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Alcohol, coffee and tea intake and the risk of cognitive deficits: a dose-response meta-analysis.
Epidemiol Psychiatr Sci. 2021 Feb 11; 30:e13.EP

Abstract

AIMS

Lifestyle interventions are an important and viable approach for preventing cognitive deficits. However, the results of studies on alcohol, coffee and tea consumption in relation to cognitive decline have been divergent, likely due to confounds from dose-response effects. This meta-analysis aimed to find the dose-response relationship between alcohol, coffee or tea consumption and cognitive deficits.

METHODS

Prospective cohort studies or nested case-control studies in a cohort investigating the risk factors of cognitive deficits were searched in PubMed, Embase, the Cochrane and Web of Science up to 4th June 2020. Two authors searched the databases and extracted the data independently. We also assessed the quality of the studies with the Newcastle-Ottawa scale. Stata 15.0 software was used to perform model estimation and plot the linear or nonlinear dose-response relationship graphs.

RESULTS

The search identified 29 prospective studies from America, Japan, China and some European countries. The dose-response relationships showed that compared to non-drinkers, low consumption (<11 g/day) of alcohol could reduce the risk of cognitive deficits or only dementias, but there was no significant effect of heavier drinking (>11 g/day). Low consumption of coffee reduced the risk of any cognitive deficit (<2.8 cups/day) or dementia (<2.3 cups/day). Green tea consumption was a significant protective factor for cognitive health (relative risk, 0.94; 95% confidence intervals, 0.92-0.97), with one cup of tea per day brings a 6% reduction in risk of cognitive deficits.

CONCLUSIONS

Light consumption of alcohol (<11 g/day) and coffee (<2.8 cups/day) was associated with reduced risk of cognitive deficits. Cognitive benefits of green tea consumption increased with the daily consumption.

Links

Authors+Show Affiliations

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Clinical Research Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

MeSH

Alcohol DrinkingCoffeeCognitionCognition DisordersCognitive DysfunctionDose-Response Relationship, DrugFemaleHumansRisk FactorsTea

Pub Type(s)

Journal Article

Meta-Analysis

Language

eng

PubMed ID

33568254

Citation

Ran, L S., et al. "Alcohol, Coffee and Tea Intake and the Risk of Cognitive Deficits: a Dose-response Meta-analysis." Epidemiology and Psychiatric Sciences, vol. 30, 2021, pp. e13.

Ran LS, Liu WH, Fang YY, et al. Alcohol, coffee and tea intake and the risk of cognitive deficits: a dose-response meta-analysis. Epidemiol Psychiatr Sci. 2021;30:e13.

Ran, L. S., Liu, W. H., Fang, Y. Y., Xu, S. B., Li, J., Luo, X., Pan, D. J., Wang, M. H., & Wang, W. (2021). Alcohol, coffee and tea intake and the risk of cognitive deficits: a dose-response meta-analysis. Epidemiology and Psychiatric Sciences, 30, e13. https://doi.org/10.1017/S2045796020001183

Ran LS, et al. Alcohol, Coffee and Tea Intake and the Risk of Cognitive Deficits: a Dose-response Meta-analysis. Epidemiol Psychiatr Sci. 2021 Feb 11;30:e13. PubMed PMID: 33568254.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Alcohol, coffee and tea intake and the risk of cognitive deficits: a dose-response meta-analysis. AU - Ran,L S, AU - Liu,W H, AU - Fang,Y Y, AU - Xu,S B, AU - Li,J, AU - Luo,X, AU - Pan,D J, AU - Wang,M H, AU - Wang,W, Y1 - 2021/02/11/ PY - 2021/2/11/entrez PY - 2021/2/12/pubmed PY - 2021/2/24/medline KW - Alcohol KW - coffee KW - cognitive deficits KW - tea SP - e13 EP - e13 JF - Epidemiology and psychiatric sciences JO - Epidemiol Psychiatr Sci VL - 30 N2 - AIMS: Lifestyle interventions are an important and viable approach for preventing cognitive deficits. However, the results of studies on alcohol, coffee and tea consumption in relation to cognitive decline have been divergent, likely due to confounds from dose-response effects. This meta-analysis aimed to find the dose-response relationship between alcohol, coffee or tea consumption and cognitive deficits. METHODS: Prospective cohort studies or nested case-control studies in a cohort investigating the risk factors of cognitive deficits were searched in PubMed, Embase, the Cochrane and Web of Science up to 4th June 2020. Two authors searched the databases and extracted the data independently. We also assessed the quality of the studies with the Newcastle-Ottawa scale. Stata 15.0 software was used to perform model estimation and plot the linear or nonlinear dose-response relationship graphs. RESULTS: The search identified 29 prospective studies from America, Japan, China and some European countries. The dose-response relationships showed that compared to non-drinkers, low consumption (<11 g/day) of alcohol could reduce the risk of cognitive deficits or only dementias, but there was no significant effect of heavier drinking (>11 g/day). Low consumption of coffee reduced the risk of any cognitive deficit (<2.8 cups/day) or dementia (<2.3 cups/day). Green tea consumption was a significant protective factor for cognitive health (relative risk, 0.94; 95% confidence intervals, 0.92-0.97), with one cup of tea per day brings a 6% reduction in risk of cognitive deficits. CONCLUSIONS: Light consumption of alcohol (<11 g/day) and coffee (<2.8 cups/day) was associated with reduced risk of cognitive deficits. Cognitive benefits of green tea consumption increased with the daily consumption. SN - 2045-7979 UR - https://www.unboundmedicine.com/medline/citation/33568254/Alcohol_coffee_and_tea_intake_and_the_risk_of_cognitive_deficits:_a_dose_response_meta_analysis_ DB - PRIME DP - Unbound Medicine ER -