Citation
Daniele, Simona, et al. "Α-Synuclein Heteromers in Red Blood Cells of Alzheimer's Disease and Lewy Body Dementia Patients." Journal of Alzheimer's Disease : JAD, vol. 80, no. 2, 2021, pp. 885-893.
Daniele S, Baldacci F, Piccarducci R, et al. Α-Synuclein Heteromers in Red Blood Cells of Alzheimer's Disease and Lewy Body Dementia Patients. J Alzheimers Dis. 2021;80(2):885-893.
Daniele, S., Baldacci, F., Piccarducci, R., Palermo, G., Giampietri, L., Manca, M. L., Pietrobono, D., Frosini, D., Nicoletti, V., Tognoni, G., Giorgi, F. S., Lo Gerfo, A., Petrozzi, L., Cavallini, C., Franzoni, F., Ceravolo, R., Siciliano, G., Trincavelli, M. L., Martini, C., & Bonuccelli, U. (2021). Α-Synuclein Heteromers in Red Blood Cells of Alzheimer's Disease and Lewy Body Dementia Patients. Journal of Alzheimer's Disease : JAD, 80(2), 885-893. https://doi.org/10.3233/JAD-201038
Daniele S, et al. Α-Synuclein Heteromers in Red Blood Cells of Alzheimer's Disease and Lewy Body Dementia Patients. J Alzheimers Dis. 2021;80(2):885-893. PubMed PMID: 33579836.
TY - JOUR
T1 - α-Synuclein Heteromers in Red Blood Cells of Alzheimer's Disease and Lewy Body Dementia Patients.
AU - Daniele,Simona,
AU - Baldacci,Filippo,
AU - Piccarducci,Rebecca,
AU - Palermo,Giovanni,
AU - Giampietri,Linda,
AU - Manca,Maria Laura,
AU - Pietrobono,Deborah,
AU - Frosini,Daniela,
AU - Nicoletti,Valentina,
AU - Tognoni,Gloria,
AU - Giorgi,Filippo Sean,
AU - Lo Gerfo,Annalisa,
AU - Petrozzi,Lucia,
AU - Cavallini,Chiara,
AU - Franzoni,Ferdinando,
AU - Ceravolo,Roberto,
AU - Siciliano,Gabriele,
AU - Trincavelli,Maria Letizia,
AU - Martini,Claudia,
AU - Bonuccelli,Ubaldo,
PY - 2021/2/14/pubmed
PY - 2021/9/7/medline
PY - 2021/2/13/entrez
KW - Alzheimer’s disease
KW - Lewy body dementia
KW - amyloid-β
KW - red blood cells
KW - α-Synuclein
SP - 885
EP - 893
JF - Journal of Alzheimer's disease : JAD
JO - J Alzheimers Dis
VL - 80
IS - 2
N2 - BACKGROUND: Red blood cells (RBCs) contain the majority of α-synuclein (α-syn) in blood, representing an interesting model for studying the peripheral pathological alterations proved in neurodegeneration. OBJECTIVE: The current study aimed to investigate the diagnostic value of total α-syn, amyloid-β (Aβ1-42), tau, and their heteroaggregates in RBCs of Lewy body dementia (LBD) and Alzheimer's disease (AD) patients compared to healthy controls (HC). METHODS: By the use of enzyme-linked immunosorbent assays, RBCs concentrations of total α-syn, Aβ1-42, tau, and their heteroaggregates (α-syn/Aβ1-42 and α-syn/tau) were measured in 27 individuals with LBD (Parkinson's disease dementia, n = 17; dementia with Lewy bodies, n = 10), 51 individuals with AD (AD dementia, n = 37; prodromal AD, n = 14), and HC (n = 60). RESULTS: The total α-syn and tau concentrations as well as α-syn/tau heterodimers were significantly lower in the LBD group and the AD group compared with HC, whereas α-syn/Aβ1-42 concentrations were significantly lower in the AD dementia group only. RBC α-syn/tau heterodimers had a higher diagnostic accuracy for differentiating patients with LBD versus HC (AUROC = 0.80). CONCLUSION: RBC α-syn heteromers may be useful for differentiating between neurodegenerative dementias (LBD and AD) and HC. In particular, RBC α-syn/tau heterodimers have demonstrated good diagnostic accuracy for differentiating LBD from HC. However, they are not consistently different between LBD and AD. Our findings also suggest that α-syn, Aβ1-42, and tau interact in vivo to promote the aggregation and accumulation of each other.
SN - 1875-8908
UR - https://www.unboundmedicine.com/medline/citation/33579836/α_Synuclein_Heteromers_in_Red_Blood_Cells_of_Alzheimer's_Disease_and_Lewy_Body_Dementia_Patients_
DB - PRIME
DP - Unbound Medicine
ER -
