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Improved lactose digestion during pregnancy: a case of physiologic adaptation?
Obstet Gynecol. 1988 May; 71(5):697-700.OG

Abstract

Loss of intestinal lactase activity among adults could theoretically limit milk consumption and hence dietary availability of calcium during pregnancy. The present study sought to define, using breath hydrogen (H2) production as an index of incomplete carbohydrate absorption, the prevalence during pregnancy of lactose maldigestion of 360 mL of milk (18 g of lactose), and to determine whether lactose digestion improved as pregnancy advanced. The prevalence of lactose maldigestion among 114 pregnant women tested before the 15th week of gestation was 54%. By term, 44% of those originally classified as maldigesters had become digesters. There was a significant reduction in the four-hour sum of the changes in breath H2 concentration from the period before 15 weeks (116.6 +/- 9.6 ppm) to the time after 36 weeks (54.4 +/- 7.3 ppm; P less than .01). This apparent adaptive improvement in intestinal handling of milk lactose during gestation has implications for calcium intake and absorption.

Authors+Show Affiliations

Prevention Research Program, National Institute of Child Health and Human Development, Bethesda, Maryland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3357657

Citation

Villar, J, et al. "Improved Lactose Digestion During Pregnancy: a Case of Physiologic Adaptation?" Obstetrics and Gynecology, vol. 71, no. 5, 1988, pp. 697-700.
Villar J, Kestler E, Castillo P, et al. Improved lactose digestion during pregnancy: a case of physiologic adaptation? Obstet Gynecol. 1988;71(5):697-700.
Villar, J., Kestler, E., Castillo, P., Juarez, A., Menendez, R., & Solomons, N. W. (1988). Improved lactose digestion during pregnancy: a case of physiologic adaptation? Obstetrics and Gynecology, 71(5), 697-700.
Villar J, et al. Improved Lactose Digestion During Pregnancy: a Case of Physiologic Adaptation. Obstet Gynecol. 1988;71(5):697-700. PubMed PMID: 3357657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improved lactose digestion during pregnancy: a case of physiologic adaptation? AU - Villar,J, AU - Kestler,E, AU - Castillo,P, AU - Juarez,A, AU - Menendez,R, AU - Solomons,N W, PY - 1988/5/1/pubmed PY - 1988/5/1/medline PY - 1988/5/1/entrez SP - 697 EP - 700 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 71 IS - 5 N2 - Loss of intestinal lactase activity among adults could theoretically limit milk consumption and hence dietary availability of calcium during pregnancy. The present study sought to define, using breath hydrogen (H2) production as an index of incomplete carbohydrate absorption, the prevalence during pregnancy of lactose maldigestion of 360 mL of milk (18 g of lactose), and to determine whether lactose digestion improved as pregnancy advanced. The prevalence of lactose maldigestion among 114 pregnant women tested before the 15th week of gestation was 54%. By term, 44% of those originally classified as maldigesters had become digesters. There was a significant reduction in the four-hour sum of the changes in breath H2 concentration from the period before 15 weeks (116.6 +/- 9.6 ppm) to the time after 36 weeks (54.4 +/- 7.3 ppm; P less than .01). This apparent adaptive improvement in intestinal handling of milk lactose during gestation has implications for calcium intake and absorption. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/3357657/Improved_lactose_digestion_during_pregnancy:_a_case_of_physiologic_adaptation L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=3357657.ui DB - PRIME DP - Unbound Medicine ER -