Tags

Type your tag names separated by a space and hit enter

Andrographis paniculata (Burm.f.) Nees and its major constituent andrographolide as potential antiviral agents.
J Ethnopharmacol. 2021 May 23; 272:113954.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Andrographis paniculata (Burm.f.) Nees is widely used all over the world, especially in subtropical regions such as India, Thailand, Vietnam, and China. As a traditional folk Chinese medicine, A. paniculata has been extensively utilized for the treatment of cold, fever, sore throat, cough, carbuncle, and sores, and it is commonly employed for 'clearing heat and resolving toxicity'. Typical symptoms of 'heat and toxicity' include swollen, painful gums, associated with virus-related diseases to a great extent. In vivo and in vitro experiments have demonstrated the potential antiviral properties of A. paniculata and identified its major active constituents against various viruses.

AIM OF THE STUDY

This review focuses on connecting the traditional 'clearing heat and resolving toxicity' effect to compelling recent research advances on the antiviral effects of A. paniculata, explaining its major antiviral mechanisms, and assessing the shortcomings of existing work. Besides, ethnobotany, ethnopharmacological uses, phytochemicals, and toxicology of A. paniculata have been researched.

MATERIALS AND METHODS

The information about A. paniculata was collected from various sources including classic books about Chinese herbal medicine, and scientific databases including WEB OF SCIENCE, PubMed, ScienceDirect, Springer, ACS, SCOPUS, CNKI, CSTJ, and WANFANG.

RESULTS

In this review, the underlying mechanisms of antiviral effect mainly involve the regulation of virus entry, gene replication, and synthesis of functionally mature proteins. Also, A. paniculata is a safe agent without obvious toxicity. Ethnobotany, ethnopharmacological uses, and chemical constituents have been summarized.

CONCLUSION

Andrographis paniculata (Burm.f.) Nees could be used as an imperative complementary medicine for the treatment of diverse virus infection, efforts should be made to gain insights into its antiviral properties.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Jiang M
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, 999078, China. Electronic address: maoyuanjiangsoc@126.com.
Sheng F
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, 999078, China. Electronic address: sophia880728@126.com.
Zhang Z
Pharmacy College, Chengdu University of Traditional Chinese Medicine, State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu, 611137, China. Electronic address: zhangzhendr@126.com.
Ma X
Pharmacy College, Chengdu University of Traditional Chinese Medicine, State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu, 611137, China. Electronic address: 344783228@qq.com.
Gao T
Medical College, Qingdao Binhai University, Qingdao, 266555, China. Electronic address: gaotianhui1349@163.com.
Fu C
Pharmacy College, Chengdu University of Traditional Chinese Medicine, State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu, 611137, China. Electronic address: chaomeifu@126.com.
Li P
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, 999078, China. Electronic address: pli1978@hotmail.com.

MeSH

AndrographisAnimalsAntiviral AgentsAsiaDiterpenesEthnopharmacologyHumansPhytochemicalsPlant Extracts

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33610706

Citation

Jiang, Maoyuan, et al. "Andrographis Paniculata (Burm.f.) Nees and Its Major Constituent Andrographolide as Potential Antiviral Agents." Journal of Ethnopharmacology, vol. 272, 2021, p. 113954.
Jiang M, Sheng F, Zhang Z, et al. Andrographis paniculata (Burm.f.) Nees and its major constituent andrographolide as potential antiviral agents. J Ethnopharmacol. 2021;272:113954.
Jiang, M., Sheng, F., Zhang, Z., Ma, X., Gao, T., Fu, C., & Li, P. (2021). Andrographis paniculata (Burm.f.) Nees and its major constituent andrographolide as potential antiviral agents. Journal of Ethnopharmacology, 272, 113954. https://doi.org/10.1016/j.jep.2021.113954
Jiang M, et al. Andrographis Paniculata (Burm.f.) Nees and Its Major Constituent Andrographolide as Potential Antiviral Agents. J Ethnopharmacol. 2021 May 23;272:113954. PubMed PMID: 33610706.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Andrographis paniculata (Burm.f.) Nees and its major constituent andrographolide as potential antiviral agents. AU - Jiang,Maoyuan, AU - Sheng,Feiya, AU - Zhang,Zhen, AU - Ma,Xiao, AU - Gao,Tianhui, AU - Fu,Chaomei, AU - Li,Peng, Y1 - 2021/02/18/ PY - 2020/11/05/received PY - 2021/02/04/revised PY - 2021/02/14/accepted PY - 2021/2/22/pubmed PY - 2021/9/15/medline PY - 2021/2/21/entrez KW - A. paniculata KW - Antiviral property KW - Ethnobotany KW - Ethnopharmacological uses KW - Phytochemicals KW - Toxicity SP - 113954 EP - 113954 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 272 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Andrographis paniculata (Burm.f.) Nees is widely used all over the world, especially in subtropical regions such as India, Thailand, Vietnam, and China. As a traditional folk Chinese medicine, A. paniculata has been extensively utilized for the treatment of cold, fever, sore throat, cough, carbuncle, and sores, and it is commonly employed for 'clearing heat and resolving toxicity'. Typical symptoms of 'heat and toxicity' include swollen, painful gums, associated with virus-related diseases to a great extent. In vivo and in vitro experiments have demonstrated the potential antiviral properties of A. paniculata and identified its major active constituents against various viruses. AIM OF THE STUDY: This review focuses on connecting the traditional 'clearing heat and resolving toxicity' effect to compelling recent research advances on the antiviral effects of A. paniculata, explaining its major antiviral mechanisms, and assessing the shortcomings of existing work. Besides, ethnobotany, ethnopharmacological uses, phytochemicals, and toxicology of A. paniculata have been researched. MATERIALS AND METHODS: The information about A. paniculata was collected from various sources including classic books about Chinese herbal medicine, and scientific databases including WEB OF SCIENCE, PubMed, ScienceDirect, Springer, ACS, SCOPUS, CNKI, CSTJ, and WANFANG. RESULTS: In this review, the underlying mechanisms of antiviral effect mainly involve the regulation of virus entry, gene replication, and synthesis of functionally mature proteins. Also, A. paniculata is a safe agent without obvious toxicity. Ethnobotany, ethnopharmacological uses, and chemical constituents have been summarized. CONCLUSION: Andrographis paniculata (Burm.f.) Nees could be used as an imperative complementary medicine for the treatment of diverse virus infection, efforts should be made to gain insights into its antiviral properties. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/33610706/Andrographis_paniculata__Burm_f___Nees_and_its_major_constituent_andrographolide_as_potential_antiviral_agents_ DB - PRIME DP - Unbound Medicine ER -