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A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults.
J Ethnopharmacol. 2021 May 23; 272:113929.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Ashwagandha is a reputed herb in traditional Ayurveda, used for various ailments and improving general well-being. Improved cardiorespiratory endurance can aid in attaining better physiological, metabolic, and functional abilities in humans. According to Ayurveda, Ashwagandha has such potential to improve human health.

AIM OF THE STUDY

This study aimed to evaluate the efficacy and safety of Ashwagandha root extract in enhancing cardiorespiratory endurance in healthy athletic adults.

MATERIALS AND METHODS

Fifty healthy athletic adults were selected randomly and equally allocated to Ashwagandha and placebo groups. The Ashwagandha group received 300 mg of Ashwagandha root extract capsules, twice daily, for 8-weeks. Cardiorespiratory endurance was assessed by measuring the maximum aerobic capacity (VO2 max). Estimation of stress management was done through Total Quality Recovery Scores (TQR), Recovery-Stress Questionnaire for Athletes (RESTQ), and Daily Analysis of Life Demands for Athletes (DALDA) questionnaires along with the antioxidant level measurement.

RESULTS

At the end of the study, a statistically significant improvement in VO2 max outcome was observed in the Ashwagandha group when compared to the placebo group (P = 0.0074). The subjects in the Ashwagandha group also displayed a statistically significant increase at the end of the study when compared to the baseline (P < 0.0001). Significantly improved TQR scores were observed in the Ashwagandha group members compared to their placebo counterparts (P < 0.0001). DALDA questionnaire analysis in the Ashwagandha group was found statistically significant (P < 0.0001) compared to the placebo group. RESTQ assessment also yielded better outcomes, especially for fatigue recovery (P < 0.0001), lack of energy (P < 0.0001), and fitness analysis (P < 0.0001). The enhanced antioxidant level was significant (P < 0.0001) in the Ashwagandha group.

CONCLUSION

The present findings suggest that Ashwagandha root extract can successfully enhance cardiorespiratory endurance and improve the quality of life in healthy athletic adults. No adverse events were reported by any of the subjects in this study.

Authors+Show Affiliations

OM Research Centre, SA-17/3, P-4, Sri Krishna Nagar, Paharia Ghazipur Road, Varanasi, 221002, Uttar Pradesh, India. Electronic address: drtiwari.bds@gmail.com.M V Hospital and Research Centre, 314/30 Mirza Mandi, Post Office, Chowk, Lucknow, 226003, Uttar Pradesh, India.Rajajipuram, Lucknow, 226017, Uttar Pradesh, India.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

33600918

Citation

Tiwari, Shashank, et al. "A Double-blind, Randomized, Placebo-controlled Trial On the Effect of Ashwagandha (Withania Somnifera Dunal.) Root Extract in Improving Cardiorespiratory Endurance and Recovery in Healthy Athletic Adults." Journal of Ethnopharmacology, vol. 272, 2021, p. 113929.
Tiwari S, Gupta SK, Pathak AK. A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults. J Ethnopharmacol. 2021;272:113929.
Tiwari, S., Gupta, S. K., & Pathak, A. K. (2021). A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults. Journal of Ethnopharmacology, 272, 113929. https://doi.org/10.1016/j.jep.2021.113929
Tiwari S, Gupta SK, Pathak AK. A Double-blind, Randomized, Placebo-controlled Trial On the Effect of Ashwagandha (Withania Somnifera Dunal.) Root Extract in Improving Cardiorespiratory Endurance and Recovery in Healthy Athletic Adults. J Ethnopharmacol. 2021 May 23;272:113929. PubMed PMID: 33600918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) root extract in improving cardiorespiratory endurance and recovery in healthy athletic adults. AU - Tiwari,Shashank, AU - Gupta,Sandeep Kumar, AU - Pathak,Anklesh Kumar, Y1 - 2021/02/15/ PY - 2019/11/01/received PY - 2020/11/21/revised PY - 2021/02/12/accepted PY - 2021/2/19/pubmed PY - 2021/9/15/medline PY - 2021/2/18/entrez KW - Antioxidant assay KW - Ashwagandha KW - Cardiorespiratory endurance KW - DALDA KW - RESTQ-Sport KW - TQR KW - VO2 max SP - 113929 EP - 113929 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 272 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Ashwagandha is a reputed herb in traditional Ayurveda, used for various ailments and improving general well-being. Improved cardiorespiratory endurance can aid in attaining better physiological, metabolic, and functional abilities in humans. According to Ayurveda, Ashwagandha has such potential to improve human health. AIM OF THE STUDY: This study aimed to evaluate the efficacy and safety of Ashwagandha root extract in enhancing cardiorespiratory endurance in healthy athletic adults. MATERIALS AND METHODS: Fifty healthy athletic adults were selected randomly and equally allocated to Ashwagandha and placebo groups. The Ashwagandha group received 300 mg of Ashwagandha root extract capsules, twice daily, for 8-weeks. Cardiorespiratory endurance was assessed by measuring the maximum aerobic capacity (VO2 max). Estimation of stress management was done through Total Quality Recovery Scores (TQR), Recovery-Stress Questionnaire for Athletes (RESTQ), and Daily Analysis of Life Demands for Athletes (DALDA) questionnaires along with the antioxidant level measurement. RESULTS: At the end of the study, a statistically significant improvement in VO2 max outcome was observed in the Ashwagandha group when compared to the placebo group (P = 0.0074). The subjects in the Ashwagandha group also displayed a statistically significant increase at the end of the study when compared to the baseline (P < 0.0001). Significantly improved TQR scores were observed in the Ashwagandha group members compared to their placebo counterparts (P < 0.0001). DALDA questionnaire analysis in the Ashwagandha group was found statistically significant (P < 0.0001) compared to the placebo group. RESTQ assessment also yielded better outcomes, especially for fatigue recovery (P < 0.0001), lack of energy (P < 0.0001), and fitness analysis (P < 0.0001). The enhanced antioxidant level was significant (P < 0.0001) in the Ashwagandha group. CONCLUSION: The present findings suggest that Ashwagandha root extract can successfully enhance cardiorespiratory endurance and improve the quality of life in healthy athletic adults. No adverse events were reported by any of the subjects in this study. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/33600918/A_double_blind_randomized_placebo_controlled_trial_on_the_effect_of_Ashwagandha__Withania_somnifera_dunal___root_extract_in_improving_cardiorespiratory_endurance_and_recovery_in_healthy_athletic_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(21)00155-0 DB - PRIME DP - Unbound Medicine ER -