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Electric Blue: Molecular Evolution of Three-Finger Toxins in the Long-Glanded Coral Snake Species Calliophis bivirgatus.
Toxins (Basel). 2021 02 08; 13(2)T

Abstract

The genus Calliophis is the most basal branch of the family Elapidae and several species in it have developed highly elongated venom glands. Recent research has shown that C. bivirgatus has evolved a seemingly unique toxin (calliotoxin) that produces spastic paralysis in their prey by acting on the voltage-gated sodium (NaV) channels. We assembled a transcriptome from C. bivirgatus to investigate the molecular characteristics of these toxins and the venom as a whole. We find strong confirmation that this genus produces the classic elapid eight-cysteine three-finger toxins, that δδ-elapitoxins (toxins that resemble calliotoxin) are responsible for a substantial portion of the venom composition, and that these toxins form a distinct clade within a larger, more diverse clade of C. bivirgatus three-finger toxins. This broader clade of C. bivirgatus toxins also contains the previously named maticotoxins and is somewhat closely related to cytotoxins from other elapids. However, the toxins from this clade that have been characterized are not themselves cytotoxic. No other toxins show clear relationships to toxins of known function from other species.

Authors+Show Affiliations

Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia. Australian National Insect Collection, Commonwealth Science and Industry Research Organization, Canberra, ACT 2601, Australia.Department of Biological Sciences, Florida State University, Tallahassee, FL 24105, USA.MToxins Venom Lab, 717 Oregon Street, Oshkosh, WI 54902, USA.School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, QLD 4072, Australia.Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33567660

Citation

Dashevsky, Daniel, et al. "Electric Blue: Molecular Evolution of Three-Finger Toxins in the Long-Glanded Coral Snake Species Calliophis Bivirgatus." Toxins, vol. 13, no. 2, 2021.
Dashevsky D, Rokyta D, Frank N, et al. Electric Blue: Molecular Evolution of Three-Finger Toxins in the Long-Glanded Coral Snake Species Calliophis bivirgatus. Toxins (Basel). 2021;13(2).
Dashevsky, D., Rokyta, D., Frank, N., Nouwens, A., & Fry, B. G. (2021). Electric Blue: Molecular Evolution of Three-Finger Toxins in the Long-Glanded Coral Snake Species Calliophis bivirgatus. Toxins, 13(2). https://doi.org/10.3390/toxins13020124
Dashevsky D, et al. Electric Blue: Molecular Evolution of Three-Finger Toxins in the Long-Glanded Coral Snake Species Calliophis Bivirgatus. Toxins (Basel). 2021 02 8;13(2) PubMed PMID: 33567660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electric Blue: Molecular Evolution of Three-Finger Toxins in the Long-Glanded Coral Snake Species Calliophis bivirgatus. AU - Dashevsky,Daniel, AU - Rokyta,Darin, AU - Frank,Nathaniel, AU - Nouwens,Amanda, AU - Fry,Bryan G, Y1 - 2021/02/08/ PY - 2020/12/17/received PY - 2021/02/04/revised PY - 2021/02/05/accepted PY - 2021/2/11/entrez PY - 2021/2/12/pubmed PY - 2021/2/12/medline KW - blue coral snake KW - three-finger toxin KW - transcriptomics KW - venomics JF - Toxins JO - Toxins (Basel) VL - 13 IS - 2 N2 - The genus Calliophis is the most basal branch of the family Elapidae and several species in it have developed highly elongated venom glands. Recent research has shown that C. bivirgatus has evolved a seemingly unique toxin (calliotoxin) that produces spastic paralysis in their prey by acting on the voltage-gated sodium (NaV) channels. We assembled a transcriptome from C. bivirgatus to investigate the molecular characteristics of these toxins and the venom as a whole. We find strong confirmation that this genus produces the classic elapid eight-cysteine three-finger toxins, that δδ-elapitoxins (toxins that resemble calliotoxin) are responsible for a substantial portion of the venom composition, and that these toxins form a distinct clade within a larger, more diverse clade of C. bivirgatus three-finger toxins. This broader clade of C. bivirgatus toxins also contains the previously named maticotoxins and is somewhat closely related to cytotoxins from other elapids. However, the toxins from this clade that have been characterized are not themselves cytotoxic. No other toxins show clear relationships to toxins of known function from other species. SN - 2072-6651 UR - https://www.unboundmedicine.com/medline/citation/33567660/Electric_Blue:_Molecular_Evolution_of_Three_Finger_Toxins_in_the_Long_Glanded_Coral_Snake_Species_Calliophis_bivirgatus_ L2 - https://www.mdpi.com/resolver?pii=toxins13020124 DB - PRIME DP - Unbound Medicine ER -
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