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SARS-CoV-2 vaccination induces neutralizing antibodies against pandemic and pre-emergent SARS-related coronaviruses in monkeys.
bioRxiv. 2021 Feb 17B

Abstract

Betacoronaviruses (betaCoVs) caused the severe acute respiratory syndrome (SARS) and Middle East Respiratory Syndrome (MERS) outbreaks, and now the SARS-CoV-2 pandemic. Vaccines that elicit protective immune responses against SARS-CoV-2 and betaCoVs circulating in animals have the potential to prevent future betaCoV pandemics. Here, we show that immunization of macaques with a multimeric SARS-CoV-2 receptor binding domain (RBD) nanoparticle adjuvanted with 3M-052-Alum elicited cross-neutralizing antibody responses against SARS-CoV-1, SARS-CoV-2, batCoVs and the UK B.1.1.7 SARS-CoV-2 mutant virus. Nanoparticle vaccination resulted in a SARS-CoV-2 reciprocal geometric mean neutralization titer of 47,216, and robust protection against SARS-CoV-2 in macaque upper and lower respiratory tracts. Importantly, nucleoside-modified mRNA encoding a stabilized transmembrane spike or monomeric RBD protein also induced SARS-CoV-1 and batCoV cross-neutralizing antibodies, albeit at lower titers. These results demonstrate current mRNA vaccines may provide some protection from future zoonotic betaCoV outbreaks, and provide a platform for further development of pan-betaCoV nanoparticle vaccines.

Authors

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Pub Type(s)

Preprint

Language

eng

PubMed ID

33619494

Citation

Saunders, Kevin O., et al. "SARS-CoV-2 Vaccination Induces Neutralizing Antibodies Against Pandemic and Pre-emergent SARS-related Coronaviruses in Monkeys." BioRxiv : the Preprint Server for Biology, 2021.
Saunders KO, Lee E, Parks R, et al. SARS-CoV-2 vaccination induces neutralizing antibodies against pandemic and pre-emergent SARS-related coronaviruses in monkeys. bioRxiv. 2021.
Saunders, K. O., Lee, E., Parks, R., Martinez, D. R., Li, D., Chen, H., Edwards, R. J., Gobeil, S., Barr, M., Mansouri, K., Alam, S. M., Sutherland, L. L., Cai, F., Sanzone, A. M., Berry, M., Manne, K., Kapingidza, A. B., Azoitei, M., Tse, L. V., ... Haynes, B. F. (2021). SARS-CoV-2 vaccination induces neutralizing antibodies against pandemic and pre-emergent SARS-related coronaviruses in monkeys. BioRxiv : the Preprint Server for Biology. https://doi.org/10.1101/2021.02.17.431492
Saunders KO, et al. SARS-CoV-2 Vaccination Induces Neutralizing Antibodies Against Pandemic and Pre-emergent SARS-related Coronaviruses in Monkeys. bioRxiv. 2021 Feb 17; PubMed PMID: 33619494.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SARS-CoV-2 vaccination induces neutralizing antibodies against pandemic and pre-emergent SARS-related coronaviruses in monkeys. AU - Saunders,Kevin O, AU - Lee,Esther, AU - Parks,Robert, AU - Martinez,David R, AU - Li,Dapeng, AU - Chen,Haiyan, AU - Edwards,Robert J, AU - Gobeil,Sophie, AU - Barr,Maggie, AU - Mansouri,Katayoun, AU - Alam,S Munir, AU - Sutherland,Laura L, AU - Cai,Fangping, AU - Sanzone,Aja M, AU - Berry,Madison, AU - Manne,Kartik, AU - Kapingidza,Anyway B, AU - Azoitei,Mihai, AU - Tse,Longping V, AU - Scobey,Trevor D, AU - Spreng,Rachel L, AU - Rountree,R Wes, AU - DeMarco,C Todd, AU - Denny,Thomas N, AU - Woods,Christopher W, AU - Petzold,Elizabeth W, AU - Oguin,Thomas H, AU - Sempowski,Gregory D, AU - Gagne,Matthew, AU - Douek,Daniel C, AU - Tomai,Mark A, AU - Fox,Christopher B, AU - Seder,Robert, AU - Wiehe,Kevin, AU - Weissman,Drew, AU - Pardi,Norbert, AU - Acharya,Priyamvada, AU - Andersen,Hanne, AU - Lewis,Mark G, AU - Moore,Ian N, AU - Montefiori,David C, AU - Baric,Ralph S, AU - Haynes,Barton F, Y1 - 2021/02/17/ PY - 2021/2/23/entrez PY - 2021/2/24/pubmed PY - 2021/2/24/medline JF - bioRxiv : the preprint server for biology JO - bioRxiv N2 - Betacoronaviruses (betaCoVs) caused the severe acute respiratory syndrome (SARS) and Middle East Respiratory Syndrome (MERS) outbreaks, and now the SARS-CoV-2 pandemic. Vaccines that elicit protective immune responses against SARS-CoV-2 and betaCoVs circulating in animals have the potential to prevent future betaCoV pandemics. Here, we show that immunization of macaques with a multimeric SARS-CoV-2 receptor binding domain (RBD) nanoparticle adjuvanted with 3M-052-Alum elicited cross-neutralizing antibody responses against SARS-CoV-1, SARS-CoV-2, batCoVs and the UK B.1.1.7 SARS-CoV-2 mutant virus. Nanoparticle vaccination resulted in a SARS-CoV-2 reciprocal geometric mean neutralization titer of 47,216, and robust protection against SARS-CoV-2 in macaque upper and lower respiratory tracts. Importantly, nucleoside-modified mRNA encoding a stabilized transmembrane spike or monomeric RBD protein also induced SARS-CoV-1 and batCoV cross-neutralizing antibodies, albeit at lower titers. These results demonstrate current mRNA vaccines may provide some protection from future zoonotic betaCoV outbreaks, and provide a platform for further development of pan-betaCoV nanoparticle vaccines. UR - https://www.unboundmedicine.com/medline/citation/33619494/SARS_CoV_2_vaccination_induces_neutralizing_antibodies_against_pandemic_and_pre_emergent_SARS_related_coronaviruses_in_monkeys_ L2 - https://doi.org/10.1101/2021.02.17.431492 DB - PRIME DP - Unbound Medicine ER -
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