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The effect of soy isoflavones and soy isoflavones plus soy protein on serum concentration of tumor necrosis factor-α? A systematic review and meta-analysis of randomized controlled trials.
Phytother Res. 2021 Jul; 35(7):3575-3589.PR

Abstract

In this study, we summarized the effect of soy isoflavones and soy isoflavones plus soy protein on serum concentration of tumor necrosis factor-alpha (TNF-α) among adult participants. We systematically searched Scopus, ISI Web of Science, Cochrane Library, PubMed, and clinicaltrials.gov for articles published up to May 2020. Effect size was calculated by mean change from baseline of TNF-α concentrations and its standard deviation (SD) for intervention and comparison groups. If the heterogeneity test was statistically significant, DerSimonian and Laird random effects model was used to estimate the summary of the overall effects and its heterogeneity. Nineteen and fourteen randomized clinical trials were included in our systematic review and meta-analysis, respectively. The result of overall effect size indicated a non-significant effect in serum concentration of TNF-α following soy isoflavones intake (WMD = 0.2 pg/ml, 95% CI: -0.13, 0.53; p = .226) and the combination of soy isoflavones and soy protein intake (WMD = 0.02 pg/ml, 95% CI: -0.02, 0.06; p = .286). Subgroup analyses revealed no significant change in circulatory levels of TNF-α following soy isoflavones plus soy protein intake. In conclusion, the present systematic review and meta-analysis found insufficient evidence that soy isoflavones or the combination of soy isoflavones and soy protein significantly reduce serum concentration of TNF-α.

Authors+Show Affiliations

Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran. Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. Ageing Clinical and Experimental Research Team, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran. Department of Epidemiology and Biostatistics, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

33586244

Citation

Hariri, Mitra, et al. "The Effect of Soy Isoflavones and Soy Isoflavones Plus Soy Protein On Serum Concentration of Tumor Necrosis Factor-α? a Systematic Review and Meta-analysis of Randomized Controlled Trials." Phytotherapy Research : PTR, vol. 35, no. 7, 2021, pp. 3575-3589.
Hariri M, Baradaran HR, Gholami A. The effect of soy isoflavones and soy isoflavones plus soy protein on serum concentration of tumor necrosis factor-α? A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2021;35(7):3575-3589.
Hariri, M., Baradaran, H. R., & Gholami, A. (2021). The effect of soy isoflavones and soy isoflavones plus soy protein on serum concentration of tumor necrosis factor-α? A systematic review and meta-analysis of randomized controlled trials. Phytotherapy Research : PTR, 35(7), 3575-3589. https://doi.org/10.1002/ptr.7047
Hariri M, Baradaran HR, Gholami A. The Effect of Soy Isoflavones and Soy Isoflavones Plus Soy Protein On Serum Concentration of Tumor Necrosis Factor-α? a Systematic Review and Meta-analysis of Randomized Controlled Trials. Phytother Res. 2021;35(7):3575-3589. PubMed PMID: 33586244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of soy isoflavones and soy isoflavones plus soy protein on serum concentration of tumor necrosis factor-α? A systematic review and meta-analysis of randomized controlled trials. AU - Hariri,Mitra, AU - Baradaran,Hamid Reza, AU - Gholami,Ali, Y1 - 2021/02/14/ PY - 2020/12/28/revised PY - 2020/08/05/received PY - 2021/01/27/accepted PY - 2021/2/16/pubmed PY - 2021/9/29/medline PY - 2021/2/15/entrez KW - TNF-α KW - meta-analysis KW - soy isoflavones KW - soy protein KW - systematic review KW - tumor necrosis factor-alpha SP - 3575 EP - 3589 JF - Phytotherapy research : PTR JO - Phytother Res VL - 35 IS - 7 N2 - In this study, we summarized the effect of soy isoflavones and soy isoflavones plus soy protein on serum concentration of tumor necrosis factor-alpha (TNF-α) among adult participants. We systematically searched Scopus, ISI Web of Science, Cochrane Library, PubMed, and clinicaltrials.gov for articles published up to May 2020. Effect size was calculated by mean change from baseline of TNF-α concentrations and its standard deviation (SD) for intervention and comparison groups. If the heterogeneity test was statistically significant, DerSimonian and Laird random effects model was used to estimate the summary of the overall effects and its heterogeneity. Nineteen and fourteen randomized clinical trials were included in our systematic review and meta-analysis, respectively. The result of overall effect size indicated a non-significant effect in serum concentration of TNF-α following soy isoflavones intake (WMD = 0.2 pg/ml, 95% CI: -0.13, 0.53; p = .226) and the combination of soy isoflavones and soy protein intake (WMD = 0.02 pg/ml, 95% CI: -0.02, 0.06; p = .286). Subgroup analyses revealed no significant change in circulatory levels of TNF-α following soy isoflavones plus soy protein intake. In conclusion, the present systematic review and meta-analysis found insufficient evidence that soy isoflavones or the combination of soy isoflavones and soy protein significantly reduce serum concentration of TNF-α. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/33586244/The_effect_of_soy_isoflavones_and_soy_isoflavones_plus_soy_protein_on_serum_concentration_of_tumor_necrosis_factor_α_A_systematic_review_and_meta_analysis_of_randomized_controlled_trials_ L2 - https://doi.org/10.1002/ptr.7047 DB - PRIME DP - Unbound Medicine ER -