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Eosinophilic folliculitis, eosinophilic dermatosis of hematologic malignancy and acneiform follicular mucinosis: Two case reports and a review of the literature highlighting the spectrum of histopathology.
J Cutan Pathol. 2021 Mar; 48(3):439-450.JC

Abstract

Within the literature, there is overlap in the histopathological features described in eosinophilic folliculitis associated with chronic lymphocytic leukemia (CLL), eosinophilic dermatosis of hematologic malignancy, and acneiform follicular mucinosis. These disorders are described with varying degrees of superficial and deep lymphocytic and eosinophilic inflammation demonstrating perivascular, perifollicular, and folliculocentric involvement with or without follicular mucin deposition. Given significant histopathological overlap, these diagnoses may represent a continuum on a spectrum of dermatoses. Here, we present two cases with histopathological elements that reflect components of this clinicopathological spectrum and compare our findings with previously reported cases to compare and contrast reported features. Our first case is a 71-year-old African American man with long-standing CLL who developed a pruritic erythematous papular eruption on the face and chest with biopsy revealing a dense folliculotropic lymphocytic infiltrate with conspicuous eosinophils and follicular mucinosis. Our second case is a 70-year-old Caucasian man recently diagnosed with CLL/small lymphocytic lymphoma who developed an erythematous papular rash on the neck and face with biopsy revealing superficial and deep perivascular and periadnexal lymphocytic inflammation with scattered eosinophils. Characterization of our two cases and comparison with available literature suggest that these disorders may represent a continuum of dermatoses.

Authors+Show Affiliations

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.Dermatology Associates of Macomb-Oakland, Novi, Michigan, USA.Dermatopathology Center, Washington University School of Medicine, St. Louis, Missouri, USA.Dermatopathology Center, Washington University School of Medicine, St. Louis, Missouri, USA.Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA. Dermatopathology Center, Washington University School of Medicine, St. Louis, Missouri, USA.Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA. Dermatopathology Center, Washington University School of Medicine, St. Louis, Missouri, USA.

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

33617128

Citation

Bailey, Cedric A R., et al. "Eosinophilic Folliculitis, Eosinophilic Dermatosis of Hematologic Malignancy and Acneiform Follicular Mucinosis: Two Case Reports and a Review of the Literature Highlighting the Spectrum of Histopathology." Journal of Cutaneous Pathology, vol. 48, no. 3, 2021, pp. 439-450.
Bailey CAR, Laurain DA, Sheinbein DM, et al. Eosinophilic folliculitis, eosinophilic dermatosis of hematologic malignancy and acneiform follicular mucinosis: Two case reports and a review of the literature highlighting the spectrum of histopathology. J Cutan Pathol. 2021;48(3):439-450.
Bailey, C. A. R., Laurain, D. A., Sheinbein, D. M., Jones, H. A., Compton, L. A., & Rosman, I. S. (2021). Eosinophilic folliculitis, eosinophilic dermatosis of hematologic malignancy and acneiform follicular mucinosis: Two case reports and a review of the literature highlighting the spectrum of histopathology. Journal of Cutaneous Pathology, 48(3), 439-450. https://doi.org/10.1111/cup.13932
Bailey CAR, et al. Eosinophilic Folliculitis, Eosinophilic Dermatosis of Hematologic Malignancy and Acneiform Follicular Mucinosis: Two Case Reports and a Review of the Literature Highlighting the Spectrum of Histopathology. J Cutan Pathol. 2021;48(3):439-450. PubMed PMID: 33617128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eosinophilic folliculitis, eosinophilic dermatosis of hematologic malignancy and acneiform follicular mucinosis: Two case reports and a review of the literature highlighting the spectrum of histopathology. AU - Bailey,Cedric A R, AU - Laurain,Douglas A, AU - Sheinbein,David M, AU - Jones,Heather A, AU - Compton,Leigh A, AU - Rosman,Ilana S, Y1 - 2020/12/18/ PY - 2020/09/09/received PY - 2020/11/23/revised PY - 2020/12/02/accepted PY - 2021/2/22/entrez PY - 2021/2/23/pubmed PY - 2021/9/28/medline KW - chronic lymphocytic leukemia KW - cutaneous T‐cell lymphoma KW - eosinophilic dermatosis of hematologic malignancy KW - eosinophilic folliculitis SP - 439 EP - 450 JF - Journal of cutaneous pathology JO - J Cutan Pathol VL - 48 IS - 3 N2 - Within the literature, there is overlap in the histopathological features described in eosinophilic folliculitis associated with chronic lymphocytic leukemia (CLL), eosinophilic dermatosis of hematologic malignancy, and acneiform follicular mucinosis. These disorders are described with varying degrees of superficial and deep lymphocytic and eosinophilic inflammation demonstrating perivascular, perifollicular, and folliculocentric involvement with or without follicular mucin deposition. Given significant histopathological overlap, these diagnoses may represent a continuum on a spectrum of dermatoses. Here, we present two cases with histopathological elements that reflect components of this clinicopathological spectrum and compare our findings with previously reported cases to compare and contrast reported features. Our first case is a 71-year-old African American man with long-standing CLL who developed a pruritic erythematous papular eruption on the face and chest with biopsy revealing a dense folliculotropic lymphocytic infiltrate with conspicuous eosinophils and follicular mucinosis. Our second case is a 70-year-old Caucasian man recently diagnosed with CLL/small lymphocytic lymphoma who developed an erythematous papular rash on the neck and face with biopsy revealing superficial and deep perivascular and periadnexal lymphocytic inflammation with scattered eosinophils. Characterization of our two cases and comparison with available literature suggest that these disorders may represent a continuum of dermatoses. SN - 1600-0560 UR - https://www.unboundmedicine.com/medline/citation/33617128/Eosinophilic_folliculitis_eosinophilic_dermatosis_of_hematologic_malignancy_and_acneiform_follicular_mucinosis:_Two_case_reports_and_a_review_of_the_literature_highlighting_the_spectrum_of_histopathology_ L2 - https://doi.org/10.1111/cup.13932 DB - PRIME DP - Unbound Medicine ER -