TY - JOUR T1 - The Key Role of Nucleic Acid Vaccines for One Health. AU - Fomsgaard,Anders, AU - Liu,Margaret A, Y1 - 2021/02/08/ PY - 2021/01/13/received PY - 2021/02/02/revised PY - 2021/02/05/accepted PY - 2021/2/11/entrez PY - 2021/2/12/pubmed PY - 2021/3/11/medline KW - Cytolytic T Lymphocyte (CTL) KW - DNA vaccines KW - immune responses KW - mRNA vaccines KW - one health KW - plasmid JF - Viruses JO - Viruses VL - 13 IS - 2 N2 - The ongoing SARS-CoV-2 pandemic has highlighted both the importance of One Health, i.e., the interactions and transmission of pathogens between animals and humans, and the potential power of gene-based vaccines, specifically nucleic acid vaccines. This review will highlight key aspects of the development of plasmid DNA Nucleic Acid (NA) vaccines, which have been licensed for several veterinary uses, and tested for a number of human diseases, and will explain how an understanding of their immunological and real-world attributes are important for their efficacy, and how they helped pave the way for mRNA vaccines. The review highlights how combining efforts for vaccine development for both animals and humans is crucial for advancing new technologies and for combatting emerging diseases. SN - 1999-4915 UR - https://www.unboundmedicine.com/medline/citation/33567520/The_Key_Role_of_Nucleic_Acid_Vaccines_for_One_Health_ DB - PRIME DP - Unbound Medicine ER -