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Features of patients that died for COVID-19 in a hospital in the south of Mexico: A observational cohort study.
PLoS One. 2021; 16(2):e0245394.Plos

Abstract

BACKGROUND

Due to the wide spread of SARS-CoV2 around the world, the risk of death in individuals with metabolic comorbidities has dangerously increased. Mexico has a high number of infected individuals and deaths by COVID-19 as well as an important burden of metabolic diseases; nevertheless, reports about features of Mexican individuals with COVID-19 are scarce. The aim of this study was to evaluate demographic features, clinical characteristics and the pharmacological treatment of individuals who died by COVID-19 in the south of Mexico.

METHODS

We performed an observational study including the information of 185 deceased individuals with confirmed diagnoses of COVID-19. Data were retrieved from medical records. Categorical data were expressed as proportions (%) and numerical data were expressed as mean ± standard deviation. Comorbidities and overlapping symptoms were plotted as Venn diagrams. Drug clusters were plotted as dendrograms.

RESULTS

The mean age was 59.53 years. There was a male predominance (60.1%). The mean hospital stay was 4.75 ± 4.43 days. The most frequent symptoms were dyspnea (88.77%), fever (71.42%) and dry cough (64.28%). Present comorbidities included diabetes (60.63%), hypertension (59.57%) and obesity (43.61%). The main drugs used for treating COVID-19 were azithromycin (60.6%), hydroxychloroquine (53.0%) and oseltamivir (27.3%).

CONCLUSIONS

Mexican individuals who died of COVID-19 had shorter hospital stays, higher frequency of shortness of breath, and higher prevalence of diabetes than individuals from other countries. Also, there was a high frequency of off-label use of drugs for their treatment.

Authors+Show Affiliations

Secretaría de Salud, Hospital de Alta Especialidad Dr. Juan Graham Casasús, Villahermosa, Tabasco, México.División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco, México.División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco, México.División Académica Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tabasco, México.Secretaría de Salud, Hospital de Alta Especialidad Dr. Juan Graham Casasús, Villahermosa, Tabasco, México.Secretaría de Salud, Hospital de Alta Especialidad Dr. Juan Graham Casasús, Villahermosa, Tabasco, México.División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco, México.División Académica de Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Tabasco, México.Secretaría de Salud, Hospital de Alta Especialidad Dr. Juan Graham Casasús, Villahermosa, Tabasco, México.Secretaría de Salud, Hospital de Alta Especialidad Dr. Juan Graham Casasús, Villahermosa, Tabasco, México.Secretaría de Salud, Hospital de Alta Especialidad Dr. Juan Graham Casasús, Villahermosa, Tabasco, México.División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco, México.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

33606711

Citation

Ruíz-Quiñonez, Jesús Arturo, et al. "Features of Patients That Died for COVID-19 in a Hospital in the South of Mexico: a Observational Cohort Study." PloS One, vol. 16, no. 2, 2021, pp. e0245394.
Ruíz-Quiñonez JA, Guzmán-Priego CG, Nolasco-Rosales GA, et al. Features of patients that died for COVID-19 in a hospital in the south of Mexico: A observational cohort study. PLoS One. 2021;16(2):e0245394.
Ruíz-Quiñonez, J. A., Guzmán-Priego, C. G., Nolasco-Rosales, G. A., Tovilla-Zarate, C. A., Flores-Barrientos, O. I., Narváez-Osorio, V., Baeza-Flores, G. D. C., Gonzalez-Castro, T. B., López-Brito, C. R., Denis-García, C. A., Pérez-García, A., & Juárez-Rojop, I. E. (2021). Features of patients that died for COVID-19 in a hospital in the south of Mexico: A observational cohort study. PloS One, 16(2), e0245394. https://doi.org/10.1371/journal.pone.0245394
Ruíz-Quiñonez JA, et al. Features of Patients That Died for COVID-19 in a Hospital in the South of Mexico: a Observational Cohort Study. PLoS One. 2021;16(2):e0245394. PubMed PMID: 33606711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Features of patients that died for COVID-19 in a hospital in the south of Mexico: A observational cohort study. AU - Ruíz-Quiñonez,Jesús Arturo, AU - Guzmán-Priego,Crystell Guadalupe, AU - Nolasco-Rosales,Germán Alberto, AU - Tovilla-Zarate,Carlos Alfonso, AU - Flores-Barrientos,Oscar Israel, AU - Narváez-Osorio,Víctor, AU - Baeza-Flores,Guadalupe Del Carmen, AU - Gonzalez-Castro,Thelma Beatriz, AU - López-Brito,Carlos Ramón, AU - Denis-García,Carlos Alberto, AU - Pérez-García,Agustín, AU - Juárez-Rojop,Isela Esther, Y1 - 2021/02/19/ PY - 2020/09/16/received PY - 2020/12/17/accepted PY - 2021/2/19/entrez PY - 2021/2/20/pubmed PY - 2021/3/2/medline SP - e0245394 EP - e0245394 JF - PloS one JO - PLoS One VL - 16 IS - 2 N2 - BACKGROUND: Due to the wide spread of SARS-CoV2 around the world, the risk of death in individuals with metabolic comorbidities has dangerously increased. Mexico has a high number of infected individuals and deaths by COVID-19 as well as an important burden of metabolic diseases; nevertheless, reports about features of Mexican individuals with COVID-19 are scarce. The aim of this study was to evaluate demographic features, clinical characteristics and the pharmacological treatment of individuals who died by COVID-19 in the south of Mexico. METHODS: We performed an observational study including the information of 185 deceased individuals with confirmed diagnoses of COVID-19. Data were retrieved from medical records. Categorical data were expressed as proportions (%) and numerical data were expressed as mean ± standard deviation. Comorbidities and overlapping symptoms were plotted as Venn diagrams. Drug clusters were plotted as dendrograms. RESULTS: The mean age was 59.53 years. There was a male predominance (60.1%). The mean hospital stay was 4.75 ± 4.43 days. The most frequent symptoms were dyspnea (88.77%), fever (71.42%) and dry cough (64.28%). Present comorbidities included diabetes (60.63%), hypertension (59.57%) and obesity (43.61%). The main drugs used for treating COVID-19 were azithromycin (60.6%), hydroxychloroquine (53.0%) and oseltamivir (27.3%). CONCLUSIONS: Mexican individuals who died of COVID-19 had shorter hospital stays, higher frequency of shortness of breath, and higher prevalence of diabetes than individuals from other countries. Also, there was a high frequency of off-label use of drugs for their treatment. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/33606711/Features_of_patients_that_died_for_COVID-19_in_a_hospital_in_the_south_of_Mexico:_A_observational_cohort_study. L2 - https://dx.plos.org/10.1371/journal.pone.0245394 DB - PRIME DP - Unbound Medicine ER -