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Eicosapentaenoic Acid Is Associated with Decreased Incidence of Alzheimer's Dementia in the Oldest Old.
Nutrients. 2021 Jan 30; 13(2)N

Abstract

BACKGROUND

Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) may have different effects on cognitive health due to their anti- or pro-inflammatory properties.

METHODS

We aimed to prospectively examine the relationships between n-3 and n-6 PUFA contents in serum phospholipids with incident all-cause dementia and Alzheimer's disease dementia (AD). We included 1264 non-demented participants aged 84 ± 3 years from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe) multicenter-cohort study. We investigated whether fatty acid concentrations in serum phospholipids, especially eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), linoleic acid (LA), dihomo-γ-linolenic acid (DGLA), and arachidonic acid (AA), were associated with risk of incident all-cause dementia and AD.

RESULTS

During the follow-up window of seven years, 233 participants developed dementia. Higher concentrations of EPA were associated with a lower incidence of AD (hazard ratio (HR) 0.76 (95% CI 0.63; 0.93)). We also observed that higher concentrations of EPA were associated with a decreased risk for all-cause dementia (HR 0.76 (95% CI 0.61; 0.94)) and AD (HR 0.66 (95% CI 0.51; 0.85)) among apolipoprotein E ε4 (APOE ε4) non-carriers but not among APOE ε4 carriers. No other fatty acids were significantly associated with AD or dementia.

CONCLUSIONS

Higher concentrations of EPA were associated with a lower risk of incident AD. This further supports a beneficial role of n-3 PUFAs for cognitive health in old age.

Links

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Authors+Show Affiliations

Melo van Lent D
German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany. Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Egert S
Institute of Nutritional Medicine, University of Hohenheim, 70599 Stuttgart, Germany.
Wolfsgruber S
German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany. Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, 53127 Bonn, Germany.
Kleineidam L
Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, 53127 Bonn, Germany.
Weinhold L
Department of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, 53105 Bonn, Germany.
Wagner-Thelen H
Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, 53127 Bonn, Germany.
Maier W
Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, 53127 Bonn, Germany.
Jessen F
German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany. Department of Psychiatry, Medical Faculty, University of Cologne, 50924 Cologne, Germany.
Ramirez A
German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany. Department of Psychiatry, Medical Faculty, University of Cologne, 50924 Cologne, Germany. Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, 50937 Cologne, Germany.
Schmid M
German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany. Department of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, 53105 Bonn, Germany.
Scherer M
Department of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center, Hamburg-Eppendorf, 20146 Hamburg, Germany.
Riedel-Heller SG
Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, 04103 Leipzig, Germany.
Wagner M
German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany. Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, 53127 Bonn, Germany.

MeSH

Activities of Daily LivingAged, 80 and overAlzheimer DiseaseDementiaEicosapentaenoic AcidFatty AcidsFatty Acids, Omega-3Fatty Acids, Omega-6Fatty Acids, UnsaturatedFemaleGermanyHumansIncidenceLongitudinal StudiesMalePhospholipidsProportional Hazards ModelsProspective Studies

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

33573174

Citation

Melo van Lent, Debora, et al. "Eicosapentaenoic Acid Is Associated With Decreased Incidence of Alzheimer's Dementia in the Oldest Old." Nutrients, vol. 13, no. 2, 2021.
Melo van Lent D, Egert S, Wolfsgruber S, et al. Eicosapentaenoic Acid Is Associated with Decreased Incidence of Alzheimer's Dementia in the Oldest Old. Nutrients. 2021;13(2).
Melo van Lent, D., Egert, S., Wolfsgruber, S., Kleineidam, L., Weinhold, L., Wagner-Thelen, H., Maier, W., Jessen, F., Ramirez, A., Schmid, M., Scherer, M., Riedel-Heller, S. G., & Wagner, M. (2021). Eicosapentaenoic Acid Is Associated with Decreased Incidence of Alzheimer's Dementia in the Oldest Old. Nutrients, 13(2). https://doi.org/10.3390/nu13020461
Melo van Lent D, et al. Eicosapentaenoic Acid Is Associated With Decreased Incidence of Alzheimer's Dementia in the Oldest Old. Nutrients. 2021 Jan 30;13(2) PubMed PMID: 33573174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eicosapentaenoic Acid Is Associated with Decreased Incidence of Alzheimer's Dementia in the Oldest Old. AU - Melo van Lent,Debora, AU - Egert,Sarah, AU - Wolfsgruber,Steffen, AU - Kleineidam,Luca, AU - Weinhold,Leonie, AU - Wagner-Thelen,Holger, AU - Maier,Wolfgang, AU - Jessen,Frank, AU - Ramirez,Alfredo, AU - Schmid,Matthias, AU - Scherer,Martin, AU - Riedel-Heller,Steffi G, AU - Wagner,Michael, Y1 - 2021/01/30/ PY - 2020/12/18/received PY - 2021/01/27/revised PY - 2021/01/27/accepted PY - 2021/2/12/entrez PY - 2021/2/13/pubmed PY - 2021/9/4/medline KW - Alzheimer’s disease dementia KW - apolipoprotein E ε4 KW - dementia KW - eicosapentaenoic acid KW - fatty acids KW - oldest old KW - omega-3 JF - Nutrients JO - Nutrients VL - 13 IS - 2 N2 - BACKGROUND: Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) may have different effects on cognitive health due to their anti- or pro-inflammatory properties. METHODS: We aimed to prospectively examine the relationships between n-3 and n-6 PUFA contents in serum phospholipids with incident all-cause dementia and Alzheimer's disease dementia (AD). We included 1264 non-demented participants aged 84 ± 3 years from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe) multicenter-cohort study. We investigated whether fatty acid concentrations in serum phospholipids, especially eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), linoleic acid (LA), dihomo-γ-linolenic acid (DGLA), and arachidonic acid (AA), were associated with risk of incident all-cause dementia and AD. RESULTS: During the follow-up window of seven years, 233 participants developed dementia. Higher concentrations of EPA were associated with a lower incidence of AD (hazard ratio (HR) 0.76 (95% CI 0.63; 0.93)). We also observed that higher concentrations of EPA were associated with a decreased risk for all-cause dementia (HR 0.76 (95% CI 0.61; 0.94)) and AD (HR 0.66 (95% CI 0.51; 0.85)) among apolipoprotein E ε4 (APOE ε4) non-carriers but not among APOE ε4 carriers. No other fatty acids were significantly associated with AD or dementia. CONCLUSIONS: Higher concentrations of EPA were associated with a lower risk of incident AD. This further supports a beneficial role of n-3 PUFAs for cognitive health in old age. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/33573174/Eicosapentaenoic_Acid_Is_Associated_with_Decreased_Incidence_of_Alzheimer's_Dementia_in_the_Oldest_Old_ DB - PRIME DP - Unbound Medicine ER -