are a result of interactions between those compounds and cannabinoid receptors, CB1 and CB2, located in many parts of the human body. Cannabis is used as a therapeutic agent for treating pain and emesis. Some cannabinoids are clinically applied for treating chronic pain, particularly cancer and multiple sclerosis-associated pain, for appetite stimulation and anti-emesis in HIV/AIDS and cancer patients, and for spasticity treatment in multiple sclerosis and epilepsy patients. Medical cannabis varies from recreational cannabis in the chemical content of THC and cannabidiol (CBD), modes of administration, and safety. Despite the therapeutic effects of cannabis, exposure to high concentrations of THC, the main compound that is responsible for most of the intoxicating effects experienced by users, could lead to psychological events and adverse effects that affect almost all body systems, such as neurological (dizziness, drowsiness, seizures, coma, and others), ophthalmological (mydriasis and conjunctival hyperemia), cardiovascular (tachycardia and arterial hypertension), and gastrointestinal (nausea, vomiting, and thirst), mainly associated with recreational use. Cannabis toxicity in children is more concerning and can cause serious adverse effects such as acute neurological symptoms (stupor), lethargy, seizures, and even coma. More countries are legalizing the commercial production and sale of cannabis for medicinal use, and some for recreational use as well. Liberalization of cannabis laws has led to increased incidence of toxicity, hyperemesis syndrome, lung disease cardiovascular disease, reduced fertility, tolerance, and dependence with chronic prolonged use. This review focuses on the potential therapeutic effects of cannabis and cannabinoids, as well as the acute and chronic toxic effects of cannabis use on various body systems. SN - 2072-6651 UR - https://www.unboundmedicine.com/medline/citation/33562446/Cannabis:_A_Toxin_Producing_Plant_with_Potential_Therapeutic_Uses_ L2 - https://www.mdpi.com/resolver?pii=toxins13020117 DB - PRIME DP - Unbound Medicine ER -