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Update on SARS-CoV-2 infection in children.
Paediatr Int Child Health. 2021 02; 41(1):56-64.PI

Abstract

Despite the worldwide spread of SARS-CoV-2 infection (COVID-19), knowledge of the different clinical presentations, ways of transmission, severity and prognosis in children and adolescents is limited. An increasing number of reports describe some of these characteristics in this age range. A non-systematic review was undertaken using MEDLINE (PubMed), LILACS (VHL), Scopus, Web of Science, Cochrane and CAPES Portal databases from 1 January until 30 September 2020 [103] with the search terms SARS-CoV-2, COVID-19, child, children, youth, adolescent and newborn to identify the more recent clinical aspects of SARS-CoV-2 infection in children. In general, SARS-CoV-2 infection in children tends to be asymptomatic or to have mild or moderate signs, and most young ones are infected by family members. Recent reports offer new insights into the disease. Current evidence on SARS-CoV-2 infection in children and adolescents is presented, especially concerning the clinical presentation, imaging and uncommon severe forms of the disease, particularly the COVID-19-associated multisystem inflammatory syndrome. The impact of COVID-19 infection in the perinatal period is described in detail. Knowledge of the various clinical presentations of SARS-CoV-2 in children and adolescents allows the paediatrician to diagnose earlier, monitor warnings signs, implement treatment and, especially, establish preventive measures.Abbreviations : ACE-2, angiotensin-converting enzyme 2; ARDS, acute respiratory distress syndrome; ARF, acute rheumatic fever; CAA, coronary artery aneurysms; CK-MB, creatine kinase-MB; COVID-19, coronavirus disease-2019; HLA, specific human leucocyte antigen; IPC, infection prevention and control; IVIG, intravenous immunoglobulin; KD, Kawasaki disease; MIS-C, COVID-19-associated multisystem inflammatory syndrome; RNA, ribonucleic acid; RT-PCR, reserve transcription-polymerase chain reaction; SARS-CoV-2, severe acute respiratory syndrome coronavirus-2; TCT, thoracic computed tomography; TSS, toxic shock syndrome; WHO, World Health Organization.

Authors+Show Affiliations

Department of Pediatrics, Institute of Childcare and Pediatrics Martagão Gesteira, Universidade Federal do Rio de Janeiro, Rio De Janeiro, Brazil.Department of Pediatrics, Intituto d'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, Brazil.Department of Pediatrics, School of Medicine, Universidade Federal do Rio de Janeiro, Rio De Janeiro, Brazil.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33616026

Citation

Martins, Marlos Melo, et al. "Update On SARS-CoV-2 Infection in Children." Paediatrics and International Child Health, vol. 41, no. 1, 2021, pp. 56-64.
Martins MM, Prata-Barbosa A, da Cunha AJLA. Update on SARS-CoV-2 infection in children. Paediatr Int Child Health. 2021;41(1):56-64.
Martins, M. M., Prata-Barbosa, A., & da Cunha, A. J. L. A. (2021). Update on SARS-CoV-2 infection in children. Paediatrics and International Child Health, 41(1), 56-64. https://doi.org/10.1080/20469047.2021.1888026
Martins MM, Prata-Barbosa A, da Cunha AJLA. Update On SARS-CoV-2 Infection in Children. Paediatr Int Child Health. 2021;41(1):56-64. PubMed PMID: 33616026.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Update on SARS-CoV-2 infection in children. AU - Martins,Marlos Melo, AU - Prata-Barbosa,Arnaldo, AU - da Cunha,Antônio José Ledo Alves, Y1 - 2021/02/22/ PY - 2021/2/23/pubmed PY - 2021/4/28/medline PY - 2021/2/22/entrez KW - Covid-19 KW - SARS-CoV-2 KW - adolescents KW - children KW - newborn SP - 56 EP - 64 JF - Paediatrics and international child health JO - Paediatr Int Child Health VL - 41 IS - 1 N2 - Despite the worldwide spread of SARS-CoV-2 infection (COVID-19), knowledge of the different clinical presentations, ways of transmission, severity and prognosis in children and adolescents is limited. An increasing number of reports describe some of these characteristics in this age range. A non-systematic review was undertaken using MEDLINE (PubMed), LILACS (VHL), Scopus, Web of Science, Cochrane and CAPES Portal databases from 1 January until 30 September 2020 [103] with the search terms SARS-CoV-2, COVID-19, child, children, youth, adolescent and newborn to identify the more recent clinical aspects of SARS-CoV-2 infection in children. In general, SARS-CoV-2 infection in children tends to be asymptomatic or to have mild or moderate signs, and most young ones are infected by family members. Recent reports offer new insights into the disease. Current evidence on SARS-CoV-2 infection in children and adolescents is presented, especially concerning the clinical presentation, imaging and uncommon severe forms of the disease, particularly the COVID-19-associated multisystem inflammatory syndrome. The impact of COVID-19 infection in the perinatal period is described in detail. Knowledge of the various clinical presentations of SARS-CoV-2 in children and adolescents allows the paediatrician to diagnose earlier, monitor warnings signs, implement treatment and, especially, establish preventive measures.Abbreviations : ACE-2, angiotensin-converting enzyme 2; ARDS, acute respiratory distress syndrome; ARF, acute rheumatic fever; CAA, coronary artery aneurysms; CK-MB, creatine kinase-MB; COVID-19, coronavirus disease-2019; HLA, specific human leucocyte antigen; IPC, infection prevention and control; IVIG, intravenous immunoglobulin; KD, Kawasaki disease; MIS-C, COVID-19-associated multisystem inflammatory syndrome; RNA, ribonucleic acid; RT-PCR, reserve transcription-polymerase chain reaction; SARS-CoV-2, severe acute respiratory syndrome coronavirus-2; TCT, thoracic computed tomography; TSS, toxic shock syndrome; WHO, World Health Organization. SN - 2046-9055 UR - https://www.unboundmedicine.com/medline/citation/33616026/Update_on_SARS_CoV_2_infection_in_children_ L2 - https://www.tandfonline.com/doi/full/10.1080/20469047.2021.1888026 DB - PRIME DP - Unbound Medicine ER -