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A study of swine dysentery by immunofluorescence and histology.
Vet Pathol. 1977 Sep; 14(5):490-507.VP

Abstract

Twenty-six specific-pathogen-free pigs were fed pure cultures of Treponema hyodysenteriae. Five untreated pigs were controls. Distribution of this large spirochete in pigs with swine dysentery was shown by the indirect fluorescent antibody technique. Findings by this method were compared with those from dark-field examination of colonic mucosal scrapings and from tissue sections. The cultures caused mucohemorrhagic colitis which by 10 days after inoculation was indistinguishable from the colitis of swine dysentery. Control pigs remained normal. Pigs killed when spirochetes were first seen in the feces had normal colonic mucosa with only a few spirochetes. At the first sign of diarrhea, however, the colonic mucosa was thicker than normal and had many spirochetes. T. hyodysenteriae was confined to regions of hypertrophy and exudation of the large intestine mucosa throughout the course of disease.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

335630

Citation

Hughes, R, et al. "A Study of Swine Dysentery By Immunofluorescence and Histology." Veterinary Pathology, vol. 14, no. 5, 1977, pp. 490-507.
Hughes R, Olander HJ, Kanitz DL, et al. A study of swine dysentery by immunofluorescence and histology. Vet Pathol. 1977;14(5):490-507.
Hughes, R., Olander, H. J., Kanitz, D. L., & Qureshi, S. (1977). A study of swine dysentery by immunofluorescence and histology. Veterinary Pathology, 14(5), 490-507.
Hughes R, et al. A Study of Swine Dysentery By Immunofluorescence and Histology. Vet Pathol. 1977;14(5):490-507. PubMed PMID: 335630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A study of swine dysentery by immunofluorescence and histology. AU - Hughes,R, AU - Olander,H J, AU - Kanitz,D L, AU - Qureshi,S, PY - 1977/9/1/pubmed PY - 1977/9/1/medline PY - 1977/9/1/entrez SP - 490 EP - 507 JF - Veterinary pathology JO - Vet. Pathol. VL - 14 IS - 5 N2 - Twenty-six specific-pathogen-free pigs were fed pure cultures of Treponema hyodysenteriae. Five untreated pigs were controls. Distribution of this large spirochete in pigs with swine dysentery was shown by the indirect fluorescent antibody technique. Findings by this method were compared with those from dark-field examination of colonic mucosal scrapings and from tissue sections. The cultures caused mucohemorrhagic colitis which by 10 days after inoculation was indistinguishable from the colitis of swine dysentery. Control pigs remained normal. Pigs killed when spirochetes were first seen in the feces had normal colonic mucosa with only a few spirochetes. At the first sign of diarrhea, however, the colonic mucosa was thicker than normal and had many spirochetes. T. hyodysenteriae was confined to regions of hypertrophy and exudation of the large intestine mucosa throughout the course of disease. SN - 0300-9858 UR - https://www.unboundmedicine.com/medline/citation/335630/A_study_of_swine_dysentery_by_immunofluorescence_and_histology_ L2 - http://journals.sagepub.com/doi/full/10.1177/030098587701400509?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -